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Journal of Pediatric Endocrinology and Metabolism

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Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval

Assimina Galli-Tsinopoulou
  • Corresponding author
  • Faculty of Medicine, 4th Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece
  • Email:
/ Aikaterini Chatzidimitriou
  • Faculty of Medicine, 4th Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece
/ Ioannis Kyrgios
  • Faculty of Medicine, 4th Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece
/ Israel Rousso
  • Faculty of Medicine, 2nd Department of Pediatrics, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
/ George Varlamis
  • Faculty of Medicine, 4th Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece
/ Kyriaki Karavanaki
  • Faculty of Medicine, 2nd Department of Pediatrics, National and Kapodestrian University of Athens, “P&A Kyriakou” Children’s Hospital, Athens, Greece
Published Online: 2013-10-14 | DOI: https://doi.org/10.1515/jpem-2013-0193


Background: QT-wave abnormalities have been detected in type 1 diabetes mellitus (T1DM). Prolongation of the heart rate corrected QT interval (QTc) has been associated with cardiovascular mortality. We evaluated how often QT/QTc abnormalities are present in youth with T1DM and if they are associated with disease parameters.

Methods: Sixty-two T1DM youngsters and equal age- and gender-matched controls were studied. Demographic, anthropometric, and laboratory data were determined. QT was measured on a 12-lead resting electrocardiogram. QTc was calculated using Bazett’s formula.

Results: T1DM patients had significantly longer QT/QTc than controls, but significance disappeared after adjustment for confounders. Abnormally prolonged QTc≥440 ms was observed six times more frequently in those with T1DM. QT was correlated with age, age at disease onset, but not with glycated hemoglobin or diabetes duration; QTc was only correlated with pubertal stage.

Conclusions: T1DM youths have a sixfold increased risk for QT/QTc prolongation and should have regular follow-up for cardiac autonomic dysfunction.

Keywords: children and adolescents; electrocardiographic abnormalities; QTc interval; QT interval; type 1 diabetes mellitus


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About the article

Corresponding author: Assimina Galli-Tsinopoulou, Faculty of Medicine, 4th Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Ring Road Nea Efkarpia, 564 03 Thessaloniki, Greece, Phone: +30 2310 991537, Fax: +30 2310 991537, E-mail:

Received: 2013-05-18

Accepted: 2013-09-11

Published Online: 2013-10-14

Published in Print: 2014-03-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2013-0193. Export Citation

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