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Roth, Christian

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

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Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval

1 / Aikaterini Chatzidimitriou1 / Ioannis Kyrgios1 / Israel Rousso2 / George Varlamis1 / Kyriaki Karavanaki3

1Faculty of Medicine, 4th Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece

2Faculty of Medicine, 2nd Department of Pediatrics, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece

3Faculty of Medicine, 2nd Department of Pediatrics, National and Kapodestrian University of Athens, “P&A Kyriakou” Children’s Hospital, Athens, Greece

Corresponding author: Assimina Galli-Tsinopoulou, Faculty of Medicine, 4th Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Ring Road Nea Efkarpia, 564 03 Thessaloniki, Greece, Phone: +30 2310 991537, Fax: +30 2310 991537, E-mail:

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 27, Issue 3-4, Pages 237–243, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2013-0193, October 2013

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Background: QT-wave abnormalities have been detected in type 1 diabetes mellitus (T1DM). Prolongation of the heart rate corrected QT interval (QTc) has been associated with cardiovascular mortality. We evaluated how often QT/QTc abnormalities are present in youth with T1DM and if they are associated with disease parameters.

Methods: Sixty-two T1DM youngsters and equal age- and gender-matched controls were studied. Demographic, anthropometric, and laboratory data were determined. QT was measured on a 12-lead resting electrocardiogram. QTc was calculated using Bazett’s formula.

Results: T1DM patients had significantly longer QT/QTc than controls, but significance disappeared after adjustment for confounders. Abnormally prolonged QTc≥440 ms was observed six times more frequently in those with T1DM. QT was correlated with age, age at disease onset, but not with glycated hemoglobin or diabetes duration; QTc was only correlated with pubertal stage.

Conclusions: T1DM youths have a sixfold increased risk for QT/QTc prolongation and should have regular follow-up for cardiac autonomic dysfunction.

Keywords: children and adolescents; electrocardiographic abnormalities; QTc interval; QT interval; type 1 diabetes mellitus

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