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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

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2191-0251
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Volume 26, Issue 1-2 (Feb 2013)

Issues

Pentoxifylline treatment for protecting diabetic retinopaty in children with type 1 diabetes

Murat Baykara
  • Department of Radiology, School of Medicine, Erciyes University, Kayseri, Turkey
/ Mehmet Emre Atabek
  • Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, School of Medicine, Necmettin Erbakan University, Konya, Turkey
/ Beray Selver Eklioglu
  • Corresponding author
  • Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, School of Medicine, Necmettin Erbakan University, Konya, Turkey
  • Email:
/ Selim Kurtoglu
  • Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, School of Medicine, Erciyes University, Kayseri, Turkey
Published Online: 2012-11-09 | DOI: https://doi.org/10.1515/jpem-2012-0166

Abstract

Objective: The purpose of this study was to determine whether oral pentoxifylline (PTX) would improve retinal microvascular hemodynamics in children with type 1 diabetes mellitus (DM).

Patients and methods: Non-invasive ultrasonographic measurements were made in 56 type 1 diabetic patients. The diabetic patients were matched first in terms of age, diabetes duration, then one individual within each pair was randomized into a pentoxifylline group and a control group. Pentoxifylline was administered for 6 months. We investigated the change of peak systolic velocity (PSV), end diastolic velocity (EDV), pulsatility index (PI), and resistivity index (RI) of central retinal artery (CRA) at 6 months after pentoxifylline. We investigated the relationship between PI, RI and carotide cross-sectional compliance (C-CSC).

Results: In comparison to changes in CRA measurements between the two groups, the pentoxifylline treatment group had significantly lower PI values (p=0.01). The RI, PSV and EDV were lower in pentoxifylline group but not statistifically different. There was a positive correlation between CRA PSV and carotid Vmax (cm/s) (r=0.29, p=0.02) and also C-CSC (r=0.27, p=0.03). In addition, there was a positive correlation between PI and C-CSC (r=0.3, p=0.02). In the pentoxifylline group there was a significant reduction in systolic blood pressure, diastolic blood pressure, microalbuminuria and an increase in HDL level.

Conclusion: Our results suggest that pentoxifylline may have a protective action for diabetic retinopathy and might modulate risk factors for atherosclerosis in type 1 diabetes.

Keywords: central retinal artery; common carotid artery; pentoxifylline; type 1 diabetes

About the article

Corresponding author: Beray Selver Eklioglu, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, Necmettin Erbakan University, Konya 42080, Turkey, Phone: +90 332 223 6350, Fax: +90 332 223 6181


Received: 2012-05-22

Accepted: 2012-09-17

Published Online: 2012-11-09

Published in Print: 2013-02-01



Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0166. Export Citation

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