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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

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2191-0251
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Volume 26, Issue 11-12

Issues

A levothyroxine dose recommendation for the treatment of children and adolescents with autoimmune thyroiditis induced hypothyroidism

Victoria Ellerbroek
  • Corresponding author
  • Department of Pediatric Endocrinology, Children’s Hospital, Technical University of Munich, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Katharina Warncke
  • Department of Pediatric Endocrinology, Children’s Hospital, Technical University of Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Julia Köhle
  • Department of Pediatric Endocrinology, Children’s Hospital, Technical University of Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Walter Bonfig
  • Corresponding author
  • Department of Pediatric Endocrinology, Children’s Hospital, Technical University of Munich, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-06-08 | DOI: https://doi.org/10.1515/jpem-2013-0038

Abstract

Objective: To determine a levothyroxine (T4) dose recommendation for the treatment of autoimmune thyroiditis (AIT)-induced hypothyroidism.

Methods: T4 doses in 75 children and adolescents with newly diagnosed AIT were prospectively collected and compared to T4 doses of patients with congenital hypothyroidism (CH, n=22).

Results: Sixty-four patients with AIT and 22 patients with CH were included in the analysis. The thyroid-stimulating hormone declined significantly from 25.8±50.1 to 2.1±1.5 μIU/mL (AIT group; p<0.01) and from 338.7±380.7 to 1.9±1.6 μIU/mL (CH group; p<0.01). The required T4 dose for patients with AIT was 1.5±0.5 μg/kg per day (≥6 to <10 years: 2.0±0.4 μg T4/kg per day; ≥10 to <12 years: 1.6±0.4 μg T4/kg per day; ≥12 to <14 years: 1.5±0.6 μg T4/kg per day; ≥14 years: 1.4±0.6 μg T4/kg per day). It deviated significantly from the CH patients’ mean T4 dose of 2.8±0.7 μg T4/kg per day, p<0.01. CH patients with athyreosis required an average dose of 3.1±0.5 μg T4/kg per day; patients with ectopia, 2.6±0.7 μg T4/kg per day; and patients with dyshormonogenesis, 2.5±0.6 μg T4/kg per day.

Conclusion: Juvenile patients with AIT require significantly lower T4 doses than patients with CH.

Keywords: autoimmune thyroid disease; Hashimoto’s thyroiditis; pediatric hypothyroidism; thyroxine

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About the article

Corresponding authors: Victoria Ellerbroek and Walter Bonfig, Department of Pediatrics, Children’s Hospital, Technical University of Munich, Parzivalstr. 16, 80804 München, Germany, Phone: +49 89 3068 2589, Fax: +49 89 3068 3849, E-mail: ;


Received: 2013-01-26

Accepted: 2013-05-14

Published Online: 2013-06-08

Published in Print: 2013-11-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 11-12, Pages 1023–1028, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2013-0038.

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