Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

Online
ISSN
2191-0251
See all formats and pricing
More options …
Volume 25, Issue 3-4

Issues

Stroke in a child with Adams-Oliver syndrome and mixed diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome

Benjamin U. Nwosu
  • Division of Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Seema Adhami
  • Division of Neurology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alan D. Rogol
  • Division of Endocrinology, Department of Pediatrics, Indiana University School of Medicine, IN, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-02-27 | DOI: https://doi.org/10.1515/jpem-2011-0465

Abstract

Diabetes mellitus complicated by mixed diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome presents a special challenge to physicians. There is no standard protocol for the management of mixed hyperglycemic hyperosmolar syndrome and diabetic ketoacidosis in children. The commonest cause of neurological deterioration during an episode of diabetic ketoacidosis is cerebral edema, whereas hyperosmolality often leads to thrombosis. The risks for these complications are further increased in diseases associated with vasculopathies. We present the first case of complex cerebral arteriovenous thrombosis leading to stroke in a child with Adams-Oliver syndrome, a genetic condition that is associated with abnormal vasculogenesis. He presented with new-onset double diabetes complicated by a combination of diabetic ketoacidosis and hyperglycemic hyperosmolar syndrome. Magnetic resonance imaging, magnetic resonance angiography, and magnetic resonance venography provided evidence for an ischemic stroke. Children and adolescents who present with a combination of hyperglycemic hyperosmolar syndrome and diabetic ketoacidosis should be monitored for neurologic deficits and must be investigated for both stroke and cerebral edema in the event of neurological deterioration.

Keywords: Adams-Oliver syndrome; diabetic ketoacidosis; double diabetes; hyperglycemic hyperosmolar syndrome

About the article

Corresponding author: Benjamin U. Nwosu, MD, Division of Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA Phone: +1-508-334-7872, Fax: +1-508-856-4287


Received: 2011-12-01

Accepted: 2012-01-04

Published Online: 2012-02-27

Published in Print: 2012-04-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 25, Issue 3-4, Pages 357–361, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2011-0465.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Alaysia Barrot, Thierry AGM Huisman, and Andrea Poretti
The Neuroradiology Journal, 2016, Volume 29, Number 5, Page 317

Comments (0)

Please log in or register to comment.
Log in