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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma

IMPACT FACTOR 2018: 1.239

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Volume 29, Issue 1


Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder

Fatih Gurbuz / Berrak Bilginer Gurbuz / Gonca Gul Celik / Veli Yildirim / Seyit Ahmet Ucakturk
  • Ankara Pediatric Hematology Oncology Training and Research Hospital, Pediatric Endocrinology, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gulsah Seydaoglu / Eda Mengen UcakturkORCID iD: http://orcid.org/0000-0003-1597-8418 / Ali Kemal Topaloglu / Bilgin Yuksel
Published Online: 2015-08-15 | DOI: https://doi.org/10.1515/jpem-2015-0171


The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7–14 years. Following treatment, patients’ leptin levels increased and ghrelin levels decreased while no significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.

Keywords: appetite; attention deficit and hyperactivity; ghrelin; growth; leptin; methylphenidate; nesfatin-1


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About the article

Corresponding author: Fatih Gurbuz, MD, Number of ESPE Membership: 123115 Cukurova University Medical Faculty, Department of Pediatric Endocrinology, Adana 01330, Turkey, Tel: +90 322 3386060 /3252, Mobile phone: +09 505 7077366, Fax: +90 322 3387717, E-mail:

Received: 2015-04-22

Accepted: 2015-07-20

Published Online: 2015-08-15

Published in Print: 2016-01-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 1, Pages 85–92, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2015-0171.

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