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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma

IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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Volume 29, Issue 5


Urate crystals deposition in the feet of overweight juveniles and those with symptomatic hyperuricemia: a dual-energy CT study

Nan Sun / Shiling Zhong
  • Department of Pediatric Rheumatoid Immunity, Ningbo Women and Children’s Hospital, Ningbo, P.R. China
  • Other articles by this author:
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/ Yunyan Li
  • Department of Pediatric Rheumatoid Immunity, Ningbo Women and Children’s Hospital, Ningbo, P.R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ling Wu
  • Department of Pediatric Rheumatoid Immunity, Ningbo Women and Children’s Hospital, Ningbo, P.R. China
  • Other articles by this author:
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/ Yazhen Di
  • Corresponding author
  • Department of Pediatric Rheumatoid Immunity, Ningbo Women and Children’s Hospital, 339 Liuting Street, Ningbo, Zhejiang 315012, P.R. China, Phone: +86-574-83887082
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Published Online: 2016-03-16 | DOI: https://doi.org/10.1515/jpem-2015-0290


Background: The present study evaluated the clinical value of dual-energy computed tomography (DECT) for detecting urate crystals in juveniles with symptomatic hyperuricemia.

Methods: We recruited 24 juveniles (15 male and 9 female) who presented with symptomatic hyperuricemia. The mean body mass index (BMI) was 26.4 kg/m2 (standard deviation, SD 11.3 kg/m2). Fifteen juveniles (71.4%) were overweight. DECT scans of the feet were performed. For post-processing, a color-coding gout software protocol was used.

Results: Urate crystals deposition was observed in 21/24 (87.5%) juveniles with symptomatic hyperuricemia. Urate crystals were detected in or around the anatomic site included the first metatarsophalangeal (MTP) joints (5/24, 20.8%); the calcaneus (5/24, 20.8%); any other toe joints (3/24, 12.5%); the astragalus (3/24, 12.5%); the ankle joints (3/24, 12.5%); the metatarsals (2/24, 8.3%); the cuboid (1/24, 4.2%); and other parts of the feet (2/24, 8.3%). Importantly, urate crystals deposition weas located in the soft tissue (tendon/tendon insertion sites/entheses) around the above-mentioned sites in a majority of these patients.

Conclusions: Urate crystals deposition can be detected by dual-energy CT in the feet of symptomatic hyperuricemia juveniles. DECT can be a valuable diagnostic tool for helping diagnose in juvenile gout.

Keywords: children; dual-energy CT; hyperuricemia; joint damage; urate crystals


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About the article

Received: 2015-07-18

Accepted: 2016-01-04

Published Online: 2016-03-16

Published in Print: 2016-05-01

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 5, Pages 579–583, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2015-0290.

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