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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

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Volume 26, Issue 7-8 (Aug 2013)

Issues

The influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes

Tessa L. Crume
  • Corresponding author
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Advised on analysis, and wrote the manuscript.
  • Email
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/ Jeanette S. Andrews
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Wake Forest School of Medicine, Winston-Salem, NC, USA
  • Conducted the analysis, and reviewed and edited the manuscript.
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/ Ralph B. D’Agostino Jr.
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Wake Forest School of Medicine, Winston-Salem, NC, USA
  • Advised on analysis, and reviewed and edited the manuscript.
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/ David J. Pettitt
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Sansum Diabetes Research Institute, Santa Barbara, CA, USA
  • Reviewed and edited the manuscript.
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/ Elizabeth J. Mayer-Davis
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • University of North Carolina at Chapel Hill, School of Public Health and School of Medicine, Chapel Hill, NC, USA
  • Reviewed and edited the manuscript.
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/ Jennifer R. Law
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • University of North Carolina at Chapel Hill, School of Public Health and School of Medicine, Chapel Hill, NC, USA
  • Reviewed and edited the manuscript.
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/ Lawrence Dolan
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Cincinnati Children’s Hospital and the University of Cincinnati, Cincinnati, OH, USA
  • Reviewed and edited the manuscript.
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/ Jean M. Lawrence
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA
  • Reviewed and edited the manuscript.
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/ Sharon Saydah
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Centers for Disease Control and Prevention, Division of Diabetes Translation, Hyattsville, MD, USA
  • Reviewed and edited the manuscript.
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/ Carla Greenbaum
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Benaroya Research Institute at Virginia Mason, Seattle, WA, USA
  • Reviewed and edited the manuscript.
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/ Beatriz L. Rodriguez
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Kaukini Medical Center, Honolulu, HI, USA
  • Reviewed and edited the manuscript.
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/ Dana Dabelea and the SEARCH for Diabetes in Youth Study Group
  • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA
  • Advised on analysis, contributed to the discussion, and reviewed and edited the manuscript.
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Published Online: 2013-05-04 | DOI: https://doi.org/10.1515/jpem-2012-0385

Abstract

We explored the influence of exposure to maternal diabetes in utero on β cell decline measured by fasting C-peptide (FCP) among 1079 youth <20 years with diabetes, including 941 with type 1 and 138 with type 2 diabetes. Youths exposed to maternal diabetes had FCP levels that were 17% lower among youth with type 2 diabetes [95% confidence interval (CI): –34%, +6%] and 15% higher among youth with type 1 diabetes (95%CI: –14%, +55%) than their unexposed counterparts, although differences were not statistically significant (p=0.13 and p=0.35, respectively). Exposure to maternal diabetes was not associated with FCP decline in youth with type 2 (p=0.16) or type 1 diabetes (p=0.90); nor was the effect of in utero exposure on FCP modified by diabetes type. Findings suggest that exposure to maternal diabetes in utero may not be an important determinant of short-term β-cell function decline in youth with type 1 or type 2 diabetes.

Keywords: β-cell function; childhood type 2 diabetes; diabetes during pregnancy; fasting C-peptide; fetal exposure to diabetes; fetal overnutrition; gestational diabetes; type 1 diabetes

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About the article

Corresponding author: Tessa L. Crume, PhD, MSPH, Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, 13001 East 17th Ave, Box B119, Aurora, CO 80045, USA, Phone: +1 303 724 4452, Fax: +1 303 724 4620


Received: 2012-12-03

Accepted: 2013-03-24

Published Online: 2013-05-04

Published in Print: 2013-08-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0385.

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