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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma

IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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Volume 26, Issue 3-4


Predicting growth response among Egyptian prepubertal idiopathic isolated growth hormone deficient children

Nermin Salah / Soha M. Abd El Dayem / Lobna Fawaz / Marwa Ibrahim
Published Online: 2013-01-22 | DOI: https://doi.org/10.1515/jpem-2012-0074


Objective: To determine the predictors of growth response to growth hormone treatment in a group of isolated idiopathic growth hormone (GH).

Patients and methods: 477 GH deficient (GHD) children with GH therapy were included in the study. Patients were followed up for a minimum of 1 year and up to 6 years. Multiple linear regressions were performed to identify predictors of growth response to rhGH in the first 4 years of treatment.

Results: In the first year, three significant predictors of growth were identified: GH peak [ln (ug/L)], age of onset of therapy and target height-height SDS. In the second and third years of therapy, growth velocity (GV) was both significantly and positively correlated to the GV (cm/year) of the previous year.

Conclusion: Prediction models offer a valuable tool for individualization and assuring adherence to rhGH and thus a cost effective treatment, which is the ultimate goal of GH therapy.

Keywords: growth hormone deficient (GHD) children; growth response; prediction

About the article

Corresponding author: Soha M. Abd El Dayem, Professor of Pediatrics, National Research Centre, Cairo, Egypt, Phone: +2 0106716852

Received: 2012-03-13

Accepted: 2012-06-29

Published Online: 2013-01-22

Published in Print: 2013-04-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 3-4, Pages 247–255, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0074.

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©2013 by Walter de Gruyter Berlin Boston.Get Permission

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