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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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2191-0251
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Volume 26, Issue 3-4

Issues

Age-related reference values for plasma amino acids in a Spanish population measured by gas chromatography-mass spectrometry

Jose Antonio Méndez
  • Corresponding author
  • Laboratorio de Investigación Microbiología, Complejo Hospitalario Universitario A Coruña, As Xubias 84, 15006 A Coruña, Spain
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Antonio L. Fernández-Sanmamed
  • Laboratorio de Análisis Clínicos, Complejo Hospitalario Universitario A Coruña, Coruña, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Maria S. Gómez-Holgado
  • Laboratorio de Análisis Clínicos, Complejo Hospitalario Universitario A Coruña, Coruña, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Fernando Fernández-Rodríguez
  • Laboratorio de Análisis Clínicos, Complejo Hospitalario Universitario A Coruña, Coruña, Spain
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-01-17 | DOI: https://doi.org/10.1515/jpem-2012-0168

Abstract

Objectives: Reference ranges of blood plasma amino acids are required for the diagnosis and management of inherited metabolic disorders affecting one or more amino acids and can significantly impact the clinical decision-making and the quality of patient care. Our objective was to establish the reference values for plasma amino acids in a Spanish population measured by gas chromatography-mass spectrometry (GC-MS).

Methods: Amino acids were extracted, derivatized to N(O)-tert-butyldimethylsilyl, and analyzed by GC-MS.

Results: Significant differences in the concentrations of several amino acids have been determined between age groups. Such differences might be due to a combination of several factors, including age, genetic factors, nutritional status, and dietary habits.

Conclusions: The amino acid values are not evidently affected by sex, but they do vary with age. Such data help to provide a basis for diagnosing metabolic abnormalities. To our knowledge, this is the first published article showing the age-related reference ranges for plasma amino acids analyzed by GC-MS.

Keywords: amino acids; gas chromatography; inherited metabolic disorders; mass spectrometry; reference values

About the article

Corresponding author: Jose Antonio Méndez, Laboratorio de Investigación Microbiología, Complejo Hospitalario Universitario A Coruña, As Xubias 84, 15006 A Coruña, Spain, Phone: +34-981-178000, Fax: +34-981-17-81-44


Received: 2012-05-26

Accepted: 2012-11-21

Published Online: 2013-01-17

Published in Print: 2013-04-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 3-4, Pages 333–341, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0168.

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