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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

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Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures

Ya-Ying Cheng
  • Internal Medicine Teaching and Research Room, Hebei Medical University, Shijiazhuang, Hebei, China
/ Xiu-Mian Zhao
  • Department of Pediatrics, Hebei General Hospital, Shijiazhuang, Hebei, China
/ Bao-Ping Cai
  • Department of Pediatrics, Hebei General Hospital, Shijiazhuang, Hebei, China
/ Li-Na Ma
  • Department of Pediatrics, Hebei General Hospital, Shijiazhuang, Hebei, China
/ Jian-Ying Yin
  • Department of Pediatrics, Hebei General Hospital, Shijiazhuang, Hebei, China
/ Guang-Yao Song
  • Corresponding author
  • Internal Medicine Teaching and Research Room, Hebei Medical University, Shijiazhuang, Hebei, China
  • Department of Endocrinology, Hebei General Hospital, Heping Road 348, Shijiazhuang, Hebei, 050051, China
  • Email:
Published Online: 2012-07-19 | DOI: https://doi.org/10.1515/jpem-2012-0095

Abstract

Objective: To explore the relationship between nesfatin-1 and growth and development in newborns.

Methods: Blood samples for nesfatin-1, ghrelin, insulin-like growth factor-1 (IGF-1), insulin and glucose were obtained from preterm (n=53) and term infants (n=60), including appropriate for gestational age (AGA) (n=32) and small for gestational age (SGA) infants (n=28). The relationship between nesfatin-1 and other metabolic hormones or anthropometric parameters was evaluated.

Results: The concentrations of nesfatin-1, ghrelin and insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) were higher in SGA than AGA infants (p=0.0358, 0.0163, 0.0001 and 0.0051, respectively), but IGF-1 levels and homeostasis model assessment-insulin sensitivity index (HOMA-ISI) were lower (p=0.033 and 0.0001, respectively). Nesfatin-1 levels in SGA infants were higher on postnatal day 0 (PND0) than in AGA infants (p=0.0358) and lower on PND7 (p=0.0002) and PND28 (p=0.0488). A negative correlation showed between nesfatin-1 and oral calorie intake (r=–0.446; p=0.017) and HOMA-ISI (r=–0.398; p=0.036), and a positive correlation between nesfatin-1 and HOMA-IR (r=0.43; p=0.023) in SGA infants.

Conclusion: Nesfatin-1 is involved in the physiological regulation of intrauterine and postnatal growth and development in SGA infants.

Keywords: energy homeostasis; growth and development; nesfatin-1; newborn

About the article

Corresponding author: Dr. Guang-Yao Song, Internal Medicine Teaching and Research Room, Hebei Medical University, Shijiazhuang, Hebei, 050017, China; and Department of Endocrinology, Hebei General Hospital, Heping Road 348, Shijiazhuang, Hebei, 050051, China, Phone: +311-85988556


Received: 2012-03-27

Accepted: 2012-06-03

Published Online: 2012-07-19

Published in Print: 2012-08-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0095. Export Citation

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