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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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IMPACT FACTOR 2015: 0.912

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2191-0251
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18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism

Jigang Yang
  • Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
/ Leilei Yuan
  • Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
/ Jacqui K. Meeks
  • Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA
/ Nan Zhang
  • Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
/ Chunlin Li
  • Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
/ Ruirui Hao
  • Corresponding author
  • Medical Healthcare Center, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
  • Email:
Published Online: 2012-07-13 | DOI: https://doi.org/10.1515/jpem-2012-0114

Abstract

Congenital hyperinsulinism (CHI) during infancy is characterized by inappropriate insulin secretion resulting in persistent hypoglycemia. This can lead to irreversible severe neurological damage in the infant. There are two main histologic subtypes: diffuse and focal, both of which may require different surgical strategies. It is very important to differentiate focal leisons from diffuse leisons. However, the differentiation of diffuse leisons from focal leisons is challenging. Affected pancreatic areas utilize dihydroxyphenylalanine (DOPA) at a higher rate than normal pancreatic tissues; thus, labeling of L-DOPA with fluorine-18 (18F-DOPA) allows functional mapping of hyperinsulinism using positron emission tomography/computed tomography (PET/CT). In this article, we reviewed the 18F-DOPA PET/CT application in CHI. The aim of this review is to enhance the recognition of 18F-DOPA PET/CT application in the diagnosis of CHI.

Keywords: congenital hyperinsulinism; PET/CT; 18F-DOPA

About the article

Corresponding author: Ruirui Hao, Medical Healthcare Center, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China Phone: +86-10-13121275863, Fax: +86-10-63137595


Received: 2012-04-09

Accepted: 2012-05-27

Published Online: 2012-07-13

Published in Print: 2012-08-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0114. Export Citation

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