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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

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Elevated α-fetoprotein levels in Van Wyk-Grumbach syndrome: a case report and review of literature

Nivedita Patni
  • Department of Pediatric Endocrinology, Miami Children’s Hospital, 3100 SW, 62nd Avenue, Miami, FL 33155, USA
  • :
/ Luisa F. Cervantes
  • Department of Pediatric Radiology, Miami Children’s Hospital, Miami, FL, USA
/ Alejandro Diaz
  • Department of Pediatric Endocrinology, Miami Children’s Hospital, 3100 SW, 62nd Avenue, Miami, FL 33155, USA
  • :
Published Online: 2012-07-11 | DOI: https://doi.org/10.1515/jpem-2012-0112

Abstract

The association between primary hypothyroidism and precocious puberty secondary to ovarian hyperstimulation has been recognized for over a century. Here, we report the case of a 9-year-old girl with severe primary hypothyroidism, who presented with premature menarche, enlarged pituitary gland, enlarged ovaries with multiple cysts, and elevated prolactin and α-feto protein levels. Pituitary and ovarian radiology findings, and α-feto protein levels normalized a few weeks after hypothyroidism treatment was started. Reviewing the literature we found several reports of increased levels of tumor markers in girls with this association. Thyroid function tests should be always part of the evaluation of patients with precocious puberty especially if the bone age is delayed. Tumor markers and liver function tests may be abnormal in patients with severe hypothyroidism and improve soon after thyroid hormone replacement is started.

Keywords: α-feto protein; hypothyroidism; precocious puberty; ovarian hyperstimulation

Corresponding authors: Nivedita Patni and Alejandro Diaz, Department of Pediatric Endocrinology, Miami Children’s Hospital, 3100 SW, 62nd Avenue, Miami, FL 33155, USA


Received: 2012-04-07

Accepted: 2012-06-09

Published Online: 2012-07-11

Published in Print: 2012-08-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 7-8, Pages 761–767, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0112, July 2012

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