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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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2191-0251
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Volume 26, Issue 3-4

Issues

Glucose metabolism in obese and lean adolescents with polycystic ovary syndrome

Preamrudee Poomthavorn
  • Corresponding author
  • Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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/ Weerapong Chaya
  • Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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/ Pat Mahachoklertwattana
  • Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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/ Matchuporn Sukprasert
  • Faculty of Medicine, Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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/ Sawaek Weerakiet
  • Faculty of Medicine, Department of Obstetrics and Gynecology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
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Published Online: 2013-01-12 | DOI: https://doi.org/10.1515/jpem-2012-0328

Abstract

Data on glucose metabolism in Asian adolescents with polycystic ovary syndrome (PCOS) are limited. Glucose metabolism assessment using an oral glucose tolerance test (OGTT) in obese and lean Thai adolescents with PCOS, and a comparison between the two groups were done. Thirty-one patients (19 obese, 12 lean) were enrolled. Their median (range) age was 14.9 (11.0–21.0) years. Eighteen patients had abnormal glucose metabolism (13 hyperinsulinemia, 4 impaired glucose tolerance, and 1 diabetes). Compared between obese [median (range) BMI Z-score, 1.6 (1.2–2.6)] and lean [median (range) BMI Z-score, 0.1 (–1.4 to 0.6)] patients, the frequencies of each abnormal OGTT category, areas under the curves of glucose and insulin levels, and insulinogenic index were not different; however, insulin resistance was greater in the obese group. In conclusion, a high proportion of our adolescents with PCOS had abnormal glucose metabolism. Therefore, OGTT should be performed in adolescents with PCOS for the early detection of abnormal glucose metabolism.

Keywords: glucose tolerance; insulin resistance; obesity; polycystic ovary syndrome

About the article

Corresponding author: Preamrudee Poomthavorn, MD, Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand, Phone: +662 201 1394, Fax: +662 201 1850


Received: 2012-10-14

Accepted: 2012-12-03

Published Online: 2013-01-12

Published in Print: 2013-04-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 3-4, Pages 319–324, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0328.

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