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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

Online
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2191-0251
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Volume 26, Issue 3-4

Issues

Mitochondrial uncoupling protein 2 (UCP2) gene polymorphisms are associated with childhood obesity and related metabolic disorders

Sibel Oguzkan-Balci
  • Corresponding author
  • Department of Medical Biology and Genetics, Faculty of Medicine,University of Gaziantep, Gaziantep, Turkey
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nilgun Col-Araz / Muradiye Nacak / Mustafa Araz
  • Department of Endocrinology and Metabolism, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
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  • De Gruyter OnlineGoogle Scholar
/ Halime Sabanci
  • Department of Medical Biology and Genetics, Faculty of Medicine,University of Gaziantep, Gaziantep, Turkey
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  • De Gruyter OnlineGoogle Scholar
/ Ayse Balat
  • Department of Pediatric Nephrology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
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  • De Gruyter OnlineGoogle Scholar
/ Sacide Pehlivan
  • Department of Medical Biology and Genetics, Faculty of Medicine,University of Gaziantep, Gaziantep, Turkey
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2012-12-20 | DOI: https://doi.org/10.1515/jpem-2012-0267

Abstract

Objective: This study aimed to investigate the possible role of uncoupling protein 2 (UCP2) gene polymorphisms in childhood obesity and related metabolic disorders.

Methods: Obese patients (n=100) and healthy controls (n=100) were analyzed for -866G>A and insertion/deletion (I/D) polymorphisms of the UCP2 gene by polymerase chain raction and/or restriction fragment length polymorphism.

Results: UCP2 I/D polymorphism showed an association with obesity. The insertion homozygous genotype (II) was higher in obese patients (p=0.0001), while the DD genotype was higher in controls (p=0.0034). Body mass index and relative weight were lower in patients carrying the A allele of the -866G>A polymorphism (p=0.021 and p=0.047, respectively). There was an association between insulin resistance and –866A allele carrier patients with consanguineous parents (p=0.005).

Conclusion: Insertion homozygous genotype and the allele of I/D polymorphism were found to be risk factors for childhood obesity and related metabolic disorders. The -866A allele was associated with susceptibility to central adiposity, hypercholesterolemia, hypertriglyceridemia and insulin resistance.

Keywords: childhood obesity; insulin resistance; mitochondria; polymorphism; uncoupling protein 2

About the article

Corresponding author: Associate Professor Sibel Oguzkan-Balci, Department of Medical Biology and Genetics, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey, Phone: +90 342 3606060, Fax: +90 342 3601617


Received: 2012-08-16

Accepted: 2012-11-12

Published Online: 2012-12-20

Published in Print: 2013-04-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 3-4, Pages 277–283, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0267.

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