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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

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In This Section
Volume 26, Issue 5-6 (May 2013)


Prevalence of multiple forms of autoimmunity in Egyptian patients with Turner syndrome: relation to karyotype

Rasha T. Hamza
  • Corresponding author
  • Faculty of Medicine, Department of Pediatrics, Ain Shams University, Cairo, Egypt
  • Email:
/ Nader A. Raof
  • Faculty of Medicine, Department of Pediatrics, Ain Shams University, Cairo, Egypt
/ Khaled O. Abdallah
  • Faculty of Medicine, Department of Clinical Pathology, Ain Shams University, Cairo, Egypt
Published Online: 2012-10-26 | DOI: https://doi.org/10.1515/jpem-2012-0265


Our study aimed to investigate: the prevalence of autoantibodies related to organ-specific disease; the prevalence of some autoimmune diseases (AID) in Egyptian Turner syndrome (TS) patients; and the association of autoimmunity with patients’ karyotypes. Eighty TS patients were subjected to history, auxological assessment and measurement of antithyroid peroxidase antibody (ATPOAb), antithyroglobulin antibody (ATGAb), anti-tissue transglutaminase IgA antibodies (ATTIgAAb), anti-glutamic acid decarboxylase-65 antibodies (GAD-65-Ab) and anti-adrenal cortex antibodies (AACAb). Of the 80 TS patients, 54 (67.5%) were seropositive for one or more autoantibodies. Thirty-five percent were positive for ATPOAb, 15% for ATGAb, 12.5% for ATTIgAAb, 3.75% for Anti-GAD-65Ab and 1.25% for AACAb. There was a non-significant association between the 45,X karyotype and overall prevalence of autoantibodies (p=0.20), while IsoXq was associated with increased prevalence of ATPOAb (p<0.01), ATGAb (p=0.01) and anti-GAD-65Ab (p=0.02). Thus, female TS patients face a high prevalence of autoimmunity and associated AID.

Keywords: antibodies; autoimmunity; Egyptian; karyotype; Turner syndrome


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About the article

Corresponding author: Rasha T. Hamza, MD, Assistant Professor of Pediatrics and Pediatric Endocrinology, Faculty of Medicine, Department of Pediatrics, Ain Shams University, 36 Hisham Labib street, off Makram Ebeid street, Nasr City, Cairo, 11371, Egypt, Phone: +202 22734727, Fax: +202 26904430

Received: 2012-08-13

Accepted: 2012-09-17

Published Online: 2012-10-26

Published in Print: 2013-05-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0265. Export Citation

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