Jump to ContentJump to Main Navigation
Show Summary Details

Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2015: 0.912

SCImago Journal Rank (SJR) 2015: 0.493
Source Normalized Impact per Paper (SNIP) 2015: 0.600
Impact per Publication (IPP) 2015: 0.955

Online
ISSN
2191-0251
See all formats and pricing
Just Accepted

Issues

The relationship between adiposity and stature in prepubertal children with celiac disease

Benjamin Udoka Nwosu
  • Corresponding author
  • University of Massachusetts Medical School, 55 Lake Avenue, North, Worcester, MA 01655, USA
  • Email:
/ Rachel I. Snook
  • University of Massachusetts Medical School, 55 Lake Avenue, North, Worcester, MA 01655, USA
/ Louise Maranda
  • University of Massachusetts Medical School, 55 Lake Avenue, North, Worcester, MA 01655, USA
Published Online: 2013-05-24 | DOI: https://doi.org/10.1515/jpem-2012-0312

Abstract

Background and aim: The pathogenesis of short stature in celiac disease (CD) is unknown. Obese children are generally taller than their non-obese peers; however, the role of adiposity on stature in CD is unclear. Our aim was to determine the association between adiposity and stature in CD.

Subjects and methods: We compared the anthropometric characteristics of prepubertal children of ages 3–12 years, with biopsy-proven CD (n=40) and who were not on gluten-free diet, to same aged, prepubertal non-CD children (n=50). Body mass index (BMI) was calculated using the formula weight/height2. Sex-adjusted midparental target height (MPTH) standard deviation score (SDS) was calculated using National Children Health Statistics data for 18-year-old adults. Data were expressed as mean±standard deviation.

Results: CD subjects had significantly lower BMI SDS than controls (0.61±1.22 vs. 1.28±1.60, p=0.027) but were not significantly shorter than the controls (–0.05±1.21 vs. 0.21±1.71, p=0.41). When the patients were subdivided into the normal-weight and overweight/obese groups, the normal-weight CD patients were of similar height as the normal-weight controls (p=0.76) but were significantly shorter than both the overweight/obese controls (p<0.001) and overweight/obese CD children (p<0.001). Interestingly, the overweight/obese CD children were significantly taller than the normal-weight controls (p=0.003). The MPTH SDS did not differ between the groups.

Conclusions: Overweight/obese prepubertal children with CD were taller than both their normal-weight CD peers and the normal-weight controls, but were of similar height as the overweight/obese control subjects.

Keywords: celiac disease; obesity; stature

References

  • 1.

    Fasano A. Should we screen for coeliac disease? Yes. Br Med J 2009;339:b3592.

  • 2.

    Corazza GR, Di Sario A, Sacco G, Zoli G, Treggiari EA, et al. Subclinical coeliac disease: an anthropometric assessment. J Intern Med 1994;236:183–7. [Crossref] [PubMed]

  • 3.

    Valletta E, Fornaro M, Cipolli M, Conte S, Bissolo F, et al. Celiac disease and obesity: need for nutritional follow-up after diagnosis. Eur J Clin Nutr 2010;64:1371–2. [PubMed] [Crossref]

  • 4.

    Telega G, Bennet TR, Werlin S. Emerging new clinical patterns in the presentation of celiac disease. Arch Pediatr Adolesc Med 2008;162:164–8. [Crossref] [PubMed] [Web of Science]

  • 5.

    Venkatasubramani N, Szabo S, Werlin SL. Autoimmune hepatitis in a child with chronic hepatitis B virus infection. J Pediatr Gastroenterol Nutr 2009;49:639–41. [Crossref]

  • 6.

    Reilly NR, Aguilar K, Hassid BG, Cheng J, Defelice AR, et al. Celiac disease in normal-weight and overweight children: clinical features and growth outcomes following a gluten-free diet. J Pediatr Gastroenterol Nutr 2011;53:528–31. [PubMed]

  • 7.

    Venkatasubramani N, Telega G, Werlin SL. Obesity in pediatric celiac disease. J Pediatr Gastroenterol Nutr 2010;51:295–7. [PubMed]

  • 8.

    Verkasalo M, Kuitunen P, Leisti S, Perheentupa J. Growth failure from symptomless celiac disease: a study of 14 patients. Helv Paediatr Acta 1978;33:489–95.

  • 9.

    Bottaro G, Cataldo F, Rotolo N, Spina M, Corazza GR. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am J Gastroenterol 1999;94:691–6. [PubMed]

  • 10.

    Meazza C, Pagani S, Laarej K, Cantoni F, Civallero P, et al. Short stature in children with coeliac disease. Pediatr Endocrinol Rev 2009;6:457–63. [PubMed]

  • 11.

    Assiri AM. Isolated short stature as a presentation of celiac disease in Saudi children. Pediatr Rep 2010;2:e4. [Crossref] [PubMed]

  • 12.

    Vanderschueren L, Wolter R, Molla A, Eggermont E, Eeckels R. Plasma growth hormone in coeliac disease. Helv Paediatr Acta 1973;28:349–57.

  • 13.

    Peracchi M, Molteni N, Cantalamessa L, Bardella MT, Peracchi G, et al. Abnormal growth hormone responsiveness to stimuli in women with active celiac sprue. Am J Gastroenterol 1992;87:580–3. [PubMed]

  • 14.

    Lecornu M, David L, Francois R. Low serum somatomedin activity in celiac disease: a misleading aspect in growth failure from asymptomatic celiac disease. Helv Paediatr Acta 1978;33: 509–16. [PubMed]

  • 15.

    Bresson JL, Prevot C, Rappaport R, Czernichow P, Schmitz J, et al. [Circulating somatomedin activity and growth hormone secretion: changes during late diagnosed celiac disease and effects of treatment]. Arch Fr Pediatr 1979;36:XIII–VIII.

  • 16.

    Federico G, Favilli T, Cinquanta L, Ughi C, Saggese G. Effect of celiac disease and gluten-free diet on growth hormone-binding protein, insulin-like growth factor-I, and insulin-like growth factor-binding proteins. Horm Res 1997;48:108–14. [PubMed] [Crossref]

  • 17.

    Dickey W, Kearney N. Overweight in celiac disease: prevalence, clinical characteristics, and effect of a gluten-free diet. Am J Gastroenterol 2006;101:2356–9. [Crossref] [PubMed]

  • 18.

    Owen DA, Thorlakson TK, Walli JE. Celiac disease in a patient with morbid obesity. Arch Intern Med 1980;140:1380–1. [Crossref]

  • 19.

    Semeraro LA, Barwick KW, Gryboski JD. Obesity in celiac sprue. J Clin Gastroenterol 1986;8:177–80. [PubMed] [Crossref]

  • 20.

    Conti Nibali S, Magazzu G, De Luca F. Obesity in a child with untreated coeliac disease. Helv Paediatr Acta 1987;42:45–8.

  • 21.

    Czaja-Bulsa G, Garanty-Bogacka B, Syrenicz M, Gebala A. Obesity in an 18-year-old boy with untreated celiac disease. J Pediatr Gastroenterol Nutr 2001;32:226. [Crossref]

  • 22.

    Franzese A, Iannucci MP, Valerio G, Ciccimarra E, Spaziano M, et al. Atypical celiac disease presenting as obesity-related liver dysfunction. J Pediatr Gastroenterol Nutr 2001;33:329–32. [PubMed] [Crossref]

  • 23.

    Shalitin S, Phillip M. Role of obesity and leptin in the pubertal process and pubertal growth – a review. Int J Obes Relat Metab Disord 2003;27:869–74. [Crossref] [PubMed]

  • 24.

    Lustig RH, Weiss, R. Pediatric endocrinology, 3rd ed. Philadelphia: Saunders, 2008.

  • 25.

    Jin L, Burguera BG, Couce ME, Scheithauer BW, Lamsan J, et al. Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab 1999;84:2903–11. [Crossref] [PubMed]

  • 26.

    Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Junien JL, et al. In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms. Endocrinology 2000;141:1464–9. [Crossref] [PubMed]

  • 27.

    Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997;94:1023–8. [Crossref]

  • 28.

    Maor GR, Segev Y, Phillip M. Leptin acts as a growth factor on the chondrocytes of skeletal growth centers. J Bone Miner Res 2002;17:1034–43. [Crossref] [PubMed]

  • 29.

    Biason-Lauber A, Zachmann M, Schoenle EJ. Effect of leptin on CYP17 enzymatic activities in human adrenal cells: new insight in the onset of adrenarche. Endocrinology 2000;141:1446–54.

  • 30.

    Genazzani AR, Pintor C, Corda R. Plasma levels of gonadotropins, prolactin, thyroxine, and adrenal and gonadal steroids in obese prepubertal girls. J Clin Endocrinol Metab 1978;47:974–9. [PubMed] [Crossref]

  • 31.

    De Simone M, Farello G, Palumbo M, Gentile T, Ciuffreda M, et al. Growth charts, growth velocity and bone development in childhood obesity. Int J Obes Relat Metab Disord 1995;19:851–7. [PubMed]

  • 32.

    Ravelli A, Bolognini S, Gambarotti M, Villanacci V. Variability of histologic lesions in relation to biopsy site in gluten-sensitive enteropathy. Am J Gastroenterol 2005;100:177–85. [PubMed] [Crossref]

  • 33.

    Kav T, Sivri B. Is enteroscopy necessary for diagnosis of celiac disease? World J Gastroenterol 2012;18:4095–101. [Crossref] [PubMed]

  • 34.

    Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005;40:1–19. [Crossref]

  • 35.

    Barlow SE. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007;120(Suppl 4):S164–92.

  • 36.

    Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, et al. 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11 2002:1–190.

  • 37.

    Wales JK, Wit J-M, Rogol AD. Pediatric endocrinology and growth, 2nd ed. New York: Saunders Scientific Publications, 2002.

  • 38.

    Killeen J, Vanderburg D, Harlan WR. Application of weight-height ratios and body indices to juvenile populations – the National Health Examination Survey Data. J Chronic Dis 1978;31: 529–37. [PubMed] [Crossref]

  • 39.

    Himes JH, Roche AF. Subcutaneous fatness and stature: relationship from infancy to adulthood. Hum Biol 1986;58: 737–50. [PubMed]

  • 40.

    Lazarus R, Baur L, Webb K, Blyth F. Adiposity and body mass indices in children: Benn’s index and other weight for height indices as measures of relative adiposity. Int J Obes Relat Metab Disord 1996;20:406–12.

  • 41.

    Hattori K, Hirohara T. Age change of power in weight/height(p) indices used as indicators of adiposity in Japanese. Am J Hum Biol 2002;14:275–9. [Crossref] [PubMed]

  • 42.

    Freedman DS, Thornton JC, Mei Z, Wang J, Dietz WH, et al. Height and adiposity among children. Obes Res 2004;12:846–53. [Crossref] [PubMed]

  • 43.

    Cheng J, Brar PS, Lee AR, Green PH. Body mass index in celiac disease: beneficial effect of a gluten-free diet. J Clin Gastroenterol 2010;44:267–71. [Crossref] [PubMed]

  • 44.

    Ertekin V, Orbak Z, Selimoglu MA, Yildiz L. Serum leptin levels in childhood celiac disease. J Clin Gastroenterol 2006;40:906–9. [PubMed] [Crossref]

  • 45.

    Maccario M, Ramunni J, Oleandri SE, Procopio M, Grottoli S, et al. Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients. Int J Obes Relat Metab Disord 1999;23:612–8. [Crossref] [PubMed]

About the article

Corresponding author: Benjamin U. Nwosu, MD, Associate Professor, Division of Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA, Phone: +508-334-7872, Fax: +508-856-4287, E-mail:


Received: 2012-10-04

Accepted: 2013-04-15

Published Online: 2013-05-24

Published in Print: 2013-10-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0312. Export Citation

Comments (0)

Please log in or register to comment.
Log in