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Licensed Unlicensed Requires Authentication Published by De Gruyter November 29, 2012

Severe hypothalamopituitary dysfunction accompanied by influenza-associated encephalopathy: report of two pediatric cases

  • Hideaki Yagasaki EMAIL logo , Kisho Kobayashi , Tomohiro Saito , Yusuke Goto and Takayuki Komai

Abstract

Severe influenza infection may lead to neurological damage, such as encephalopathy. This may, in turn, cause acquired hypothalamopituitary dysfunction, which can result in severe morbidity and even death. We herein report two pediatric patients who developed influenza-associated hypopituitarism and were subsequently diagnosed with encephalopathy. They were diagnosed with acute necrotizing encephalopathy and postresuscitation encephalopathy, respectively. Both showed evidence of endocrine dysfunction, and hormone replacement therapy of adrenal, thyroid, and antidiuretic hormones are resulting in continued cardiac activity and resulted in prolonged survival. Screening for endocrine function is important in patients with severe central nervous system dysfunction.


Corresponding author: Hideaki Yagasaki, Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan Phone: +81 55-273-9606, Fax: +81 55-273-6745

Received: 2012-9-26
Accepted: 2012-10-23
Published Online: 2012-11-29
Published in Print: 2013-02-01

©2013 by Walter de Gruyter Berlin Boston

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