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Licensed Unlicensed Requires Authentication Published by De Gruyter March 23, 2016

Seasonality of diagnosis of type 1 diabetes mellitus in the Netherlands (Young Dudes-2)

  • Engelina A.J.M. Spaans EMAIL logo , Peter R. van Dijk , Klaas H. Groenier , Paul L.P. Brand , Maarten H. Reeser , Henk J.G. Bilo and Nanne Kleefstra

Abstract

Background: The aim of this study was to investigate seasonality in the initial presentation of type 1 diabetes mellitus (T1DM) among Dutch children.

Methods: Observational, nationwide study in the Netherlands. Using the national registry for both healthcare reimbursement and pharmaceutical care, data of all Dutch children (aged 0–14 years) with a diagnosis of T1DM in the period 2009–2011 were obtained.

Results: During the study period (2009–2011) an average annual number of 2.909.537 children aged 0–14 lived in the Netherlands and 676 children were diagnosed with T1DM per year, translating into an annual incidence rate (IR) of T1DM of 23.2 per hundred thousand children (ptc). The annual IR differed significantly (p=0.03) between seasons: 6.4 ptc in winter, 4.9 ptc in spring, 5.4 ptc in summer and 6.6 ptc in autumn. This pattern was present within both boys and girls

Conclusions: Among Dutch children aged 0–14 years, there is seasonality in the of T1DM with a peak incidence in autumn and winter.


Corresponding author: Engelina A.J.M. Spaans, MD, Diabetes Centre, Isala, PO Box 10400, 8000 GK Zwolle, The Netherlands, Phone: +31 38 4242329, Fax: +31 38 4247645, E-mail: ; and Princess Amalia Children’s Clinic, Isala, Zwolle, The Netherlands

References

1. Akerblom HK, Vaarala O, Hyöty H, Ilonen J, Knip M. Environmental factors in the etiology of type 1 diabetes. Am J Med Genet 2002;115:18–29.10.1002/ajmg.10340Search in Google Scholar

2. Stankov K, Benc D, Draskovic D. Genetic and epigenetic factors in etiology of diabetes mellitus type 1. Pediatrics 2013;132:1112–22.10.1542/peds.2013-1652Search in Google Scholar

3. Jaeckel E, Manns M, Von Herrath M. Viruses and diabetes. Ann N Y Acad Sci 2002;958:7–25.10.1111/j.1749-6632.2002.tb02943.xSearch in Google Scholar

4. Zipris D. Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanisms. Clin Immunol 2009;131:11–23.10.1016/j.clim.2008.12.011Search in Google Scholar

5. Bartsocas CS, Papadatos CJ, Lab M, Spyrou N, Krikelis B, et al. Coxsackie B viruses and autoimmune diabetes. J Pediatr 1982;101:647–9.10.1016/S0022-3476(82)80734-8Search in Google Scholar

6. Rothwell PM, Staines A, Smail P, Wadsworth E, McKinney P. Seasonality of birth of patients with childhood diabetes in Britain. Br Med J 1996;312:1456–7.10.1136/bmj.312.7044.1456Search in Google Scholar PubMed PubMed Central

7. McKinney PA, EURODIAB seasonality of birth group. Europe and Diabetes. Seasonality of birth in patients with childhood Type I diabetes in 19 European regions. Diabetologia 2001;44:B67–74.10.1007/PL00002957Search in Google Scholar PubMed

8. Jongbloet PH, Groenewoud HM, Hirasing RA, Van Buuren S. Seasonality of birth in patients with childhood diabetes in The Netherlands. Diabetes Care 1998;21:190–91.10.2337/diacare.21.1.190Search in Google Scholar PubMed

9. Neu A, Kehrer M, Ashkenazi I, Laron Z. Seasonality of birth in children (0–14 years) with diabetes mellitus type 1 in Baden-Wuerttemberg, Germany. J Pediatric Endocrinol Metab 2000;13:1081–5.10.1515/JPEM.2000.13.8.1081Search in Google Scholar

10. Willis JA, Scott RS, Darlow BA, Lewy H, Ashkenazi I, et al. Seasonality of birth and onset of clinical disease in children and adolescents (0–19 years) with type 1 diabetes mellitus in Canterbury, New Zealand. J Pediatr Endocrinol Metab 2002;15:645–7.10.1515/JPEM.2002.15.5.645Search in Google Scholar

11. Lévy-Marchal C, Patterson C, Green A. Variation by age group and seasonality at diagnosis of childhood IDDM in Europe. The EURODIAB ACE Study Group. Diabetologia 1995;38:823–30.10.1007/s001250050359Search in Google Scholar PubMed

12. Moltchanova EV, Schreier N, Lammi N, Karvonen M. Seasonal variation of diagnosis of type 1 diabetes mellitus in children worldwide. Diabet Med J Br Diabet Assoc 2009;26:673–8.10.1111/j.1464-5491.2009.02743.xSearch in Google Scholar PubMed

13. Svensson J, Lyngaae-Jørgensen A, Carstensen B, Simonsen LB, Mortensen HB. Danish Childhood Diabetes Registry. Long-term trends in the incidence of type 1 diabetes in Denmark: the seasonal variation changes over time. Pediatr Diabetes 2009;10:248–54.10.1111/j.1399-5448.2008.00483.xSearch in Google Scholar PubMed

14. Schober E, Rami B, Waldhoer T; Austrian Diabetes Incidence Study Group. Steep increase of incidence of childhood diabetes since 1999 in Austria. Time trend analysis 1979–2005. A nationwide study. Eur J Pediatr 2008;167:293–7.10.1007/s00431-007-0480-5Search in Google Scholar PubMed

15. Padaiga Z, Tuomilehto J, Karvonen M, Dahlquist G, Podar T, et al. Seasonal variation in the incidence of type 1 diabetes mellitus during 1983 to 1992 in the countries around the Baltic Sea. Diabet Med J Br Diabet Assoc 1999;16:736–43.10.1046/j.1464-5491.1999.00140.xSearch in Google Scholar PubMed

16. Douglas S, McSporran B, Smail P. Seasonality of presentation of type I diabetes mellitus in children. Scottish Study Group for the Care of Young Diabetics. Scott Med J 1999;44:41–6.10.1177/003693309904400205Search in Google Scholar PubMed

17. Michalková DM, Cernay J, Danková A, Rusnák M, Fandáková K. Incidence and prevalence of childhood diabetes in Slovakia (1985–1992). Slovak Childhood Diabetes Epidemiology Study Group. Diabetes Care 1995;18:315–20.10.2337/diacare.18.3.315Search in Google Scholar PubMed

18. Kalliora MI, Vazeou A, Delis D, Bozas E, Thymelli I, et al. Seasonal variation of type 1 diabetes mellitus diagnosis in Greek children. Horm Athens Greece 2011;10:67–71.10.14310/horm.2002.1294Search in Google Scholar PubMed

19. Ye J, Chen RG, Ashkenazi I, Laron Z. Lack of seasonality in the month of onset of childhood IDDM (0.7–15 years) in Shanghai, China. J Pediatr Endocrinol Metab 1998;11:461–4.10.1515/JPEM.1998.11.3.461Search in Google Scholar PubMed

20. Patterson C, Gyürüs E, Rosenbauer J, Cinek O, Neu A, et al. Seasonal variation in month of diagnosis in children with type 1 diabetes registered in 23 European centers during 1989–2008: little short-term influence of sunshine hours or average temperature. Pediatr Diabetes 2015;16:573–80.10.1111/pedi.12227Search in Google Scholar PubMed

21. Spaans EA, Gusdorf LM, Groenier KH, Brand PL, Veeze HJ, et al. The incidence of type 1 diabetes is still increasing in The Netherlands, but has stabilised in children under five (Young DUDEs-1). Acta Paediatr 2015;104:626–9.10.1111/apa.12949Search in Google Scholar PubMed

22. Struijs JN, Mohnen SM, Molema CCM, de Jong-van Til JT, Baan CA. Effects of bundled payment on curative health care costs in the Netherlands. http://www.rivm.nl/bibliotheek/rapporten/260013001.pdf.Search in Google Scholar

23. The Government of the Netherlands. The citizen service number (BSN). http://www.government.nl/issues/identification-documents/the-citizen-service-number.Search in Google Scholar

24. Rosenbauer J, Herzig P, von Kries R, Neu A, Giani G. Temporal, seasonal, and geographical incidence patterns of type I diabetes mellitus in children under 5 years of age in Germany. Diabetologia 1999;42:1055–9.10.1007/s001250051270Search in Google Scholar PubMed

25. Green J, Casabonne D, Newton R. Coxsackie B virus serology and type 1 diabetes mellitus: a systematic review of published case-control studies. Diabet Med J Br Diabet Assoc 2004;21:507–514.10.1111/j.1464-5491.2004.01182.xSearch in Google Scholar PubMed

26. Oikarinen S, Tauriainen S, Hober D, Lucas B, Vazeou A, et al. Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes. Diabetes 2014;63:655–62.10.2337/db13-0620Search in Google Scholar PubMed

27. Afoke A, Ludvigsson J, Hed J, Lindblom B. Raised IgG and IgM in “epidemic” IDDM suggest that infections are responsible for the seasonality of type I diabetes. Diabetes Res Edinb Scotl 1991;16:11–7.Search in Google Scholar

28. Sloka S, Grant M, Newhook LA. The geospatial relation between UV solar radiation and type 1 diabetes in Newfoundland. Acta Diabetol 2010;47:73–8.10.1007/s00592-009-0100-0Search in Google Scholar PubMed

29. Hyppönen E. Vitamin D and increasing incidence of type 1 diabetes-evidence for an association? Diabetes Obes Metab 2010;12:737–43.10.1111/j.1463-1326.2010.01211.xSearch in Google Scholar PubMed

30. Borkar VV, Devidayal null, Verma S, Bhalla AK. Low levels of vitamin D in North Indian children with newly diagnosed type 1 diabetes. Pediatr Diabetes 2010;11:5–50.10.1111/j.1399-5448.2009.00589.xSearch in Google Scholar PubMed

31. Thorsen SU, Mortensen HB, Carstensen B, Fenger M, Thuesen BH, et al. No difference in vitamin D levels between children newly diagnosed with type 1 diabetes and their healthy siblings: a 13-year nationwide Danish study. Diabetes Care 2013;36:e157–8.10.2337/dc13-0342Search in Google Scholar PubMed PubMed Central

32. Wiegering V, Kaiser J, Tappe D, Weißbrich B, Morbach H, et al. Gastroenteritis in childhood: a retrospective study of 650 hospitalized pediatric patients. Int J Infect Diseases 2011;15:e401–7.10.1016/j.ijid.2011.02.006Search in Google Scholar PubMed


Supplemental Material:

The online version of this article (DOI: 10.1515/jpem-2015-0435) offers supplementary material, available to authorized users.


Received: 2015-11-5
Accepted: 2016-1-18
Published Online: 2016-3-23
Published in Print: 2016-6-1

©2016 by De Gruyter

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