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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

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Volume 26, Issue 9-10 (Oct 2013)

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Association of serum resistin levels with metabolic syndrome and early atherosclerosis in obese Chinese children

Xiao-Yi Chen
  • Weifang Medical University, Weifang, China
  • Both authors equally contributed to this work.
/ Jin-Hua Zhang
  • Jinan Municipal Four Hospital, Jinan, China
  • Both authors equally contributed to this work.
/ Feng Liu
  • Qian-Fo-Shan Hospital, Shandong University, Jinan, China
/ Hong-Mei Liu
  • Qian-Fo-Shan Hospital, Shandong University, Jinan, China
/ Yi-Yan Song
  • Qian-Fo-Shan Hospital, Shandong University, Jinan, China
/ Yun-Ling Liu
  • Corresponding author
  • Qian-Fo-Shan Hospital, Shandong University, Jinan, China
  • Email:
Published Online: 2013-05-17 | DOI: https://doi.org/10.1515/jpem-2012-0326

Abstract

Aim: To investigate the association of serum resistin levels with metabolic syndrome (MS) and early atherosclerosis in obese children.

Methods: A total of 176 obese children and 88 healthy children were enrolled in this study, and were gender and age matched. Obesity was defined as a body mass index (BMI) of ≥ the 95th percentile for age and sex. All children had a physical examination and routine hematology testing for fasting blood glucose, insulin, and lipids profile. Homeostasis model of assessment of insulin resistance (HOMA-IR) was calculated, as insulin resistance has a central role in the pathophysiology of MS. Non-invasive ultrasound measurement was obtained to investigate carotid intima-media thickness (IMT) as the markers of early atherosclerosis. Path analysis was used to evaluate the value of resistin levels to early atherosclerosis.

Results: The resistin levels were higher in obese children compared to healthy children (23.14±7.35 vs. 17.1±5.7 ng/mL, p<0.05), and it is positively correlated with BMI, waist circumference, systolic blood pressure, fasting insulin, HOMA-IR, IMT and high sensitive CRP (Hs-CRP), but not related to diastolic blood pressure, blood lipids and fasting glucose. A positive linear correlation was observed between resistin and the number of MS components. Path analysis indicated serum resistin can directly (β=0.304, p=0.001), and indirectly via HOMA-IR (β=0.085, p=0.008) and Hs-CRP (β=0.047, p=0.029), contribute to early atherosclerosis.

Conclusion: Resistin not only play a certain role in the presence of MS, but also indirectly via insulin resistance and Hs-CRP to contribute to early atherosclerosis in obese children.

Keywords: atherosclerosis; children; metabolic syndrome; obesity; resistin

References

  • 1.

    Brage S, Wedderkopp N, Ekelund U, Franks PW, Wareham NJ, et al. Features of the metabolic syndrome are associated with objectively measured physical activity and fitness in Danish children: the European Youth Heart Study (EYHS). Diabetes Care 2004;27:2141–8. [Crossref] [PubMed]

  • 2.

    Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005;365:1415–28.

  • 3.

    Beauloye V, Zech F, Tran HT, Clapuyt P, Maes M, et al. Determinants of early atherosclerosis in obese children and adolescents. J Clin Endocrinol Metab 2007;92:3025–32. [Crossref] [PubMed]

  • 4.

    Aquilante CL, Kosmiski LA, Knutsen SD, Zineh I. Relationship between plasma resistin concentrations, inflammatory chemokines, and components of the metabolic syndrome in adults. Metabolism 2008;57:494–501. [Web of Science] [PubMed] [Crossref]

  • 5.

    Filkova M, Haluzik M, Gay S, Senolt L. The role of resistin as a regulator of inflammation: implications for various human pathologies. Clin Immunol 2009;133:157–70. [Web of Science]

  • 6.

    Choi HY, Kim S, Yang SJ, Yoo HJ, Seo JA, et al. Association of adiponectin, resistin, and vascular inflammation: analysis with 18F-fluorodeoxyglucose positron emission tomography. Arterioscler Thromb Vasc Biol 2011;31:944–9. [Crossref] [PubMed] [Web of Science]

  • 7.

    Lee SE, Kim HS. Human resistin in cardiovascular disease. J Smooth Muscle Res 2012;48:27–35.

  • 8.

    Rajala U, Laakso M, Päivänsalo M, Pelkonen O, Suramo I, et al. Low insulin sensitivity measured by both quantitative insulin sensitivity check index and homeostasis model assessment method as a risk factor of increased intima-media thickness of the carotid artery. J Clin Endocrinol Metab 2002;87:5092–7. [Crossref] [PubMed]

  • 9.

    Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J Immunol 2005;174:5789–95.

  • 10.

    National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children adolescents. Pediatrics 2004;114 (Suppl 2):555–76.

  • 11.

    Ogawa Y, Kikuchi T, Nagasaki K, Hiura M, Tanaka Y, et al. Usefulness of serum adiponectin levels as a diagnostic marker of metabolic syndrome in obese Japanese children. Hypertens Res 2005;28:51–7. [PubMed] [Crossref]

  • 12.

    Reinehr T, Kiess W, de Sousa G, Stoffel-Wagner B, Wunsch R. Intima-media thickness in childhood obesity: relation to inflammatory marker, glucose metabolism, and blood pressure. Metabolism 2006;55:113–8. [Crossref]

  • 13.

    Wunsch R, Dudwiesus H, Reinehr T. Prospective comparison of different ultrasound modalities to measure thickness less than 1 mm. Rofo 2007;179:65–71.

  • 14.

    Unsh R, de Sousa G, Toschke AM, Reinehr T. Intima-media thickness in obese children before and after weight loss. Pediatrics 2006;118:2334–40.

  • 15.

    Maggio AB, Wacker J, Montecucco F, Galan K, Pelli G, et al. Serum resistin and inflammatory and endothelial activation markers in obese adolescents. J Pediatr 2012;161:1022–7. [Web of Science]

  • 16.

    Li M, Fisette A, Zhao XY, Deng JY, Mi J, et al. Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents. Int J Obes (Lond) 2009;33:424–39. [Web of Science] [Crossref]

  • 17.

    Yazıcı D, Yavuz D, Öğünç AV, Sirikçi Ö, Toprak A, et al. Serum adipokine levels in type 1 diabetic patients: association with carotid intima media thickness. Metab Syndr Relat Disord 2012;10:26–31. [Web of Science]

  • 18.

    Chrzaowska J, Zubkiewicz-Kucharska A, Noczynska A. Adipocytokines concentration and metabolic parameters in obese children. Pediatr Endocrinol Diabetes Metab 2011;17:145–51.

  • 19.

    Kawamoto R, Tabara Y, Kohara K, Kusunoki T, Abe M, et al. Plasma resistin levels are associated with insulin resistance in older Japanese men from a rural village. Metab Syndr Relat Disord 2012;10:380–6. [Web of Science]

  • 20.

    Singh AK, Tiwar S, Gupta A, Natu SM, Mittal B, et al. Association of resistin with metabolic syndrome in Indian subjects. Metab Syndr Relat Disord 2012;10:286–91. [Web of Science]

  • 21.

    Malo E, Ukkola O, Jokela M, Moilanen L, Kähönen M, et al. Resistin is an indicator of the metabolic syndrome according to five different definitions in the Finnish Health 2000 survey. Metab Syndr Relat Disord 2011;9:203–10. [Web of Science]

  • 22.

    Simşek E, Balta H, Balta Z, Dallar Y. Childhood obesity-related cardiovascular risk factors and carotid intima-media thickness. Turk J Pediatr 2010;52:602–11. [PubMed]

  • 23.

    Reinehr T, Wunsch R, de Sousa G, Toschke AM. Relationship between metabolic syndrome definitions for children and adolescents and intima-media thickness. Atherosclerosis 2008;199:193–200. [Web of Science] [Crossref] [PubMed]

  • 24.

    Hacihamdioğlu B, Okutan V, Yozgat Y, Yildirim D, Kocaoğlu M, et al. Abdominal obesity is an independent risk factor for increased carotid intima-media thickness in obese children. Turk J Pediatr 2011;53:48–54. [PubMed]

  • 25.

    Roh EJ, Lim JW, Ko KO, Cheon EJ. A useful predictor of early atherosclerosis in obese children: serum high-sensitivity C-reactive protein. J Korean Med Sci 2007;22:192–7. [Web of Science] [PubMed] [Crossref]

  • 26.

    Fang J, Zhang JP, Luo CX, Yu XM, Lv LQ. Carotid intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance. Int J Med Sci 2010;7:278–83. [PubMed] [Crossref]

  • 27.

    Rae C, Graham A. Human resistin promotes macrophage lipid accumulation. Diabetologia 2006;49:1112–4. [Crossref] [PubMed]

  • 28.

    Mu H, Ohashi R, Yan S, Chai H, Yang H, et al. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res 2006;70:146–57. [PubMed] [Crossref]

  • 29.

    Calabrò P, Cirillo P, Limongelli G, Maddaloni V, Riegler L, et al. Tissue factor is induced by resistin in human coronary artery endothelial cells by the NF-κB-dependent pathway. J Vasc Res 2011;48:59–66. [Crossref] [Web of Science] [PubMed]

  • 30.

    Nakata M, Okada T, Ozawa K, Yada T. Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release. Biochem Biophys Res Commun 2007;353:1046–51. [Web of Science]

  • 31.

    Giannini C, de Giorgis T, Scarinci A, Ciampani M, Marcovecchio ML, et al. Obese related effects of inflammatory markers and insulin resistance on increased carotid intima media thickness in pre-pubertal children. Atherosclerosis 2008;197:448–56.

About the article

Corresponding author: Yun-Ling Liu, Qian-Fo-Shan Hospital, Shandong University, 16766 Jing-shi Road, Jinan, China, Phone: +86-53189268239, Fax: +86-53182963677, E-mail:


Received: 2012-10-13

Accepted: 2013-04-04

Published Online: 2013-05-17

Published in Print: 2013-10-01



Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2012-0326. Export Citation

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