Brunt EM. Pathology of fatty liver disease. Mod Pathol 2007;20:40–8.Google Scholar
Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, et al. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009;58:1538–44.Web of ScienceGoogle Scholar
Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, et al. Prevalence of fatty liver in children and adolescents. Pediatrics 2006;118:1388–93.Google Scholar
Looker AC, Johnson CL, Lacher DA, Pfeiffer CM, Schleicher RL, et al. Vitamin D status: United States, 2001–2006. NCHS Data Brief 2011;59:1–8.Google Scholar
Andıran N, Çelik N, Akça H, Doğan G. Vitamin D deficiency in children and adolescents. J Clin Res Pediatr Endocrinol 2012;4:25–9.Google Scholar
Papandreou D, Rousso I, Mavromichalis I. Update on non-alcoholic fatty liver disease in children. ClinNutr 2007;26:409–15.Google Scholar
Alkhouri N, Carter-Kent C, Elias M, Feldstein AE. Atherogenic dyslipidemia and cardiovascular risk in children with non-alcoholic fatty liver disease. Clin Lipidol 2011;6:305–14.Web of ScienceGoogle Scholar
Della Corte C, Alisi A, Saccari A, De Vito R, Vania A, et al. Non-alcoholic fatty liver in children and adolescents: an overview. J Adolesc Health 2012;51:305–12.Google Scholar
Sanyal AJ, Campbell-Sargeant C, Mirshahi F, Rizzo WB, Contos MJ, et al. Non-alcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001;120:1183–92.Google Scholar
Stephen CH, Tri HL, Stacey MA. Non-alcoholic steatohepatitis. In: Textbook. Schiff’s diseases of liver. 9th ed. Philadelphia, PA: Lippincott William & Wilkins, 2002:1261–89.Google Scholar
Black LJ, Jacoby P, She Ping-Delfos WC, Mori TA, Beilin LJ, et al. Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity. J Gastroenterol Hepatol 2014;29:1215–22.Web of ScienceGoogle Scholar
Yildiz I, Erol OB, Toprak S, Cantez MS, Omer B, et al. Role of vitamin D in children with hepatosteatosis. J Pediatr Gastroenterol Nutr 2014;59:106–11.Google Scholar
Pirgon O, Cekmez F, Bilgin H, Eren E, Dundar B. Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease. Obes Res Clin Pract 2013;7:275–83.Google Scholar
Katz K, Brar PC, Parekh N, Liu YH, Weitzman M. Suspected non-alcoholic Fatty liver disease is not associated with vitamin D status in adolescents after adjustment for obesity. J Obes 2010;2010, 496829.Google Scholar
Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, et al. Body mass index references for Turkish children. Acta Paediatr 2006;95:194–8.Google Scholar
Hatun S. The frequency and state of childhood obesity in Turkey and in the world. Turkish J Pediatr Dis 2012;1:7–14.Google Scholar
Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266–81.Google Scholar
Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:500–3.Google Scholar
Hourigan SK, Abrams S, Yates K, Pfeifer K, Torbenson M, et al. Relation between vitamin D status and non-alcoholic fatty liver disease in children. J Pediatr Gastroenterol Nutr 2015;60: 396–404.Google Scholar
Bril F, Maximos M, Portillo-Sanchez P, Biernacki D, Lomonaco R, et al. Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis. J Hepatol 2015;62:405–11.Google Scholar
Kayaniyil S, Vieth R, Retnakaran R, Knight JA, Qi Y, et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010;33:1379–81.Web of ScienceGoogle Scholar
Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004;79:820–825.Google Scholar
Arunabh S, Pollack S, Yeh J, Aloia JF. Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 2003;88:157–161.Google Scholar
Di Bonito P, Moio N, Scilla C, Cavuto L, Sibilio G, et al. Usefulness of the high triglyceride-to-HDL cholesterol ratio to identify cardiometabolic risk factors and preclinical signs of organ damage in outpatient children. Diabetes Care 2012;35:158–62.Web of ScienceGoogle Scholar
Pacifico L, Cantisani V, Ricci P, Osborn JF, Schiavo E, et al. Non-alcoholic fatty liver disease and carotid atherosclerosis in children. Pediatr Res 2008;63:423–7.Google Scholar
Gokce S, Atbinici Z, Aycan Z, Cınar HG, Zorlu P. The relationship between pediatric non-alcoholic fatty liver disease and cardiovascular risk factors and increased risk of atherosclerosis in obese children. Pediatr Cardiol 2013;34:308–15.Google Scholar
Sert A, Pirgon O, Aypar E, Yilmaz H, Odabas D. Relationship between left ventricular mass and carotid intima media thickness in obese adolescents with non-alcoholic fatty liver disease. J Pediatr Endocrinol Metab 2012;25:927–34.Web of ScienceGoogle Scholar
Gupta R, Bhangoo A, Matthews NA, Anhalt H, Matta Y, et al. The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children. J Pediatr Endocrinol Metab 2011;24:907–11.Web of ScienceGoogle Scholar
Schwimmer JB, Pardee PE, Lavine JE, Blumkin AK, Cook S. Cardiovascular risk factors and the metabolic syndrome in pediatric non-alcoholic fatty liver disease. Circulation 2008;118:277–83.Google Scholar
Cali AM, Zern TL, Taksali SE, de Oliveira AM, Dufour S, et al. Intrahepatic fat accumulation and alterations lipoprotein composition in obese adolescents: a perfect proatherogenic state. Diabetes Care 2007;30:3093–6.Google Scholar
Hernaez R, Lazo M, Bonekamp S, Kamel I, Brancati FL, et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology 2011;54:1082–90.Web of ScienceGoogle Scholar
Hu KC, Wang HY, Liu SC, Liu CC, Hung CL, et al. Non-alcoholic fatty liver disease: Updates in non-invasive diagnosis and correlation with cardiovascular disease. World J Gastroenterol 2014;20:7718–29.Google Scholar
About the article
Published Online: 2016-04-18
Published in Print: 2016-07-01
Author contributions: Oya Balcı Sezer, Derya Bulus, Nesibe Andıran: Substantial contributions to the conception and design; or the acquisition, analysis, or interpretation of the data; Oya Balcı Sezer, Şamil Hızlı: The drafting of the article or critical revision for important intellectual content; Şamil Hızlı, Deniz Yılmaz, Selma Uysal Ramadan: Final approval of the version to be published; Oya Balcı Sezer, Şamil Hızlı, Deniz Yılmaz, Selma Uysal Ramadan, Derya Buluş, Nesibe Andıran: Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the article are appropriately investigated and resolved. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.