Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2016: 1.233

CiteScore 2016: 1.09

SCImago Journal Rank (SJR) 2016: 0.527
Source Normalized Impact per Paper (SNIP) 2016: 0.602

Online
ISSN
2191-0251
See all formats and pricing
More options …
Volume 25, Issue 7-8 (Aug 2012)

Issues

Adiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for Diabetes in Youth Study

Amy S. Shah
  • Corresponding author
  • Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Lawrence M. Dolan
  • Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Abigail Lauer
  • Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Cralen Davis
  • Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dana Dabelea
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stephen R. Daniels / Richard F. Hamman
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Santica Marcovina / R. Paul Wadwa / Elaine M. Urbina
  • Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-07-15 | DOI: https://doi.org/10.1515/jpem-2012-0070

Abstract

Persons with type 1 diabetes are at increased risk of developing vascular disease. Adiponectin concentrations may play an intermediate role in this process. We sought to determine whether adiponectin is correlated with vascular stiffness in adolescents with type 1 diabetes. Plasma adiponectin, pulse wave velocity (PWV), augmentation index (AIx-75), and brachial distensibility (BrachD) were collected in 225 adolescents. Outcomes were evaluated by sex, and regression models were used to determine whether adiponectin was an independent determinant of arterial stiffness. Males had lower adiponectin levels and stiffer vessels (lower BrachD, p<0.01) than females. Unadjusted correlations revealed that adiponectin was correlated with BrachD (p<0.01) but not PWV and AIx-75. After adjustment, adiponectin was not a significant predictor of BrachD. The most consistent predictors of increased stiffness were age, male sex, blood pressure, obesity, and total cholesterol (p<0.05). Adiponectin’s contributions to arterial stiffness appear to be masked by other cardiovascular risk factors in persons with type 1 diabetes.

Keywords: adiponectin; arterial stiffness; diabetes; pediatrics

About the article

Corresponding author: Amy S. Shah, MD MS, Division of Endocrinology, ML 7012, Cincinnati Children’s Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229, USA Phone: +1-513-636-4744, Fax: +1-513-636-7486


Received: 2012-03-09

Accepted: 2012-05-27

Published Online: 2012-07-15

Published in Print: 2012-08-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0070.

Export Citation

©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Jun Liang, Qinqin Qiu, Ying Gong, Xuekui Liu, Lianjun Dou, Caiyan Zou, Yu Wang, and Lu Qi
The Journal of Clinical Hypertension, 2015, Volume 17, Number 5, Page 395
[2]
Jens Jordan, Peter M. Nilsson, Vasilios Kotsis, Michael H. Olsen, Guido Grassi, Volkan Yumuk, Hans Hauner, Barbara Zahorska-Markiewicz, Hermann Toplak, Stefan Engeli, and Nick Finer
Journal of Hypertension, 2015, Volume 33, Number 3, Page 425
[3]
MJ Redondo, LM Rodriguez, MW Haymond, CS Hampe, EO Smith, A Balasubramanyam, and S Devaraj
Pediatric Diabetes, 2014, Volume 15, Number 8, Page 543

Comments (0)

Please log in or register to comment.
Log in