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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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2191-0251
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Volume 29, Issue 7

Issues

Low 25-hydroxyvitamin D level is not an independent risk factor for hepatosteatosis in obese children

Oya Balcı Sezer
  • Corresponding author
  • Department of Pediatric Gastroenterology, Kecioren Training and Research Hospital, Ankara, Turkey, Phone: +90 5336915083
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Derya Buluş
  • Department of Pediatric Endocrinology, Kecioren Training and Research Hospital, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Şamil Hızlı
  • Department of Pediatric Gastroenterology, Kecioren Training and Research Hospital, Ankara, Turkey
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  • De Gruyter OnlineGoogle Scholar
/ Nesibe Andıran
  • Department of Pediatric Endocrinology, Kecioren Training and Research Hospital, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Deniz Yılmaz
  • Department of Child Health and Disease, Kecioren Training and Research Hospital, Ankara, Turkey
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Selma Uysal Ramadan
Published Online: 2016-04-18 | DOI: https://doi.org/10.1515/jpem-2015-0426

Abstract

Background: Obesity is an important risk factor for non-alcoholic fatty liver disease. Few studies have evaluated the association between vitamin D and non-alcoholic fatty liver disease in obese children. Therefore, we conducted a study to examine the relationship of vitamin D levels and hepatosteatosis in obese children.

Methods: One hundred and eleven children with obesity participated in this study. Hepatosteatosis was diagnosed and graded using ultrasonography in all patients. Study participants were divided based on the presence of hepatosteatosis into two subgroups (hepatosteatosis and non-hepatosteatosis). Serum levels of 25-hydroxyvitamin D, calcium, phosphate, alkaline phosphatase, parathormone, and lipids were measured and compared.

Results: Hepatosteatosis existed in 52% of obese children without chronic diseases. There was no statistically significant difference in the vitamin D level between the hepatosteatosis and non-hepatosteatosis groups. Alanine aminotransferase levels and the triglycerides-to-high density lipoprotein ratio were significantly higher, and the high density lipoprotein levels were significantly lower in the hepatosteatosis group compared to the non-hepatosteatosis group.

Conclusions: Vitamin D deficiency is not directly related with hepatosteatosis. A high ALT level and a high triglycerides-to-HDL ratio and low HDL levels are more significant in hepatic steatosis in obese children.

Keywords: children; hepatosteatosis; vitamin D

References

  • 1.

    Brunt EM. Pathology of fatty liver disease. Mod Pathol 2007;20:40–8.Google Scholar

  • 2.

    Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, et al. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009;58:1538–44.Web of ScienceGoogle Scholar

  • 3.

    Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, et al. Prevalence of fatty liver in children and adolescents. Pediatrics 2006;118:1388–93.Google Scholar

  • 4.

    Looker AC, Johnson CL, Lacher DA, Pfeiffer CM, Schleicher RL, et al. Vitamin D status: United States, 2001–2006. NCHS Data Brief 2011;59:1–8.Google Scholar

  • 5.

    Andıran N, Çelik N, Akça H, Doğan G. Vitamin D deficiency in children and adolescents. J Clin Res Pediatr Endocrinol 2012;4:25–9.Google Scholar

  • 6.

    Papandreou D, Rousso I, Mavromichalis I. Update on non-alcoholic fatty liver disease in children. ClinNutr 2007;26:409–15.Google Scholar

  • 7.

    Alkhouri N, Carter-Kent C, Elias M, Feldstein AE. Atherogenic dyslipidemia and cardiovascular risk in children with non-alcoholic fatty liver disease. Clin Lipidol 2011;6:305–14.Web of ScienceGoogle Scholar

  • 8.

    Della Corte C, Alisi A, Saccari A, De Vito R, Vania A, et al. Non-alcoholic fatty liver in children and adolescents: an overview. J Adolesc Health 2012;51:305–12.Google Scholar

  • 9.

    Sanyal AJ, Campbell-Sargeant C, Mirshahi F, Rizzo WB, Contos MJ, et al. Non-alcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001;120:1183–92.Google Scholar

  • 10.

    Stephen CH, Tri HL, Stacey MA. Non-alcoholic steatohepatitis. In: Textbook. Schiff’s diseases of liver. 9th ed. Philadelphia, PA: Lippincott William & Wilkins, 2002:1261–89.Google Scholar

  • 11.

    Black LJ, Jacoby P, She Ping-Delfos WC, Mori TA, Beilin LJ, et al. Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity. J Gastroenterol Hepatol 2014;29:1215–22.Web of ScienceGoogle Scholar

  • 12.

    Yildiz I, Erol OB, Toprak S, Cantez MS, Omer B, et al. Role of vitamin D in children with hepatosteatosis. J Pediatr Gastroenterol Nutr 2014;59:106–11.Google Scholar

  • 13.

    Pirgon O, Cekmez F, Bilgin H, Eren E, Dundar B. Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease. Obes Res Clin Pract 2013;7:275–83.Google Scholar

  • 14.

    Katz K, Brar PC, Parekh N, Liu YH, Weitzman M. Suspected non-alcoholic Fatty liver disease is not associated with vitamin D status in adolescents after adjustment for obesity. J Obes 2010;2010, 496829.Google Scholar

  • 15.

    Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, et al. Body mass index references for Turkish children. Acta Paediatr 2006;95:194–8.Google Scholar

  • 16.

    Hatun S. The frequency and state of childhood obesity in Turkey and in the world. Turkish J Pediatr Dis 2012;1:7–14.Google Scholar

  • 17.

    Lakshman R, Elks CE, Ong KK. Childhood obesity. Circulation 2012;126:1770–9.Web of ScienceGoogle Scholar

  • 18.

    Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266–81.Google Scholar

  • 19.

    Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:500–3.Google Scholar

  • 20.

    Hourigan SK, Abrams S, Yates K, Pfeifer K, Torbenson M, et al. Relation between vitamin D status and non-alcoholic fatty liver disease in children. J Pediatr Gastroenterol Nutr 2015;60: 396–404.Google Scholar

  • 21.

    Li L, Zhang L, Pan S, Wu X, Yin X. No significant association between vitamin D and non-alcoholic fatty liver disease in a Chinese population. Dig Dis Sci 2013;58:2376–82.Web of ScienceGoogle Scholar

  • 22.

    Bril F, Maximos M, Portillo-Sanchez P, Biernacki D, Lomonaco R, et al. Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis. J Hepatol 2015;62:405–11.Google Scholar

  • 23.

    Kayaniyil S, Vieth R, Retnakaran R, Knight JA, Qi Y, et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010;33:1379–81.Web of ScienceGoogle Scholar

  • 24.

    Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004;79:820–825.Google Scholar

  • 25.

    Arunabh S, Pollack S, Yeh J, Aloia JF. Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 2003;88:157–161.Google Scholar

  • 26.

    Di Bonito P, Moio N, Scilla C, Cavuto L, Sibilio G, et al. Usefulness of the high triglyceride-to-HDL cholesterol ratio to identify cardiometabolic risk factors and preclinical signs of organ damage in outpatient children. Diabetes Care 2012;35:158–62.Web of ScienceGoogle Scholar

  • 27.

    Pacifico L, Cantisani V, Ricci P, Osborn JF, Schiavo E, et al. Non-alcoholic fatty liver disease and carotid atherosclerosis in children. Pediatr Res 2008;63:423–7.Google Scholar

  • 28.

    Gokce S, Atbinici Z, Aycan Z, Cınar HG, Zorlu P. The relationship between pediatric non-alcoholic fatty liver disease and cardiovascular risk factors and increased risk of atherosclerosis in obese children. Pediatr Cardiol 2013;34:308–15.Google Scholar

  • 29.

    Sert A, Pirgon O, Aypar E, Yilmaz H, Odabas D. Relationship between left ventricular mass and carotid intima media thickness in obese adolescents with non-alcoholic fatty liver disease. J Pediatr Endocrinol Metab 2012;25:927–34.Web of ScienceGoogle Scholar

  • 30.

    Gupta R, Bhangoo A, Matthews NA, Anhalt H, Matta Y, et al. The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children. J Pediatr Endocrinol Metab 2011;24:907–11.Web of ScienceGoogle Scholar

  • 31.

    Schwimmer JB, Pardee PE, Lavine JE, Blumkin AK, Cook S. Cardiovascular risk factors and the metabolic syndrome in pediatric non-alcoholic fatty liver disease. Circulation 2008;118:277–83.Google Scholar

  • 32.

    Cali AM, Zern TL, Taksali SE, de Oliveira AM, Dufour S, et al. Intrahepatic fat accumulation and alterations lipoprotein composition in obese adolescents: a perfect proatherogenic state. Diabetes Care 2007;30:3093–6.Google Scholar

  • 33.

    Hernaez R, Lazo M, Bonekamp S, Kamel I, Brancati FL, et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology 2011;54:1082–90.Web of ScienceGoogle Scholar

  • 34.

    Hu KC, Wang HY, Liu SC, Liu CC, Hung CL, et al. Non-alcoholic fatty liver disease: Updates in non-invasive diagnosis and correlation with cardiovascular disease. World J Gastroenterol 2014;20:7718–29.Google Scholar

About the article

Received: 2015-10-28

Accepted: 2016-02-22

Published Online: 2016-04-18

Published in Print: 2016-07-01


Author contributions: Oya Balcı Sezer, Derya Bulus, Nesibe Andıran: Substantial contributions to the conception and design; or the acquisition, analysis, or interpretation of the data; Oya Balcı Sezer, Şamil Hızlı: The drafting of the article or critical revision for important intellectual content; Şamil Hızlı, Deniz Yılmaz, Selma Uysal Ramadan: Final approval of the version to be published; Oya Balcı Sezer, Şamil Hızlı, Deniz Yılmaz, Selma Uysal Ramadan, Derya Buluş, Nesibe Andıran: Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the article are appropriately investigated and resolved. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 7, Pages 783–788, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2015-0426.

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