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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

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Volume 25, Issue 9-10 (Oct 2012)


Relationship between left ventricular mass and carotid intima media thickness in obese adolescents with non-alcoholic fatty liver disease

Ahmet Sert / Ozgur Pirgon
  • Faculty of Medicine, Department of Pediatric Endocrinology, S. Demirel University, Isparta, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ebru Aypar / Hakan Yilmaz / Dursun Odabas
Published Online: 2012-09-06 | DOI: https://doi.org/10.1515/jpem-2012-0187


Background/aims: No data are available examining the relationship between carotid intima media thickness (IMT) and left ventricular mass (LVM) in obese adolescents with non-alcoholic fatty liver disease (NAFLD). Therefore, we investigated LVM and carotid IMT in obese adolescents with NAFLD.

Methods: Eighty obese adolescents and 37 lean subjects were enrolled in the study. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver with high transaminases (NAFLD group and non-NAFLD group). Fasting blood samples were assayed for serum transaminases, glucose and insulin levels. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR).

Results: LVM measurements were higher in both NAFLD and non-NAFLD obese patients in comparison with the lean children. The NAFLD group had significantly higher LVM measurements than the non-NAFLD and lean groups. Carotid IMT was higher in both the NAFLD and non-NAFLD obese patients in comparison with the lean group. The NAFLD group had significantly higher carotid IMT measurements than the non-NAFLD and lean groups. LVM was positively correlated with HOMA-IR and serum alanine aminotransferase levels in the NAFLD obese group. Carotid IMT was positively correlated with HOMA-IR, serum alanine aminotransferase levels and LVM in the NAFLD obese group.

Conclusions: We demonstrated that obese adolescents with NAFLD have increased LVM and carotid IMT and low insulin sensitivity. Obese adolescents with NAFLD and increased carotid IMT may demonstrate a more adverse cardiovascular risk profile and higher LVM. Therefore, assessment of carotid IMT, in addition to echocardiography, may assist in risk stratification in obese adolescents with NAFLD with elevated cardiovascular risk factor levels.

Keywords: adolescent; carotid intima media thickness; insulin resistance; left ventricular mass; non-alcoholic fatty liver disease

About the article

Corresponding author: Ahmet Sert, Department of Pediatric Cardiology, Konya Training and Research Hospital, 42080, Konya, Turkey, Phone: +90 332 323 67 09, Fax: +90 332 323 67 23

Received: 2012-06-13

Accepted: 2012-08-12

Published Online: 2012-09-06

Published in Print: 2012-10-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0187.

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©2012 by Walter de Gruyter Berlin Boston. Copyright Clearance Center

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