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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

Online
ISSN
2191-0251
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Volume 26, Issue 3-4

Issues

From fat cell biology to public health preventive strategies – pinpointing the critical period for obesity prevention

Michal Efrat
  • Faculty of Health Sciences, Department of Nutrition, Ariel University Center, Israel
  • Faculty of Life Science, Bar-Ilan University, Israel
  • These authors contributed equally to this work.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sigal Tepper
  • Faculty of Health Sciences, Ben-Gurion University, Israel
  • These authors contributed equally to this work.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ruth Z. Birk
Published Online: 2013-01-17 | DOI: https://doi.org/10.1515/jpem-2012-0379

Abstract

The prevalence of childhood and adolescence obesity is increasing to alarming proportions worldwide and poses a major public health problem by significantly elevating the risks of chronic diseases. There is strong evidence that childhood overweight and obesity are risk factors for severe obesity over the whole life course. In fact, longitudinal studies have found that most overweight/obese children would become overweight and obese adults. There is a lack of coupling in the scientific literature between adipose tissue development and biology to obesity prevention and treatment strategies. This is of utmost importance, especially regarding childhood and adolescence, as the major scientific paradigm in studies of adiposity is that the major number of adipocytes is set for life at this early age. This review discusses the current adipose cell biology paradigms to pinpoint the critical factors and periods in childhood overweight and obesity and, consecutively, to develop relevant prevention strategies.

Keywords: adipocyte; adolescents; children; hyperplastic obesity; hypertrophic obesity; obesity

About the article

Corresponding author: Ruth Z. Birk, PhD, RD, Faculty of Health Sciences, Department of Nutrition, Ariel University Center, Israel, Phone: +972-3-9076594, Fax: +972-3-9066615


Received: 2012-08-31

Accepted: 2012-12-10

Published Online: 2013-01-17

Published in Print: 2013-04-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 3-4, Pages 197–209, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0379.

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