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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma

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Volume 29, Issue 7


Relationship between HOMA-IR and serum vitamin D in Chinese children and adolescents

Lingli Wang
  • Unit of Laboratory Medicine, Second Hospital Affiliated to Wenzhou Medical University, Wenzhou, P.R. China
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/ Huiyan Wang
  • Unit of Laboratory Medicine, Second Hospital Affiliated to Wenzhou Medical University, Wenzhou, P.R. China
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/ Huaikai Wen
  • Unit of Laboratory Medicine, Second Hospital Affiliated to Wenzhou Medical University, Wenzhou, P.R. China
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/ Hongqun Tao
  • Unit of Laboratory Medicine, Second Hospital Affiliated to Wenzhou Medical University, Wenzhou, P.R. China
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/ Xiaowei Zhao
  • Corresponding author
  • College of Life and Environmental Science, Wenzhou University, 325035 Wenzhou, P.R. China, Fax: +86-577-86597000
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Published Online: 2016-04-18 | DOI: https://doi.org/10.1515/jpem-2015-0422


Background: The objective of this study was to examine the cross-sectional relationship between homeostasis model assessment for insulin resistance (HOMA-IR) and serum 25-hydroxyvitamin D (25-OHD) level in Chinese children and adolescents.

Methods: Anthropometric indices, lipid metabolic profile, and serum levels of glucose, insulin and 25-OHD were determined among 278 healthy prepubertal and pubertal, normal and overweight/obese children and adolescents aged 8–18 years between March 2014 and February 2015.

Results: HOMA-IR was significantly different across vitamin D statuses (p<0.001), even after adjusting for body mass index (BMI) (p=0.035) and waist-to-height ratio (p=0.044); the difference was not significant between the vitamin D deficient and insufficient groups (p=0.120). HOMA-IR negatively correlated with serum 25-OHD level for all subjects (R2=0.148, p<0.001). Furthermore, they negatively correlated in the normal (R2=0.160, p<0.001) and overweight/obese (R2=0.086, p<0.001) groups, respectively. The regression lines of the two groups were parallel (p=0.669) but had a significantly different intercept (p<0.001). An association between HOMA-IR and BMI and serum 25-OHD level (R2=0.654, p<0.001) was demonstrated based on the stepwise multiple linear regression analysis of age, sex, pubertal maturation, BMI, waist-to-height ratio, triglyceride, cholesterol, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), 25-OHD and HOMA-IR.

Conclusions: Our findings supported that lower vitamin D status is strongly associated with worse HOMA-IR.

Keywords: homeostasis model assessment (HOMA); 25-hydroxyvitamin D (25-OHD); insulin resistance (IR)


  • 1.

    Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev 2012;33:456–92.Web of ScienceGoogle Scholar

  • 2.

    Pilz S, Kienreich K, Rutters F, de Jongh R, van Ballegooijen AJ, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diab Rep 2013;13:261–70.Google Scholar

  • 3.

    Lee S, Clark SA, Gill RK, Christakos S. 1,25-Dihydroxyvitamin D3 and pancreatic β-cell function: vitamin D receptors, gene expression, and insulin secretion. Endocrinol 1994;134:1602–10.Google Scholar

  • 4.

    Badawi A, Sayegh S, Sadoun E, Al-Thani M, Arora P, et al. Relationship between insulin resistance and plasma vitamin D in adults. Diabetes Metab Syndr Obes 2014;7:297–303.Google Scholar

  • 5.

    Kayaniyil S, Vieth R, Retnakaran R, Knight JA, Qi Y, et al. Association of vitamin D with insulin resistance and β-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010;33:1379–81.Web of ScienceGoogle Scholar

  • 6.

    Reis JP, von Mühlen D, Miller ER 3rd, Michos ED, Appel LJ. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics 2009;124:e371–9.CrossrefGoogle Scholar

  • 7.

    Alvarez JA, Ashraf A. Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol 2010;2010:351385.Web of ScienceGoogle Scholar

  • 8.

    Eckel RH, Kahn R, Robertson RM, Rizza RA. Preventing cardiovascular disease and diabetes: a call for action from the American Diabetes Association and the American Heart Association. Circulation 2006;113:2943–6.Google Scholar

  • 9.

    Sakou I-I, Psaltopoulou T, Sergentanis TN, Karavanaki K, Karachaliou F, et al. Insulin resistance and cardiometabolic risk factors in obese children and adolescents: a hierarchical approach. J Pediatr Endocrinol Metab 2015;28:589–96.Web of ScienceGoogle Scholar

  • 10.

    Levy-Marchal C, Arslain S, Cutfield W, Sinaiko A, Druet C, et al. Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocr Metab 2010;95:5189–98.Google Scholar

  • 11.

    Group of China Obesity Task Force. The body mass index reference norm for screening overweight and obesity in Chinese children and adolescents. Chin J Epidemiol 2004;25:97–102. (in Chinese).Google Scholar

  • 12.

    Committee to Review Dietary Reference Intakes for Vitamin D and Calcium of Food and Nutrition Board of Institute of Medicine of National Academies. DRI dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press, 2011:13–14.Google Scholar

  • 13.

    Challa AS, Makariou SE, Siomou EC. The relation of vitamin D status with metabolic syndrome in childhood and adolescence: an update. J Pediatr Endocrinol Metab 2015;28:1235–45.Web of ScienceGoogle Scholar

  • 14.

    Rajakumar K, Heras JD, Lee SJ, Holick MF, Arslanian SA. 25-Hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth. Diabetes Care 2012;35:627–33.Web of ScienceGoogle Scholar

  • 15.

    Lee DY, Kwon AR, Ahn JM, Kim YJ, Chae HW, et al. Relationship between serum 25-hydroxyvitamin D concentration and risks of metabolic syndrome in children and adolescents from Korean National Health and Nutrition Examination survey 2008–2010. Ann Pediatr Endocrinol Metab 2015;20:46–52.Google Scholar

  • 16.

    Jorde R, Schirmer H, Wilsgaard T, Joakimsen RM, Mathiesen EB, et al. Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. the Tromsø Study. PLoS One 2012;7:e37295.Web of ScienceGoogle Scholar

  • 17.

    Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, et al. Expression of 25-hydroxyvitamin D3-1α-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 2004; 89–90:121–125.Google Scholar

  • 18.

    Maestro B, Davila N, Carranza MC, Calle C. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol 2003;84:223–30.Google Scholar

  • 19.

    Maestro B, Molero S, Bajo S, D’avila N, Calle C. Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3. Cell Biochem Funct 2002;20:227–32.Google Scholar

  • 20.

    Dunlop TW, Väisänen S, Frank C, Molnár F, Sinkkonen L, et al. The human peroxisome proliferator-activated receptor δ gene is a primary target of 1α,25-dihydroxyvitamin D3 and its nuclear receptor. J Mol Biol 2005;349:248–60.Google Scholar

About the article

Received: 2015-10-25

Accepted: 2016-02-09

Published Online: 2016-04-18

Published in Print: 2016-07-01

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 7, Pages 777–781, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2015-0422.

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