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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Fatma Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board: Battelino, Tadej / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Deladoey, Johnny / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Lee, Warren / Mohn, Angelika / Zacharin, Margaret

12 Issues per year


IMPACT FACTOR 2016: 1.233

CiteScore 2016: 1.09

SCImago Journal Rank (SJR) 2016: 0.527
Source Normalized Impact per Paper (SNIP) 2016: 0.602

Online
ISSN
2191-0251
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Volume 25, Issue 9-10

Issues

Hypodipsic hypernatremia leading to reversible renal failure following surgery for craniopharyngioma

Ah Reum Kwon
  • Institute of Endocrinology, Yonsei University College of Medicine, Severance Hospital – Pediatric Endocrinology, Seoul, Republic of Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jung-Min Ann
  • Institute of Endocrinology, Yonsei University College of Medicine, Severance Hospital – Pediatric Endocrinology, Seoul, Republic of Korea
  • Other articles by this author:
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/ Jae Il Shin / Hyun Wook Chae
  • Institute of Endocrinology, Yonsei University College of Medicine, Severance Hospital – Pediatric Endocrinology, Seoul, Republic of Korea
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ho-Seong Kim
  • Corresponding author
  • Institute of Endocrinology, Yonsei University College of Medicine, Severance Hospital – Pediatric Endocrinology, Seoul, Republic of Korea
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-08-11 | DOI: https://doi.org/10.1515/jpem-2012-0176

Abstract

Thirst is stimulated by increases in effective plasma osmolality that are detected by cerebral osmoreceptors located in the vascular organ of the lamina terminalis. However, surgical destruction or organic lesions of the lamina terminalis decrease the sensation of thirst in response to increased plasma osmolality. A 17-year-old boy who was diagnosed with craniopharyngioma at the age of 10 years and underwent tumor resection and gamma knife surgery was admitted for non-symptomatic severe hypernatremia. Although the sodium level was 173 mmol/L and serum osmolality was also high (371 mOsm/kg), the patient did not report increased thirst. Laboratory analysis revealed hypertonic dehydration and acute non-oliguric renal failure due to dehydration. Treatment was based on correction of hypernatremia with hydration and education about regular, periodic water ingestion. The patient’s hypernatremia and acute non-oliguric renal failure resolved with controlled daily fluid intake. To our knowledge, this is the first report of decreased thirst sensation secondary to craniopharyngioma and tumor resection leading to severe hypernatremia and non-oliguric renal failure in an adolescent.

Keywords: craniopharyngioma; hypernatremia; hypodipsia; renal failure

About the article

Corresponding author: Ho-Seong Kim, Institute of Endocrinology, Yonsei University College of Medicine, Severance Hospital – Pediatric Endocrinology, Seoul, Republic of Korea


Received: 2012-06-08

Accepted: 2012-07-11

Published Online: 2012-08-11

Published in Print: 2012-10-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 25, Issue 9-10, Pages 1027–1030, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0176.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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