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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

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In This Section
Volume 26, Issue 9-10 (Oct 2013)


Association of serum resistin levels with metabolic syndrome and early atherosclerosis in obese Chinese children

Xiao-Yi Chen
  • Weifang Medical University, Weifang, China
  • Both authors equally contributed to this work.
/ Jin-Hua Zhang
  • Jinan Municipal Four Hospital, Jinan, China
  • Both authors equally contributed to this work.
/ Feng Liu
  • Qian-Fo-Shan Hospital, Shandong University, Jinan, China
/ Hong-Mei Liu
  • Qian-Fo-Shan Hospital, Shandong University, Jinan, China
/ Yi-Yan Song
  • Qian-Fo-Shan Hospital, Shandong University, Jinan, China
/ Yun-Ling Liu
  • Corresponding author
  • Qian-Fo-Shan Hospital, Shandong University, Jinan, China
  • Email:
Published Online: 2013-05-17 | DOI: https://doi.org/10.1515/jpem-2012-0326


Aim: To investigate the association of serum resistin levels with metabolic syndrome (MS) and early atherosclerosis in obese children.

Methods: A total of 176 obese children and 88 healthy children were enrolled in this study, and were gender and age matched. Obesity was defined as a body mass index (BMI) of ≥ the 95th percentile for age and sex. All children had a physical examination and routine hematology testing for fasting blood glucose, insulin, and lipids profile. Homeostasis model of assessment of insulin resistance (HOMA-IR) was calculated, as insulin resistance has a central role in the pathophysiology of MS. Non-invasive ultrasound measurement was obtained to investigate carotid intima-media thickness (IMT) as the markers of early atherosclerosis. Path analysis was used to evaluate the value of resistin levels to early atherosclerosis.

Results: The resistin levels were higher in obese children compared to healthy children (23.14±7.35 vs. 17.1±5.7 ng/mL, p<0.05), and it is positively correlated with BMI, waist circumference, systolic blood pressure, fasting insulin, HOMA-IR, IMT and high sensitive CRP (Hs-CRP), but not related to diastolic blood pressure, blood lipids and fasting glucose. A positive linear correlation was observed between resistin and the number of MS components. Path analysis indicated serum resistin can directly (β=0.304, p=0.001), and indirectly via HOMA-IR (β=0.085, p=0.008) and Hs-CRP (β=0.047, p=0.029), contribute to early atherosclerosis.

Conclusion: Resistin not only play a certain role in the presence of MS, but also indirectly via insulin resistance and Hs-CRP to contribute to early atherosclerosis in obese children.

Keywords: atherosclerosis; children; metabolic syndrome; obesity; resistin


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About the article

Corresponding author: Yun-Ling Liu, Qian-Fo-Shan Hospital, Shandong University, 16766 Jing-shi Road, Jinan, China, Phone: +86-53189268239, Fax: +86-53182963677, E-mail:

Received: 2012-10-13

Accepted: 2013-04-04

Published Online: 2013-05-17

Published in Print: 2013-10-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0326. Export Citation

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