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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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2191-0251
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Volume 26, Issue 3-4

Issues

Parathyroid hormone-independent hypercalcemia in an infant with renal dysplasia: possible role of PTHrP

Francisca Grob
  • Pediatric Endocrinology Unit, Division of Pediatrics, Pontificia Universidad Católica, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Pedro Zambrano
  • Pediatric Nephrology Unit, Division of Pediatrics, Pontificia Universidad Católica, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ximena Ibarra
  • Pediatric Nephrology Unit, Division of Pediatrics, Pontificia Universidad Católica, Santiago, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ María Loreto Reyes
  • Corresponding author
  • Pediatric Endocrinology Unit, Division of Pediatrics, Pontificia Universidad Católica, Santiago, Chile
  • Email
  • Other articles by this author:
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Published Online: 2013-01-17 | DOI: https://doi.org/10.1515/jpem-2012-0286

Abstract

Background: Parathyroid hormone (PTH)-independent hypercalcemia in patients with chronic kidney failure is a rare and poor understood entity.

Case report: We report the case of an infant with stage III chronic kidney failure secondary to multicystic dysplastic kidney disease, who presented at 3 months of life with severe hypercalcemia, suppressed PTH, and elevated PTH-related peptide. Malignancy was discarded, and the patient was treated twice with bisphosphonates with an initial partial response. During follow-up, the calcium levels descended. To date, he has maintained normal serum calcium level for 1 year after discharge.

Conclusions: The presence of PTH-related peptide may play a role in hypercalcemia associated to multicystic dysplastic kidney disease possibly by the overproduction of this peptide in the kidney.

Keywords: chronic kidney failure; hypercalcemia; multicystic dysplastic kidney; parathyroid hormone-related protein

About the article

Corresponding author: María Loreto Reyes, Pediatric Endocrinology Unit, Division of Pediatrics, Pontificia Universidad Católica, Lira 85 piso 5, Santiago, 8330074 Chile, Phone: +(56-2) 23543402, Fax: +(56-2) 26384307


Received: 2012-09-05

Accepted: 2012-12-12

Published Online: 2013-01-17

Published in Print: 2013-04-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 3-4, Pages 365–367, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0286.

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[1]
Farzana Perwad and Lisa Keung
Bone Reports, 2018
[2]
Nardeen Kodous, Guido Filler, Ajay Parkash Sharma, and Tamara Angela Van Hooren
Canadian Journal of Kidney Health and Disease, 2015, Volume 2, Page 52

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