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Licensed Unlicensed Requires Authentication Published by De Gruyter February 27, 2014

Circulating intact parathyroid hormone is suppressed at 25-hydroxyvitamin D concentrations >25 nmol/L in children

  • Bridgit O. Crews , Jennifer Moore and Dennis J. Dietzen EMAIL logo

Abstract

Vitamin D status is best reflected by circulating concentrations of 25-hydroxyvitamin D2 and D3 (25-OH-D). An adequate blood concentration of total 25-OH-D is commonly defined as that which maintains parathyroid hormone (PTH) within the normal range. Consensus from studies of adults with renal impairment indicates that 75 nmol/L of 25-OH-D maintains suppression of PTH. No similar consensus exists in children. We studied the correlation of PTH and 25-OH-D in 271 patients aged 2 months to 21 years (mean 11 years) in a tertiary care pediatric setting. Patients with renal impairment were excluded by elevated creatinine concentration and chart review. PTH did not significantly correlate with 25-OH-D concentrations >25 nmol/L. PTH was significantly elevated in specimens with <25 nmol/L of 25-OH-D (p=10–17). Using PTH suppression as indicator, these data suggest that 25-OH-D concentrations >25 nmol/L in children indicate vitamin D sufficiency.


Corresponding author: Dr. Dennis J. Dietzen, Associate Professor of Pediatrics, Washington University School of Medicine Box 8116, One Children’s Place, Room 2N68, St. Louis, MO 63110, USA, Phone: +1 314 2862857, Fax: +1 314 4242274, E-mail:

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Received: 2014-1-10
Accepted: 2014-1-15
Published Online: 2014-2-27
Published in Print: 2014-7-1

©2014 by Walter de Gruyter Berlin/Boston

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