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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

Online
ISSN
2191-0251
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Volume 26, Issue 3-4

Issues

Protective mechanisms against oxidative stress and angiopathy in young patients with diabetes type 1 (DM1)

Nikolitsa Koutroumani
  • University of Patras School of Medicine-Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Patras, Achaia, Greece
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/ Ioanna Partsalaki
  • University of Patras School of Medicine-Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Patras, Achaia, Greece
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/ Fotini Lamari
  • University of Patras, Laboratory of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, Patras, Achaia, Greece
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/ Athina Dettoraki
  • University of Patras School of Medicine-Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Patras, Achaia, Greece
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/ Andrea Paola Rojas Gil
  • University of Patras School of Medicine-Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Patras, Achaia, Greece
  • University of Peloponnese, Faculty of Human Movement and Quality of Life Sciences, Department of Nursing, Orthias Artemidos and Plateon Sparta, Sparta, Lakonias, Greece
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/ Alexia Karvela
  • University of Patras School of Medicine-Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Patras, Achaia, Greece
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/ Eirini Kostopoulou
  • University of Patras School of Medicine-Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Patras, Achaia, Greece
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/ Bessie E. Spiliotis
  • Corresponding author
  • University of Patras School of Medicine-Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Patras, Achaia, Greece
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Published Online: 2013-01-22 | DOI: https://doi.org/10.1515/jpem-2012-0183

Abstract

Objective: Advanced glycation end-products (AGEs) via their receptor, RAGE, are involved in diabetic angiopathy. Soluble RAGE, an inhibitor of this axis, is formed by enzymatic catalysis (sRAGE) or alternative splicing (esRAGE). Malondialdehyde (MDA) is an oxidative stress marker, and ferric reducing ability of plasma (FRAP) is an anti-oxidant capacity marker.

Methods: In isolated mononuclear blood cells from 110 DM1-patients (P) and 124 controls (C) (4–29 years) RAGE mRNA (g) and protein expression (pe) were measured by RT-PCR and Western immunoblotting, respectively. Plasma levels of CML (AGEs) and sRAGE were measured by ELISA, MDA by flurometry and FRAP according to ‘Benzie and Strain’.

Results: P showed: (i) higher g of RAGE, especially in p>13 years of age and >5 years DM1, (ii) increased pe of esRAGE in DM1>5 years and (iii) increased FRAP and MDA.

Conclusions: The increased esRAGE and FRAP with increased levels of CML and MDA possibly reflects a protective response against the formation of diabetic complications in these young diabetic patients.

Keywords: advanced glycation end-products (AGEs); diabetes mellitus type 1; oxidative stress; RAGE; soluble RAGE

About the article

Corresponding author: Bessie E. Spiliotis, University of Patras School of Medicine, Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Patras, Achaia, Greece


Received: 2012-06-11

Accepted: 2012-08-04

Published Online: 2013-01-22

Published in Print: 2013-04-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 3-4, Pages 309–317, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0183.

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©2013 by Walter de Gruyter Berlin Boston.Get Permission

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