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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

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Detection of vascular risk markers in children and adolescents with type 1 diabetes

Heves Kırmızıbekmez
  • Corresponding author
  • Göztepe Educational and Research Hospital, Clinics of Pediatric Endocrinology, Istanbul, Turkey
  • Email:
/ Ayla Güven
  • Göztepe Educational and Research Hospital, Clinics of Pediatric Endocrinology, Istanbul, Turkey
/ Metin Yıldız
  • Göztepe Educational and Research Hospital, Clinics of Pediatric Endocrinology, Istanbul, Turkey
/ Fatma Dursun
  • Göztepe Educational and Research Hospital, Clinics of Pediatric Endocrinology, Istanbul, Turkey
/ Nurcan Cebeci
  • Göztepe Educational and Research Hospital, Clinics of Pediatric Endocrinology, Istanbul, Turkey
/ Suna Hancili
  • Göztepe Educational and Research Hospital, Clinics of Pediatric Endocrinology, Istanbul, Turkey
Published Online: 2013-08-14 | DOI: https://doi.org/10.1515/jpem-2013-0046


Objectives: Type 1 diabetes is a chronic disease that causes persistent vascular injury. This study investigates the benefits of surrogate markers in early detection of vascular injury in children and adolescents with type 1 diabetes.

Methods: Eighty-four patients (35 male, 49 female) with type 1 diabetes for 5 or more years were included. Serum lipid profile, plasminogen activator inhibitor-1 (PAI-1), lipoprotein (a) (Lpa) and homocystein, were investigated. Patients were divided into two groups according to the duration of diabetes. Patients with and without microvascular complications were also compared.

Results: Microvascular complications were present in 14 out of 48 patients in group-1 (29.1%; duration of diabetes: 5–10 years) and in 7 out of 36 patients in group-2 (19.4%; duration of diabetes: >10 years). Serum homocystein, Lpa, PAI-1 and serum lipids were not correlated with the duration of diabetes. Significantly increased triglyceride (TG) and HbA1C levels were associated with the presence of microvascular complications.

Conclusion: Providing good glycemic control is very important for preventing vascular injury in children and adolescents with type 1 diabetes. It seems that traditional vascular surrogate markers like LDL/HDL ratio, triglycerides and HbA1C level correspond more to microvascular complications than newly defined surrogate markers that are not commonly available.

Keywords: children and adolescents; type 1 diabetes; vascular complications


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About the article

Corresponding author: Dr. Heves Kırmızıbekmez, Göztepe Educational and Research Hospital, Clinics of Pediatric Endocrinology, Dr Erkin Caddesi, Kadıköy, Istanbul, Turkey, Phone: +90 216 3910680 (1374), Fax: +90 216 3910690, E-mail:

Received: 2012-11-28

Accepted: 2013-07-16

Published Online: 2013-08-14

Published in Print: 2014-01-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2013-0046. Export Citation

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