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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2016: 1.233

CiteScore 2016: 1.09

SCImago Journal Rank (SJR) 2016: 0.527
Source Normalized Impact per Paper (SNIP) 2016: 0.602

Online
ISSN
2191-0251
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Volume 25, Issue 7-8 (Aug 2012)

Issues

18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism

Jigang Yang
  • Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
  • Other articles by this author:
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/ Leilei Yuan
  • Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
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  • De Gruyter OnlineGoogle Scholar
/ Jacqui K. Meeks / Nan Zhang
  • Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
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  • De Gruyter OnlineGoogle Scholar
/ Chunlin Li
  • Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
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  • De Gruyter OnlineGoogle Scholar
/ Ruirui Hao
  • Corresponding author
  • Medical Healthcare Center, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-07-13 | DOI: https://doi.org/10.1515/jpem-2012-0114

Abstract

Congenital hyperinsulinism (CHI) during infancy is characterized by inappropriate insulin secretion resulting in persistent hypoglycemia. This can lead to irreversible severe neurological damage in the infant. There are two main histologic subtypes: diffuse and focal, both of which may require different surgical strategies. It is very important to differentiate focal leisons from diffuse leisons. However, the differentiation of diffuse leisons from focal leisons is challenging. Affected pancreatic areas utilize dihydroxyphenylalanine (DOPA) at a higher rate than normal pancreatic tissues; thus, labeling of L-DOPA with fluorine-18 (18F-DOPA) allows functional mapping of hyperinsulinism using positron emission tomography/computed tomography (PET/CT). In this article, we reviewed the 18F-DOPA PET/CT application in CHI. The aim of this review is to enhance the recognition of 18F-DOPA PET/CT application in the diagnosis of CHI.

Keywords: congenital hyperinsulinism; PET/CT; 18F-DOPA

About the article

Corresponding author: Ruirui Hao, Medical Healthcare Center, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China Phone: +86-10-13121275863, Fax: +86-10-63137595


Received: 2012-04-09

Accepted: 2012-05-27

Published Online: 2012-07-13

Published in Print: 2012-08-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0114.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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