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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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Nesfatin-1 in newborns: relationship with endocrine and metabolic and anthropometric measures

Ya-Ying Cheng1 / Xiu-Mian Zhao2 / Bao-Ping Cai2 / Li-Na Ma2 / Jian-Ying Yin2 / 1, 3

1Internal Medicine Teaching and Research Room, Hebei Medical University, Shijiazhuang, Hebei, China

2Department of Pediatrics, Hebei General Hospital, Shijiazhuang, Hebei, China

3Department of Endocrinology, Hebei General Hospital, Heping Road 348, Shijiazhuang, Hebei, 050051, China

Corresponding author: Dr. Guang-Yao Song, Internal Medicine Teaching and Research Room, Hebei Medical University, Shijiazhuang, Hebei, 050017, China; and Department of Endocrinology, Hebei General Hospital, Heping Road 348, Shijiazhuang, Hebei, 050051, China, Phone: +311-85988556

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 7-8, Pages 727–732, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0095, July 2012

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Objective: To explore the relationship between nesfatin-1 and growth and development in newborns.

Methods: Blood samples for nesfatin-1, ghrelin, insulin-like growth factor-1 (IGF-1), insulin and glucose were obtained from preterm (n=53) and term infants (n=60), including appropriate for gestational age (AGA) (n=32) and small for gestational age (SGA) infants (n=28). The relationship between nesfatin-1 and other metabolic hormones or anthropometric parameters was evaluated.

Results: The concentrations of nesfatin-1, ghrelin and insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) were higher in SGA than AGA infants (p=0.0358, 0.0163, 0.0001 and 0.0051, respectively), but IGF-1 levels and homeostasis model assessment-insulin sensitivity index (HOMA-ISI) were lower (p=0.033 and 0.0001, respectively). Nesfatin-1 levels in SGA infants were higher on postnatal day 0 (PND0) than in AGA infants (p=0.0358) and lower on PND7 (p=0.0002) and PND28 (p=0.0488). A negative correlation showed between nesfatin-1 and oral calorie intake (r=–0.446; p=0.017) and HOMA-ISI (r=–0.398; p=0.036), and a positive correlation between nesfatin-1 and HOMA-IR (r=0.43; p=0.023) in SGA infants.

Conclusion: Nesfatin-1 is involved in the physiological regulation of intrauterine and postnatal growth and development in SGA infants.

Keywords: energy homeostasis; growth and development; nesfatin-1; newborn

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