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Licensed Unlicensed Requires Authentication Published by De Gruyter May 11, 2016

17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome

  • Jingwen Hou , Heidi Cook-Andersen , H. Irene Su , Rana Shayya , Kevin H. Maas , Christine M. Burt-Solorzano , Ajay Kumar and R. Jeffrey Chang EMAIL logo

Abstract

Background: In adult women with polycystic ovary syndrome (PCOS) 17-OHP responses to human chorionic gonadotropin (hCG) stimulation are highly variable and inversely correlated with serum anti-Mullerian hormone (AMH) levels. The objective of this study was to determine whether adolescents with PCOS exhibit similar variable 17-OHP responsiveness to hCG and whether these responses are correlated to AMH levels.

Methods: In a prospective study, adolescent PCOS (n=14) and normal controls (n=10) received 25 μg of hCG, intravenously. Blood samples were obtained before and 24 h afterwards for measurement of 17-OHP and basal AMH.

Results: Variable 17-OHP responses to hCG were observed among PCOS girls similar to that observed in adults. There was no correlation between AMH and 17-OHP responses to hCG.

Conclusions: Among adult and adolescent individuals with PCOS variable 17-OHP production appears to be characteristic of the disorder. In adolescent PCOS, 17-OHP responsiveness to hCG is not correlated to AMH.


Corresponding author: R. Jeffrey Chang, MD, Department of Reproductive Medicine, University of California, School of Medicine, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0633, USA, Phone: +(858) 534-8930, Fax: +(868) 534-8856

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This research was supported by the Eunice Kennedy Shriver NICHD/NIH through cooperative agreements (U54 HD12303-28 and U54 HD028934) as part of the Specialized Cooperative Centers Program in Reproduction and Infertility Research, K23 HD070854, NIH T32 HD007203, and in part by NIH grant MO1 RR00827. Clinical Trial Registration Number: NCT01154192.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2015-11-30
Accepted: 2016-3-29
Published Online: 2016-5-11
Published in Print: 2016-7-1

©2016 by De Gruyter

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