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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

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Preterm ovarian hyperstimulation syndrome presented with vaginal bleeding: a case report

1 / Canan Turkyilmaz2 / Ozge Yuce3 / Ferit Kulali2 / Ibrahim Murat Hirfanoglu2 / Esra Onal2 / Ebru Ergenekon2 / Esin Koç2 / Aysun Bideci3 / Yıldız Atalay2

1Department of Neonatology, Gazi University Medical Faculty, 06039, Ankara, Turkey

2Faculty of Medicine, Department of Neonatology, Gazi University, Ankara, Turkey

3Faculty of Medicine, Department of Pediatric Endocrinology, Gazi University, Ankara, Turkey

Corresponding author: Nilgun Altuntas, Department of Neonatology, Gazi University Medical Faculty, 06039, Ankara, Turkey, Phone: +90-532-3005040, Fax: +90-312-2379348, E-mail:

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 27, Issue 3-4, Pages 355–358, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2013-0166, October 2013

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Preterm ovarian hyperstimulation syndrome (POHS) is an uncommon disorder characterized by prematurity, hypogastric and upper leg swelling of various intensities, high serum estradiol and gonadotropin levels, and ovarian follicular cyst/cysts. In this paper, we present the first case of POHS presenting with vaginal bleeding. A female infant was born via spontaneous vaginal delivery at 25 weeks of gestation with a birth weight of 610 g. At 36 weeks of post-conception age, she developed breast enlargement, swelling of the clitoral hood, labia major and minor, hypogastrium and upper legs. Several weeks later, vaginal bleeding started and lasted 3 days. The vaginal bleeding continued to occur at monthly intervals. The elevated levels of gonadotropins and estrogens, vulvar swelling and cysts in both ovaries confirmed the diagnosis of preterm ovarian hyperstimulation syndrome.

Keywords: ovarian hyperstimulation syndrome; preterm infants; vulvar swelling


Preterm ovarian hyper stimulation syndrome (POHS) is a very rare entity characterized by vulvar, hypogastric and upper leg swelling, elevated serum estradiol (E2) and gonadotropin levels, and ovarian follicular cysts (1–3). The main etiopathology is the immaturity of the gonadal axis and the lack of the negative feedback of the placental steroids.

The major sign of POHS is vulvar, hypogastric, and upper leg swelling independent from E2 levels. Thus, it is generally diagnosed when swelling is profound. The extent of estrogen-induced changes is inconsistent in the literature. Herein, we aim to describe a case with slightly higher degree of hyperestrogenization than observed in cases reported previously.

Case report

A premature female infant was born via spontaneous vaginal delivery at 25 weeks of gestation with a birth weight of 610 g. The preterm birth was as a result of cervical insufficiency. Her birth weight was suitable for gestational age. Apgar scores were 5 and 8, at 1 and 5 min, respectively. She was followed up at the Neonatal Intensive Care Unit because of prematurity respiratory distress syndrome, sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, cystic periventricular leukomalacia, and hypothyroxinemia. At 36 weeks of post-conception age (WPCA), she developed breast enlargement (Tanner II), swelling of the clitoral hood, labia major and minor, hypogastrium and upper legs (Figure 1). Several weeks later (at 39 WPCA), vaginal bleeding started and lasted 3 days. The vaginal bleeding continued to occur at monthly intervals. The ultrasound and computed tomography imaging of the abdomen and minor pelvis were normal.

Figure 1

Photograph of the genitalia at 37 weeks. Engorgement labia majora and minora, a swollen clitoral hood and vaginal hemorrhage.

The differential diagnoses including estrogen producing tumor, exogenous estrogen display and McCune-Albright syndrome (MAS) were excluded. MAS is suspected when two of the three following features are present: (i) polyostotic fibrous dysplasia (PFD); (ii) café-au-lait skin pigmentation; and (iii) autonomous endocrine hyperfunction (e.g., gonadotropin-independent precocious puberty and hyperthyroidism). Laboratory evaluation of the baby showed high concentrations of E2 [316 pg/mL (reference range <56 pg/mL)], follicle stimulating hormone (FSH) [8.34 IU/L (reference range=0.2–6.6 IU/L)], and luteinizing hormone (LH) [13.18 IU/L (reference range=0.1–6 IU/L)]. Her bone age was compatible with her chronological age. The cranial magnetic resonance imaging revealed hypoplasia of the right cerebellar hemisphere and asymmetric appearance of the frontal horn of left lateral ventricle. The pituitary size was normal. L-tiroksin treatment (5 μg/kg/day) was started due to transient hypothroxinemia [TSH level; 4.25 μIU/mL (reference range=1.0–4.80 μIU/mL) and free T4 level; 0.4 ng/dL (reference range=0.7–1.48 ng/dL)] at postnatal second week and continued for 6 months.

The pelvic and abdominal ultrasonography examinations revealed enlarged uterus (2.2×1.4×2.7 cm) with an endometrial stripe of 4.5 mm and multiple small cysts in the left ovary with a maximum diameter of 1.5×0.9 cm. A cyst with a diameter of 3.1×1.7 cm was also present in the right ovary (Figure 2). The elevated levels of gonadotropins and estrogens, vulvar swelling and cysts in both ovaries confirmed the diagnosis of preterm ovarian hyperstimulation syndrome.

Figure 2

Longitudinal ultrasound view of the infant’s pelvis with large ovarian cyst.

Laboratory examinations were performed to monitor changes in the hormonal levels, and at PGA of 52 weeks, serum levels of the concentrations of estrogens and gonadotropins returned to normal infant range. Consecutive pelvic ultrasonography revealed the regression of the ovarian cysts. Breast enlargement regressed to Tanner I and vaginal bleeding ceased in 2 months (at 44 WPCA), and swellings improved in 3 months (at 48 WPCA). Clinical and laboratory findings were normal at 52 WPCA. She is currently 18 months old and both her clinical and laboratory values are completely normal.


Preterm ovarian hyperstimulation syndrome was first described in 1985 (1). It has been rarely reported in medical literature until this time (1, 2, 4). The characteristic features include prematurity (24–31 WPCA), swelling of vulva, hypogastric region and upper leg, elevation of E2 and gonodotrophin, and multiple cysts in both ovaries (2, 5). The only pathognomonic sign of POHS is the swelling of the vulva occurring as a result of high levels of vascular endothelial growth factors secreted by theca and granulose cells (2).

Ovarian cysts are not specific for POHS. Single or multiple follicular cysts are relatively common (30%–34%) in healthy fetuses and newborn infants (1–3). Fifty percent of these cysts regress spontaneously in the first month of life with another 25% disappearing by the end of the second month (6). The origin of ovarian cysts is still a controversial topic. Meizner et al. showed excessive stimulation of fetal ovaries by placental or maternal hormones (7). Fetal ovarian cysts are frequently associated with a large placenta with a consequent increase in hCG production (8–11). Infrequently, a postnatal surge of gonadotropins possibly due to the infantile ovarian dysfunction can produce overstimulation of the ovaries with cyst formation and estrogen production in healthy neonates and preterm infants.

High level E2 and gonadotropin are not specific for POHS, either. Fetal gonadotropins decrease during the last trimester of pregnancy, but increase after birth. This transient increase of gonadotropin levels after birth is known as the mini-puberty (12). FSH and LH levels in the newborn peak at 3 to 4 months of age and then subsequently decrease, reaching prepubertal levels at 2–3 years of age (13, 14). This may be as a result of an immaturity of the hypothalamic-pituitary-gonadal (HPG) axis, the lack of negative feedback on axis and rapid withdrawal of placental sex steroids (15). Changes of gonadotropin surge is more marked and prolonged in preterm infants (16). However, our knowledge about postnatal developmental changes in the HPG axis and gonadotropin levels is limited, especially in older preterm infants. Our patient had high gonadotropin levels but high free FSH and LH levels are not sufficient to discriminate between the diagnoses of POHS and mini-puberty.

We made the diagnoses of POHS in our patient as she had swelling of vulva and hypogastrium and upper leg that is not seen healthy newborns and preterm infants in mini puberty.

Although they have high E2 concentrations, estrogenization signs varies in POHS cases. In the present case, we did not observe any high E2 concentration-dependent accelerated growth and bone maturation. This condition has been explained by decreased peripheral E2 receptor sensitivity that is a result of immature gonadal axis (12, 17). In contrast to this hypothesis, the initial signs were the breast enlargement (Tanner II) and vaginal bleeding in addition to swellings in our case. To our knowledge, our patient is the first case presenting with vaginal bleeding and the third case presenting with breast enlargements in the literature (2, 5).

Autonomous ovarian cysts may cause vaginal bleeding. However, it is difficult to attribute the vaginal bleeding in our patient to the presence of the autonomous cyst alone as vaginal bleeding continued to occur during cyst regression.

The first line approach for treatment of neonatal and infantile ovarian cysts in POHS patients is to follow-up patients without any treatment unless there is a risk of torsion, rupture and hemorrhage of the cyst. Surgical removal of the ovarian cyst should be performed in the presence of these complications. Ultrasound-guided aspiration of large neonatal ovarian cysts may be attempted prior to surgical exploration (18, 19).

Our case was followed up regularly to assess growth and regression of ovarian cysts. The size and the number of the cysts regressed on follow-up ultrasound imaging over time. Both laboratory and clinical findings returned to normal at 52 WPCA (in 16 weeks).

In conclusion, POHS has a widespread hyperostrogenization symptom spectrum. Vaginal bleeding has never been reported before and breast enlargement in only two newborn cases with POHS. These major signs in addition to common findings of POHS in our patient improved without treatment. This case may illustrate that POHS might appear with different presentations and POHS does not require any therapy in the absence of cyst torsion.


  • 1.

    Sedin G, Bergquist C, Lindgren PG. Ovarian hyperstimulation syndrome in preterm infants. Pediatr Res 1985;19:548–52. [PubMed] [Crossref]

  • 2.

    Starzyk J, Wójcik M, Wojtyś J, Tomasik P, Mitkowska Z, et al. Ovarian hyperstimulation syndrome in newborns-a case presentation and literature review. Horm Res 2009; 71:60–4. [Web of Science] [PubMed] [Crossref]

  • 3.

    Doshi N, Fujikura T, Kaubour A. Vaginal adenosis and polycystic overies during infancy and childhood. Am J Obstet Gynecol 1977;129:374–8.

  • 4.

    Vochem M. Ovarian hyperstimulation syndrome in preterm infants. Z Geburtshilfe Neonatol 2002;206:156–60.

  • 5.

    Marinkovic M, Rasmussen M, Jones K. Feminizing changes in a prematurely born infant. Clin Pediatr 2010;49:188–9. [Web of Science] [Crossref]

  • 6.

    Templeman C. Ovarian cysts. J Pediatr Adolesc Gynecol 2004;17:297–8. [PubMed] [Web of Science]

  • 7.

    Meizner I, Levy A, Katz M, Maresh AJ, Glezerman M. Fetal ovarian cysts: prenatal ultrasonographic detection and postnatal evaluation and treatment. Am J Obstet Gynecol 1991;164:874–8.

  • 8.

    deSa DJ. Follicular ovarian cysts in stillbirths and neonates. Arch Dis Child 1975;50:45–50. [PubMed]

  • 9.

    Ahlvin R, Bauer WC. Luteinized cysts in ovaries of infants born of diabetic mothers. Am J Dis Child 1957;93:107–10.

  • 10.

    McCarthy C, Pennington GW. Maternal chorionic gonadotropin concentration as an aid to the antenatal prediction of hemolytic disease of newborn infants. Am J Obstet Gynecol 1964;89: 1069–72. [PubMed]

  • 11.

    Pryse-Davies J. Dewhurst CJ. The development of the ovary and uterus in the fetus, newborn and infant: a morphological and enzyme histochemical study. J Pathol 1971; 103:5–25.

  • 12.

    Shinkawa O, Furuhashi N, Fukaya T, Suzuki M, Kono H, et al. Changes of serum gonadotropin levels and sex differences in premature and mature infant during neonatal life. J Clin Endocrinol Metab 1983;56:1327–31. [Crossref] [PubMed]

  • 13.

    Dolgin SE. Ovarian masses in the newborn. Semin Pediatr Surg 2000;9:121–7. [Crossref] [PubMed]

  • 14.

    Vogtlander MF, Rijntjes-Jacobs EG, van den Hoonard TL, Versteegh FG. Neonatal ovarian cysts. Acta Paediatr 2003;92:498–501.

  • 15.

    Greaves RF, Hunt RW, Chiriano AS, Zacharin MR. Luteinizing hormone and follicle-stimulating hormone levels in extreme prematurity: development of reference intervals. Pediatrics 2008;121:e574–80. [Web of Science]

  • 16.

    Kuiri-Hänninen T, Kallio S, Seuri R, Tyrväinen E, Liakka A, et al. Postnatal developmental changes in the pituitary-ovarian axis in preterm and term infant girls. J Clin Endocrinol Metab 2011;96:3432–9. [Crossref] [Web of Science]

  • 17.

    Achermann JC. Endocrinology of the newborn. In: Brook C, Clayton P, Brown R, editors. Brook’s clinical pediatric endocrinology, 5th ed. Oxford: Blackwell Publishing, 2005:153–70.

  • 18.

    Luzzatto C, Midrio P, Toffolutti T, Suma V. Neonatal ovarian cysts: management and follow-up. Pediatr Surg Int 2000;16:56–9. [PubMed] [Crossref]

  • 19.

    Comparetto C, Giudici S, Coccia ME, Scarselli G, Borruto F. Fetal and neonatal ovarian cysts: what’s their real meaning? Clin Exp Obstet Gynecol 2005;32:123–5.

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