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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma

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Volume 29, Issue 7


Children with severe Osteogenesis imperfecta and short stature present on average with normal IGF-I and IGFBP-3 levels

Heike Hoyer-Kuhn / Laura Höbing / Julia Cassens / Eckhard Schoenau / Oliver Semler
Published Online: 2016-04-18 | DOI: https://doi.org/10.1515/jpem-2015-0385


Background: Osteogenesis imperfecta (OI) is characterized by bone fragility and short stature. Data about IGF-I/IGFBP-3 levels are rare in OI. Therefore IGF-I/IGFBP-3 levels in children with different types of OI were investigated.

Methods: IGF-I and IGFBP-3 levels of 60 children (male n=38) were assessed in a retrospective cross-sectional setting.

Results: Height/weight was significant different [height z-score type 3 versus type 4: p=0.0011 and weight (p≤0.0001)] between OI type 3 and 4. Mean IGF-I levels were in the lower normal range (mean±SD level 137.4±109.1 μg/L). Mean IGFBP-3 measurements were in the normal range (mean±SD 3.105±1.175 mg/L). No significant differences between OI type 3 and 4 children have been observed (IGF-I: p=0.0906; IGFBP-3: p=0.2042).

Conclusions: Patients with different severities of OI have IGF-I and IGFBP-3 levels in the lower normal range. The type of OI does not significantly influence these growth factors.

Keywords: IGF-I; Osteogenesis imperfecta; short stature; srowth hormone


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About the article

Corresponding author: Priv.-Doz. Dr. med. Oliver Semler, Children’s Hospital, University of Cologne, Kerpenerstr. 62, 50937 Cologne, Germany, Phone: +49-221-478-84755, Fax: +49-221-478-1422311

Received: 2015-09-25

Accepted: 2016-03-07

Published Online: 2016-04-18

Published in Print: 2016-07-01

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. The corresponding author confirms that he had full access to all the data in the study and had final responsibility for the decision to submit for publication.

Research funding: We thank “Deutsche Gesellschaft für Osteogenesis imperfecta (Glasknochen) Betroffene e.v.” including “Stiftung Baden-Württemberg” for financial research support.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 7, Pages 813–818, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2015-0385.

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