Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362–74.Google Scholar
Ogden CL, Carroll MD, Flegal KM. High body mass index for age among US children and adolescents, 2003–2006. J Am Med Assoc 2008;299:2401–5.Google Scholar
Ahluwalia N, Dalmasso P, Rasmussen M, Lipsky L, Currie C, et al. Trends in overweight prevalence among 11-, 13- and 15-year-olds in 25 countries in Europe, Canada and USA from 2002 to 2010. Eur J Public Health 2015;25(Suppl 2):28–32.Google Scholar
Chiarelli F, Marcovecchio ML. Insulin resistance and obesity in childhood. Eur J Endocrinol 2008;159(Suppl 1):S67–74.Google Scholar
Cruz ML, Shaibi GQ, Weigensberg MJ, Spruijt-Metz D, Ball GD, et al. Pediatric obesity and insulin resistance: chronic disease risk and implications for treatment and prevention beyond body weight modification. Annu Rev Nutr 2005;25:435–68.Google Scholar
Lee JM. Insulin resistance in children and adolescents. Rev Endocr Metab Disord 2006;7:141–7.Google Scholar
Pankow JS, Jacobs DR Jr, Steinberger J, Moran A, Sinaiko AR. Insulin resistance and cardiovascular disease risk factors in children of parents with the insulin resistance (metabolic) syndrome. Diabetes Care 2004;27:775–80.Google Scholar
Allan CL, Flett B, Dean HJ. Quality of life in First Nation youth with type 2 diabetes. Matern Child Health J 2008;12(Suppl 1):103–9.Google Scholar
Hood KK, Beavers DP, Yi-Frazier J, Bell R, Dabelea D, et al. Psychosocial burden and glycemic control during the first 6 years of diabetes: results from the SEARCH for Diabetes in Youth study. J Adolesc Health 2014;55:498–504.Google Scholar
Icks A, Rosenbauer J, Rathmann W, Haastert B, Gandjour A, et al. Direct costs of care in Germany for children and adolescents with diabetes mellitus in the early course after onset. J Pediatr Endocrinol Metab 2004;17:1551–9.Google Scholar
Wang G, Dietz WH. Economic burden of obesity in youths aged 6 to 17 years: 1979–1999. Pediatrics 2002;109:E81–1.Google Scholar
Schwartz B, Jacobs DR Jr, Moran A, Steinberger J, Hong CP, et al. Measurement of insulin sensitivity in children: comparison between the euglycemic-hyperinsulinemic clamp and surrogate measures. Diabetes Care 2008;31:783–8.Google Scholar
Brown RJ, Yanovski JA. Estimation of insulin sensitivity in children: methods, measures and controversies. Pediatr Diabetes 2014;15:151–61.Google Scholar
Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000;85:2402–10.Google Scholar
Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ. A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 2001;24:539–48.Google Scholar
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412–9.Google Scholar
Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462–70.Google Scholar
van der Aa MP, Fazeli Farsani S, Knibbe CA, de Boer A, van der Vorst MM. Population-based studies on the epidemiology of insulin resistance in children. J Diabetes Res 2015;2015:362375.Google Scholar
Patarrão RS, Wayne Lautt W, Paula Macedo M. Assessment of methods and indexes of insulin sensitivity. Rev Port Endocrinol Diabetes Metabol 2014;9:65–73.Google Scholar
Rossner SM, Neovius M, Mattsson A, Marcus C, Norgren S. HOMA-IR and QUICKI: decide on a general standard instead of making further comparisons. Acta Paediatr 2010;99:1735–40.Google Scholar
van der Aa MP, Fazeli Farsani S, Kromwijk LA, de Boer A, Knibbe CA, et al. How to screen obese children at risk for type 2 diabetes mellitus? Clin Pediatr (Phila) 2014;53:337–42.Google Scholar
Ten S, Bhangoo A, Ramchandani N, Mueller C, Vogiatzi M, et al. Characterization of insulin resistance syndrome in children and young adults. When to screen for prediabetes? J Pediatr Endocrinol Metab 2007;20:989–99.Google Scholar
Conwell LS, Trost SG, Brown WJ, Batch JA. Indexes of insulin resistance and secretion in obese children and adolescents: a validation study. Diabetes Care 2004;27:314–9.Google Scholar
Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:e500–3.Google Scholar
Uwaifo GI, Fallon EM, Chin J, Elberg J, Parikh SJ, et al. Indices of insulin action, disposal, and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children. Diabetes Care 2002;25:2081–7.Google Scholar
Henriquez S, Jara N, Bunout D, Hirsch S, de la Maza MP, et al. Variability of formulas to assess insulin sensitivity and their association with the Matsuda index. Nutr Hosp 2013;28:1594–8.Google Scholar
Antuna-Puente B, Faraj M, Karelis AD, Garrel D, Prud’homme D, et al. HOMA or QUICKI: is it useful to test the reproducibility of formulas? Diabetes Metab 2008;34:294–6.Google Scholar
Shah S, Kublaoui BM, Oden JD, White PC. Screening for type 2 diabetes in obese youth. Pediatrics 2009;124:573–9.Google Scholar
Brar PC, Mengwall L, Franklin BH, Fierman AH. Screening obese children and adolescents for prediabetes and/or type 2 diabetes in pediatric practices: a validation study. Clin Pediatr (Phila) 2014;53:771–6.Google Scholar
Allard P, Delvin EE, Paradis G, Hanley JA, O’Loughlin J, et al. Distribution of fasting plasma insulin, free fatty acids, and glucose concentrations and of homeostasis model assessment of insulin resistance in a representative sample of Quebec children and adolescents. Clin Chem 2003;49:644–9.Google Scholar
d’Annunzio G, Vanelli M, Pistorio A, Minuto N, Bergamino L, et al. Insulin resistance and secretion indexes in healthy Italian children and adolescents: a multicentre study. Acta Biomed 2009;80:21–8.Google Scholar
American Diabetes Association. 2. Classification and Diagnosis of Diabetes. Diabetes Care 2016;39(Suppl 1):S13–22.Google Scholar
Jones AG, Hattersley AT. The clinical utility of C-peptide measurement in the care of patients with diabetes. Diabet Med 2013;30:803–17.Google Scholar
About the article
Published Online: 2016-12-16
Published in Print: 2017-02-01
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. M.A. performed the literature review and data analysis and wrote a first version of the manuscript. All authors discussed study design, data, and interpreted the results. C.K., A.B., and M.V. reviewed and edited the manuscript. All authors take full responsibility for the contents of the manuscript, M.V. is the guarantor of this work.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.