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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

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Absence of diabetes mellitus type 2 in obese children and adolescents in the north of Spain

Aníbal Aguayo
  • Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • These authors contributed equally to this work.
/ Amaia Vela
  • Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • These authors contributed equally to this work.
/ Angeles Aniel-Quiroga
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • Service Biochemistry, Hormone Laboratory, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
/ Elizabeth Blarduni
  • Paediatric Service, Zumarraga Hospital, Zumarraga, Spain
/ Concepción Fernández
  • Paediatric Endocrinology Unit, Basurto University Hospital, Bilbao, Spain
/ Gema Grau
  • Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
/ Javier Núñez
  • Paediatric Service, Mendaro Hospital, Mendaro, Spain
/ Pedro Martul
  • Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
/ Luis Castaño
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • Research Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
/ Itxaso Rica
  • Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
  • Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
  • :
Published Online: 2012-12-06 | DOI: https://doi.org/10.1515/jpem-2012-0200

Abstract

Background: The worldwide epidemic of childhood obesity has been accompanied by an increase in the incidence of carbohydrate metabolism disorders.

Objective: To determine the prevalence of type 2 diabetes mellitus (T2DM) and other carbohydrate metabolism disorders in obese young people in the Basque Country (Spain).

Design: Prospective observational study.

Patients: We studied 136 obese Caucasian children and adolescents (body mass index ≥2 SDS above the mean).

Measurements: Their severity of obesity was classified as mild <3 SDS or moderate-to-severe ≥3 SDS. Data were collected on clinical and metabolic parameters; insulin resistance (IR) was calculated using the homeostasis model assessment, and an oral glucose tolerance test (OGTT) was carried out.

Results: T2DM was not found. Impaired glucose tolerance (IGT) was found in 9.6% of patients being higher in moderate-to-severe obesity (12.8% vs. 2.4%; p=0.048) and in patients with acanthosis nigricans (27.8% vs. 6.8%; p=0.016). No differences were detected by sex or pubertal development in metabolic results as a function of OGTT’s response. IR (13.5%) was higher among those with moderate-to-severe obesity, in patients with acanthosis nigricans and was associated with other cardiovascular disease risk factors.

Conclusions: We found no children with T2DM. The prevalence of IGT and IR was related to severity of obesity, to the association of acanthosis nigricans and was associated with cardiovascular risk.

Keywords: childhood; glucose intolerance; insulin resistance; obesity; type 2 diabetes mellitus

Corresponding author: Itxaso Rica, MD, PhD, Paediatric Endocrinology Unit, Hospital Universitario Cruces, Plaza de Cruces s/n, 48903, Barakaldo, Bizkaia, Spain


Received: 2012-06-21

Accepted: 2012-10-05

Published Online: 2012-12-06

Published in Print: 2013-02-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 26, Issue 1-2, Pages 25–29, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0200, December 2012

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[1]
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[2]
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M. Mata-Cases, S. Artola, J. Escalada, P. Ezkurra-Loyola, J.C. Ferrer-García, J.A. Fornos, J. Girbés, and I. Rica
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[6]
M. Mata-Cases, S. Artola, J. Escalada, P. Ezkurra-Loyola, J.C. Ferrer-García, J.A. Fornos, J. Girbés, and I. Rica
Endocrinología y Nutrición, 2015, Volume 62, Number 3, Page e23
[7]
Andrea Iorio, Sara Piacentini, Renato Polimanti, Flavio De Angelis, Rosario Calderon, and Maria Fuciarelli
American Journal of Human Biology, 2014, Volume 26, Number 3, Page 361

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