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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Ogata, Tsutomu / Toppari, Jorma

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2191-0251
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Volume 29, Issue 3

Issues

Value of the intrarenal arterial resistivity indices and different renal biomarkers for early identification of diabetic nephropathy in type 1 diabetic patients

Soha Abd El Dayem
  • Corresponding author
  • Consultant of Diabetes and Endocrinology, Medical Research Division, National Research Centre, Pediatrics Department, Cairo, Egypt
  • Email
  • Other articles by this author:
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/ Abo El magd El Bohy / Amal El Shehaby
Published Online: 2015-12-17 | DOI: https://doi.org/10.1515/jpem-2014-0397

Abstract

Background: The aim of this study was to compare resistivity index (RI) in type 1 diabetic patients and normal controls and to evaluate whether high RI is associated with different biomarkers of diabetic nephropathy (DN) as early detection of DN offers the best chance of delaying or possibly preventing progression to end-stage renal disease.

Methods: The study included 62 type 1 diabetic patients and 30 healthy volunteers of the same age and sex. Blood samples were taken for assessment of glycosylated hemoglobin, lipid profile and urine samples were taken for assessment of albumin/creatinine ratio, neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP) and kidney injury molecule-1 (Kim-1). Forty-five diabetic patients and 30 controls had a renal Doppler ultrasonography. t-Test or Mann Whitney U-test for independent variables, Pearson’s or Spearman correlation analysis were used.

Results: The mean age of diabetic patients was 16.3±1.5 years, and mean duration of diabetes was 9.4±2.9 years. RI, albumin/creatinine ratio, NGAL, Kim-1 and L-FABP were significantly higher in diabetics than in controls. RI, NGAL, Kim-1, and L-FABP were significantly higher in microalbuminuric compared to normoalbuminuric diabetics. In normoalbuminuric diabetics, RI, NGAL, Kim-1 and L-FABP were significantly higher compared to controls. The study revealed significant positive correlation between the RI in diabetics and both KIM-1 and albumin/creatinine ratio.

Conclusions: Increased RI and renal biomarkers in diabetics are early sensitive specific markers of DN, even preceded the development of microalbuminuria, denoting that they can be used as an early and sensitive markers for early detection of DN.

Keywords: Kim-1; L-FABP; neutrophil gelatinase-associated lipocalin (NGAL); renal Doppler; type 1 diabetes

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About the article

Corresponding author: Soha Abd El Dayem, Professor of Pediatrics, Consultant of Diabetes and Endocrinology, Medical Research Division, National Research Centre, Pediatrics Department, Cairo, Egypt, Phone: +2 01006716852, E-mail:


Received: 2014-09-21

Accepted: 2015-08-27

Published Online: 2015-12-17

Published in Print: 2016-03-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 3, Pages 273–279, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2014-0397.

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