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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

Online
ISSN
2191-0251
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Volume 26, Issue 3-4

Issues

Egyptian growth hormone deficient patients: demographic, auxological characterization and response to growth hormone therapy

Nermin Salah / Soha M. Abd El Dayem / Fatma El Mogy / Maha Amin / Marwa Ibrahim
Published Online: 2013-01-22 | DOI: https://doi.org/10.1515/jpem-2012-0091

Abstract

Objective: To study growth response to growth hormone (GH) treatment in growth hormone-deficient (GHD) patients.

Patients and methods: In total, 477 GHD children were included in the study. Patients were followed up for a minimum of 1 year and up to 6 years, anthropometric assessment was performed every 3 months, while thyroid profile was followed every 6 months. Student’s t-test was used for analysis of two quantitative variables.

Results: Patients with complete GHD and multiple pituitary hormone deficiency were significantly shorter as expressed in their height standard deviation score (SDS), target height – height (SDS) and a more bone age delay. Patients with complete GHD showed better growth response compared with those with partial GHD in the first 2 years of therapy.

Conclusion: We conclude that anthropometric assessment is the cornerstone in GHD diagnosis and follow-up, where catch up growth occurs in the first 2 years of therapy followed by a plateau.

Keywords: growth hormone-deficient patients; response to growth hormone

About the article

Corresponding author: Soha M. Abd El Dayem, Professor of Pediatrics, Pediatrics Department, National Research Center, Cairo, Egypt, Phone: +2-0106716852


Received: 2012-03-25

Accepted: 2012-09-21

Published Online: 2013-01-22

Published in Print: 2013-04-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 3-4, Pages 257–269, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0091.

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©2013 by Walter de Gruyter Berlin Boston.Get Permission

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