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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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2191-0251
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Volume 30, Issue 1

Issues

Nocturnal levels of chemerin and progranulin in adolescents: influence of sex, body mass index, glucose metabolism and sleep

Johann Daxer
  • Department of Women and Child Health and Center for Pediatric Research, Leipzig University, Leipzig, Germany
  • Department of Internal Medicine, Hospital Nürtingen, Nürtingen, Germany
  • Other articles by this author:
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/ Theresa Herttrich
  • Department of Women and Child Health and Center for Pediatric Research, Leipzig University, Leipzig, Germany
  • Department of Internal Medicine, Klinikum Dritter Order, Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ying Y. Zhao
  • Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
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/ Mandy Vogel / Andreas Hiemisch
  • Department of Women and Child Health and Center for Pediatric Research, Leipzig University, Leipzig, Germany
  • LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany
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/ Kathrin Scheuermann
  • Department of Women and Child Health and Center for Pediatric Research, Leipzig University, Leipzig, Germany
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/ Antje Körner
  • Department of Women and Child Health and Center for Pediatric Research, Leipzig University, Leipzig, Germany
  • LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany
  • IFB Adiposity Diseases, Leipzig University, Leipzig, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Jürgen Kratzsch / Wieland Kiess
  • Department of Women and Child Health and Center for Pediatric Research, Leipzig University, Leipzig, Germany
  • LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany
  • IFB Adiposity Diseases, Leipzig University, Leipzig, Germany
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/ Mirja Quante
  • Corresponding author
  • Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
  • IFB Adiposity Diseases, Leipzig University, Leipzig, Germany
  • Department of Neonatology, University of Tuebingen, Calwerstr. 7, 72076 Tuebingen, Germany
  • Email
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Published Online: 2016-12-10 | DOI: https://doi.org/10.1515/jpem-2016-0378

Abstract

Background:

Adipokines have been implicated in obesity, insulin resistance and sleep regulation. However, the role of chemerin and progranulin, two recently described adipokines, in the context of sleep remains unclear. The aim of this study was to compare nocturnal serum chemerin and progranulin levels between overweight/obese and normal-weight adolescents and to assess variations by sex, across different sleep stages and in relation to glucose metabolism.

Methods:

The study sample included 34 overweight/obese and 32 normal-weight adolescents from secondary schools and the Leipzig Research Center for Civilization Diseases (LIFE) Child study cohort. We obtained longitudinal serum adipokine levels during in-laboratory polysomnography followed by an oral glucose tolerance test.

Results:

Overweight/obese adolescents had significantly higher mean nocturnal serum chemerin area under the curve (AUC) levels (348.2±133.3 vs. 241.7±67.7 vs. ng/mL×h, p<0.001) compared to normal-weight controls. In detail, higher chemerin AUC levels in obese/overweight subjects were exclusively due to increased levels in females. No overall difference for serum progranulin AUC was found between the groups. However, when assessing sex-specific levels, serum progranulin AUC levels were ~30% higher in overweight/obese males compared to overweight/obese females. Of note, nocturnal serum chemerin and progranulin AUC did not exhibit a correlation with markers of glucose metabolism or sleep stages.

Conclusions:

Collectively, we report a sexual dimorphism in nocturnal progranulin and chemerin levels, which may help explain underlying differences in energy balance and body composition between males and females in the context of obesity.

Keywords: adipokines; adolescents; obesity

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About the article

Corresponding author: Mirja Quante, MD, Department of Neonatology, University of Tuebingen, Calwerstr. 7, 72076 Tuebingen, Germany, Phone: +49-7071-80877; Fax: +49-7071-4356

aJohann Daxer and Theresa Herttricha contributed equally to this work.


Received: 2016-09-26

Accepted: 2016-10-09

Published Online: 2016-12-10

Published in Print: 2017-01-01


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This work was supported by the German Diabetes Association and by the German Federal Ministry of Education and Research (IFB and Competence Network Adiposity). LIFE is funded by the European Union, by the European Regional Development Fund and by means of the Free State of Saxony within the framework of the excellence initiative.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 30, Issue 1, Pages 57–61, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2016-0378.

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