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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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IMPACT FACTOR 2016: 1.233

CiteScore 2016: 1.09

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2191-0251
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Volume 26, Issue 1-2 (Feb 2013)

Issues

Absence of diabetes mellitus type 2 in obese children and adolescents in the north of Spain

Aníbal Aguayo
  • Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • These authors contributed equally to this work.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Amaia Vela
  • Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • These authors contributed equally to this work.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Angeles Aniel-Quiroga
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • Service Biochemistry, Hormone Laboratory, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Elizabeth Blarduni / Concepción Fernández / Gema Grau / Javier Núñez / Pedro Martul
  • Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Luis Castaño
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • Research Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Itxaso Rica
  • Corresponding author
  • Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-12-06 | DOI: https://doi.org/10.1515/jpem-2012-0200

Abstract

Background: The worldwide epidemic of childhood obesity has been accompanied by an increase in the incidence of carbohydrate metabolism disorders.

Objective: To determine the prevalence of type 2 diabetes mellitus (T2DM) and other carbohydrate metabolism disorders in obese young people in the Basque Country (Spain).

Design: Prospective observational study.

Patients: We studied 136 obese Caucasian children and adolescents (body mass index ≥2 SDS above the mean).

Measurements: Their severity of obesity was classified as mild <3 SDS or moderate-to-severe ≥3 SDS. Data were collected on clinical and metabolic parameters; insulin resistance (IR) was calculated using the homeostasis model assessment, and an oral glucose tolerance test (OGTT) was carried out.

Results: T2DM was not found. Impaired glucose tolerance (IGT) was found in 9.6% of patients being higher in moderate-to-severe obesity (12.8% vs. 2.4%; p=0.048) and in patients with acanthosis nigricans (27.8% vs. 6.8%; p=0.016). No differences were detected by sex or pubertal development in metabolic results as a function of OGTT’s response. IR (13.5%) was higher among those with moderate-to-severe obesity, in patients with acanthosis nigricans and was associated with other cardiovascular disease risk factors.

Conclusions: We found no children with T2DM. The prevalence of IGT and IR was related to severity of obesity, to the association of acanthosis nigricans and was associated with cardiovascular risk.

Keywords: childhood; glucose intolerance; insulin resistance; obesity; type 2 diabetes mellitus

About the article

Corresponding author: Itxaso Rica, MD, PhD, Paediatric Endocrinology Unit, Hospital Universitario Cruces, Plaza de Cruces s/n, 48903, Barakaldo, Bizkaia, Spain


Received: 2012-06-21

Accepted: 2012-10-05

Published Online: 2012-12-06

Published in Print: 2013-02-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0200.

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