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Licensed Unlicensed Requires Authentication Published by De Gruyter May 30, 2013

Central precocious puberty in a girl with Prader-Willi syndrome

  • Hae Sang Lee and Jin Soon Hwang EMAIL logo

Abstract

Prader-Willi syndrome (PWS) is characterized by infantile lethargy and hypotonia causing poor feeding and failure to thrive, childhood obesity, short stature, and hypogonadism. The complex phenotype is most probably caused by a hypothalamic dysfunction that is responsible for the hormonal dysfunction. The resulting hypogonadism in PWS causes incomplete, delayed, and sometimes disordered pubertal development. Precocious puberty is very rare in PWS. We report the case of a girl with PWS who was diagnosed with idiopathic precocious puberty and was treated with gonadotropin-releasing hormone analog.


Corresponding author: Jin Soon Hwang, MD, PhD, Department of Pediatrics, Ajou University School of Medicine, San 5, Wonchon-dong, Yeongtong-gu, Suwon 443-721, Korea, Phone: +82 312195166, Fax: +82 312195169, E-mail:

Conflict of interest statement

Disclosure: None of the authors has any conflict of interest to disclose.

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Received: 2013-1-30
Accepted: 2013-4-30
Published Online: 2013-05-30
Published in Print: 2013-11-01

©2013 by Walter de Gruyter Berlin Boston

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