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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


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Volume 29, Issue 7

Issues

17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome

Jingwen Hou / Heidi Cook-Andersen / H. Irene Su / Rana Shayya / Kevin H. Maas / Christine M. Burt-Solorzano
  • Department of Pediatrics, Center for Research in Reproduction, University of Virginia Charlottesville, VA, USA
  • Other articles by this author:
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/ Ajay Kumar / R. Jeffrey Chang
Published Online: 2016-05-11 | DOI: https://doi.org/10.1515/jpem-2015-0461

Abstract

Background: In adult women with polycystic ovary syndrome (PCOS) 17-OHP responses to human chorionic gonadotropin (hCG) stimulation are highly variable and inversely correlated with serum anti-Mullerian hormone (AMH) levels. The objective of this study was to determine whether adolescents with PCOS exhibit similar variable 17-OHP responsiveness to hCG and whether these responses are correlated to AMH levels.

Methods: In a prospective study, adolescent PCOS (n=14) and normal controls (n=10) received 25 μg of hCG, intravenously. Blood samples were obtained before and 24 h afterwards for measurement of 17-OHP and basal AMH.

Results: Variable 17-OHP responses to hCG were observed among PCOS girls similar to that observed in adults. There was no correlation between AMH and 17-OHP responses to hCG.

Conclusions: Among adult and adolescent individuals with PCOS variable 17-OHP production appears to be characteristic of the disorder. In adolescent PCOS, 17-OHP responsiveness to hCG is not correlated to AMH.

Keywords: adolescent; anti-Mullerian hormone; 17-hydroxyprogesterone; polycystic ovary syndrome

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About the article

Corresponding author: R. Jeffrey Chang, MD, Department of Reproductive Medicine, University of California, School of Medicine, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0633, USA, Phone: +(858) 534-8930, Fax: +(868) 534-8856


Received: 2015-11-30

Accepted: 2016-03-29

Published Online: 2016-05-11

Published in Print: 2016-07-01


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This research was supported by the Eunice Kennedy Shriver NICHD/NIH through cooperative agreements (U54 HD12303-28 and U54 HD028934) as part of the Specialized Cooperative Centers Program in Reproduction and Infertility Research, K23 HD070854, NIH T32 HD007203, and in part by NIH grant MO1 RR00827. Clinical Trial Registration Number: NCT01154192.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 29, Issue 7, Pages 835–840, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2015-0461.

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