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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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2191-0251
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Volume 29, Issue 3

Issues

The relation of urinary bisphenol A with kisspeptin in girls diagnosed with central precocious puberty and premature thelarche

İlker Tolga Özgen
  • Division of Pediatric Endocrinology, Bezmialem Vakif University Medical Faculty, Department of Pediatrics, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Emel Torun
  • Corresponding author
  • Division of Pediatric Endocrinology, Bezmialem Vakif University Medical Faculty, Department of Pediatrics, Istanbul, Turkey
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bilge Bayraktar-Tanyeri / Erdem Durmaz
  • Division of Pediatric Endocrinology, Isifa University Bornova Health and Department of Pediatrics, Izmir, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Elif Kılıç
  • Bezmialem Vakif University Medical Faculty, Department of Clinical Biochemistry, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yaşar Cesur
  • Division of Pediatric Endocrinology, Bezmialem Vakif University Medical Faculty, Department of Pediatrics, Istanbul, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-11-13 | DOI: https://doi.org/10.1515/jpem-2015-0235

Abstract

Background: Bisphenol A (BPA) is known as an endocrine disruptor and it is supposed to have a role on the development of central precocious puberty (CPP). Kisspeptin, a hypothalamic peptide, is a neuromodulator of gonadotropin releasing hormone and it has an important role on regulation of the onset of puberty. The BPA levels in girls with CPP and premature thelarche (PT) and its relation with kisspeptin levels were investigated.

Methods: Twenty-eight girls with CPP, 28 girls with PT and 22 prepubertal girls as a control group were enrolled to the study. Urinary BPA and serum kisspeptin levels were compared in the groups. Bivariate correlations were performed to evaluate the relations of BPA with kisspeptin and estradiol.

Results: There was no statistical difference between groups regarding BPA levels. Serum kisspeptin levels were higher in CPP group than controls [306.56 (interquartile range (IQR), 175.63–504.66) vs. 157.62 (IQR, 55.61–285.00) p: 0.008]. There were no correlations between BPA and kisspeptin levels (r: 0.088, p: 0.391) and between BPA and estradiol (r: –0.171, p: 0.144).

Conclusions: The BPA levels did not differentiate between groups and it seems that the exposed amount of BPA in daily life did not affect kisspeptin levels in girls with CPP and PT.

Keywords: bisphenol A; kisspeptin; precocious puberty; premature thelarche

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About the article

Corresponding author: Emel Torun, Division of Pediatric Endocrinology, Bezmialem Vakif University Medical Faculty, Department of Pediatrics, Vatan Street, Fatih, Istanbul, Turkey, Mobile: +905324652836, E-mail:


Received: 2015-06-12

Accepted: 2015-09-30

Published Online: 2015-11-13

Published in Print: 2016-03-01


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 3, Pages 337–341, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2015-0235.

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