Isaksson OG, Jansson JO, Gause IA. Growth hormone stimulates longitudinal bone growth directly. Science 1982;216:1237–9.Google Scholar
Isgaard J, Nilsson A, Lindahl A, Jansson JO, Isaksson OG. Effects of local administration of GH and IGF-1 on longitudinal bone growth in rats. Am J Physiol 1986;250:E367–72.Google Scholar
Davidson MB. Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev 1987;8:115–31.Google Scholar
Kim SO, Loesch K, Wang X, Jiang J, Mei L, et al. A Role for Grb2-associated binder-1 in growth hormone signaling. Endocrinology 2002;143:4856–67.Google Scholar
Smit LS, Meyer DJ, Billestrup N, Norstedt G, Schwartz J, et al. The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH. Mol Endocrinol 1996;10:519–33.Google Scholar
Kim SO, Jiang J, Yi W, Fengi GS, Frank SJ. Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signalling. J Biol Chem 1998;4:2344–54.Google Scholar
Yoshimura A. The CIS family. Negative regulators of JAK-STAT signaling. Cytokine Growth Factor Rev 1998;9:197–204.Google Scholar
Leung DW, Spencer SA, Cachlanes G, Hammonds RG, Collins C, et al. Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 1987;330:537–43.Google Scholar
Strous GJ, van Kerkhof P, Govers R, Ciechanover A, Schwartz AL. The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J 1996;15:3806–12.Google Scholar
Landsman T, Waxman DJ. Role of the cytokine-induced SH2-containing protein CIS in growth hormone receptor internalization. J Biol Chem 2005;280:37471–80.Google Scholar
Yamauchi T, Ueki K, Tobe K, Tamemoto H, Sekine N, et al. Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature 1997;390:91–6.Google Scholar
Kim SO, Houtman JC, Jiang J, Ruppert JM, Bertics PJ, et al. Growth hormone-induced alteration in ErbB-2 phosphorylation status in 3T3–F442A fibroblasts. J Biol Chem 1999;274:36015–24.Google Scholar
Huang Y, Kim SO, Jiang J, Frank SJ. Growth hormone-induced phosphorylation of EGF receptor in 3T3–F442A cells: modulation of EGF-induced trafficking and signaling. J Biol Chem 2003;278:18902–13.Google Scholar
Kofoed EM, Hwa V, Little B, Woods KA, Buckway CK, et al. Growth hormone insensitivity associated with a STAT5b mutation. N Engl J Med 2003;349:1139–47.Google Scholar
Hwa V, Haeusler G, Pratt KL, Little BM, Frisch H, et al. Total absence of functional acid labile subunit, resulting in severe insulin-like growth factor deficiency and moderate growth failure. J Clin Endocrinol Metab 2006;91:1826–31.Google Scholar
Woods KA, Camacho-Hübner C, Savage MO, Clark AJ. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med 1996;335:1363–7.Google Scholar
Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, et al. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. N Engl J Med 2003;349:2211–22.Google Scholar
Ranke MB, Savage MO, Chatelain PG, Preece MA, Rosenfeld RG, et al. Long-term treatment of growth hormone insensitivity syndrome with IGF-I. Results of the European Multicentre Study. The Working Group on Growth Hormone Insensitivity Syndromes. Horm Res 1999;51:128–34.Google Scholar
Rojas-Gil AP, Ziros PG, Diaz L, Kletsas D, Basdra EK, et al. Growth hormone/JAK-STAT axis signal-transduction defect. FEBS J 2006;273:3454–66.Google Scholar
Rojas Gil AP, Kostopoulou E, Karageorgou I, Kamzelas K, Spiliotis BE. Increased growth hormone receptor (GHR) degradation due to over-expression of cytokine inducible SH2 domain-containing protein (CIS) as a cause of GH transduction defect (GHTD). J Pediatr Endocr Met 2012;25:897–908.Google Scholar
Henson ES, Gibson SB. Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy. Cell Signal 2006;18:2089–97.Google Scholar
Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, et al. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 2006;366:2–16.Google Scholar
Ram PA, Waxman DJ. Role of the Cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone. J Biol Chem 2000;275:39487–96.Google Scholar
Kario E, Marmor MD, Adamsky K, Citri A, Amit I, et al. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. JBC 2005;280:7038–48.Google Scholar
Tonko-Geymayer S, Goupille O, Tonko M, Soratrol C, Yoshimura A, et al. Regulation and function of the cytokine-inducible SH-2 domain proteins, CIS and SOCS3, in mammary epithelial cells. Mol Endocrinol 2002;16:1680–95.Google Scholar
About the article
Published Online: 2017-01-18
Published in Print: 2017-02-01
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.