Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2016: 1.233

CiteScore 2016: 1.09

SCImago Journal Rank (SJR) 2015: 0.493
Source Normalized Impact per Paper (SNIP) 2015: 0.600

Online
ISSN
2191-0251
See all formats and pricing
In This Section
Volume 26, Issue 3-4 (Apr 2013)

Issues

Children at risk of diabetes type 1. Treatment with acetyl-L-carnitine plus nicotinamide – Case reports

Ivana Cristina Fernandez
  • Diabetes Division, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina
/ María del Carmen Camberos
  • Endocrinology Research Center (CEDIE-CONICET), Endocrinology Division, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina
/ Gisel Anabel Passicot
  • Endocrinology Research Center (CEDIE-CONICET), Endocrinology Division, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina
/ Lucía Camila Martucci
  • Endocrinology Research Center (CEDIE-CONICET), Endocrinology Division, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina
/ Juan Carlos Cresto
  • Corresponding author
  • Endocrinology Research Center (CEDIE-CONICET), Htal. de Niños “R. Gutiérrez”, Gallo 1330 (1425), Buenos Aires, Argentina
  • Email:
Published Online: 2012-06-20 | DOI: https://doi.org/10.1515/jpem-2012-0128

Abstract

Objectives: The aim was to evaluate the treatment with acetyl-L-carnitine (50 mg/kg/day) and nicotinamide (25 mg/kg/day) in children at risk of type 1 diabetes. This treatment was effective and harmless in experimental type 1 diabetes in mice.

Patients: Nine out of seventy healthy participants of the type 1 diabetes risk study were treated. They were typified for diabetes with HLA-DQB1 and positive autoantibodies. Children with a first peak of insulin response ≤48 µU were randomly distributed in control and treated patients. Children evolution was followed with an intravenous glucose tolerance test. Control children were treated when was another risk parameter was added. During their evolution all children were treated.

Results: Treatment periods differ (range: 120–16 months) because children began treatment at different times. During the treatment 4 patients recovered their parameters and the medication was suspended; 2 patients continued the treatment with favorable evolution. Two children evolved slowly with normal growth and development. One girl became diabetic because she was treated late.

Conclusions: In children at risk, this treatment delays the development or remits the evolution of type 1 diabetes

Keywords: acetyl-L-carntine plus nicotinamide treatment; intravenous glucose tolerance test; longitudinal study; patients at risk of type 1 diabetes

About the article

Corresponding author: Juan Carlos Cresto, MD, PhD, Endocrinology Research Center (CEDIE-CONICET), Htal. de Niños “R. Gutiérrez”, Gallo 1330 (1425), Buenos Aires, Argentina Phone: 054-11-4963-5931 int. 123, Fax: 054-11-4963-5930


Received: 2012-04-19

Accepted: 2012-04-27

Published Online: 2012-06-20

Published in Print: 2013-04-01



Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0128. Export Citation

Comments (0)

Please log in or register to comment.
Log in