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Journal of Pediatric Endocrinology and Metabolism

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Volume 26, Issue 7-8


Interaction of bone mineral density, adipokines and hormones in obese adolescents girls submitted in an interdisciplinary therapy

Raquel M.S. Campos / Marco Túlio de Mello / Lian Tock / Patrícia Leão da Silva / Flávia C. Corgosinho / June Carnier / Aline de Piano / Priscila L. Sanches / Deborah C.L. Masquio / Sergio Tufik / Ana R. Dâmaso
  • Corresponding author
  • Post Graduate Program of Nutrition, Universidade Federal de São Paulo, Brazil
  • Department of Biosciences, Universidade Federal de São Paulo. Av. D. Ana Costa, 95 – Vl. Mathias – Santos/SP – CEP: 11060-001, Brazil
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  • Other articles by this author:
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Published Online: 2013-04-22 | DOI: https://doi.org/10.1515/jpem-2012-0336


Obesity is a chronic inflammatory condition with numerous metabolic consequences to the organism, highlighting its influence on bone mass. Therefore, the aim of this study was to verify the role of visceral fat, leptin, adiponectin and ghrelin on bone mineral density in obese post-puberty adolescents girls, submitted to an interdisciplinary therapy. The study involved 20 post-puberty obese adolescent girls: 16±1.5 years of age, 98.9±15.8 kg (weight), 1.60±0.72 m (height) and 37.2±4.8 kg/m2 [body mass index (BMI)]. Anthropometric measurements, body composition, visceral fat, subcutaneous fat, bone mineral density and content were determined. Ghrelin, leptin and adiponectin were analyzed and the leptin/adiponectin ratio was calculated. Our findings showed a significant increase in adiponectin concentration and a reduction in body weight, BMI, total fat mass, visceral and subcutaneous fat. In addition, ghrelin (r2=–0.53; p=0.02) visceral fat (r2=–0.46, p=0.04) (r2 –0.66, p=0.001) and leptin/adiponectin ratio (r2 –0.56, p=0.01) were negative predictors for bone mineral density and content in obese adolescent girls, respectively. It provides a novel physiologically concept that may shed light on the etiology of osteoporosis and help to identify new therapeutic targets. However this should be confirmed in a large cohort study.

Keywords: adipokines; adolescents; bone mineral density; hormone; obesity


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About the article

Corresponding authors: Raquel M.S. Campos, Post-Graduation Program of Nutrition, Universidade Federal de São Paulo. Rua Francisco de Castro 93, SP 04020-050, Brazil; and Ana R. Dâmaso, Department of Biosciences, Universidade Federal de São Paulo. Av. D. Ana Costa, 95 – Vl. Mathias – Santos/SP – CEP: 11060-001, Brazil, Tel.: (+55) 13 3878-3700

Received: 2012-08-30

Accepted: 2013-02-25

Published Online: 2013-04-22

Published in Print: 2013-08-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 26, Issue 7-8, Pages 663–668, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0336.

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