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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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2191-0251
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Volume 30, Issue 2 (Feb 2017)

Issues

High predictability of impaired glucose tolerance by combining cardiometabolic screening parameters in obese children

Cornelis Jan de Groot
  • Corresponding author
  • Willem-Alexander Children’s Hospital, Leiden University Medical Center, PO box 9600, 2333 ZA, Leiden, The Netherlands, Phone: +31 70 526 2824
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jeroen van der Grond / Yosine Delgado
  • Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Edmond H.H.M. Rings
  • Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands
  • Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sabine E. Hannema
  • Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, The Netherlands
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Erica L.T. van den Akker
Published Online: 2017-01-11 | DOI: https://doi.org/10.1515/jpem-2016-0289

Abstract

Background:

There is debate on which overweight and obese children should be screened for the presence of impaired glucose tolerance (IGT) by oral glucose tolerance testing (OGTT). The objective of the study was to identify risk factors predictive of the presence of IGT.

Methods:

In a cohort of overweight children, who underwent OGTT, we determined the association of anthropometric and laboratory parameters with IGT and whether combining parameters improved the sensitivity of screening for IGT.

Results:

Out of 145 patients, IGT was present in 11, of whom two had impaired fasting glucose (IFG). Elevated blood pressure (p=0.025) and elevated liver enzymes (p=0.003) were associated with IGT, whereas IFG was not (p=0.067), screening patients with either one of these parameters predicted IGT with a high sensitivity of 1.00, and a number needed to screen of 5.7.

Conclusions:

Screening all patients with either IFG, presence of elevated blood pressure and elevated liver enzymes, significantly increases predictability of IGT compared to using IFG alone.

Keywords: glucose abnormalities; impaired fasting glucose; impaired glucose tolerance; liver enzymes; oral glucose tolerance test

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About the article

Received: 2016-07-19

Accepted: 2016-11-21

Published Online: 2017-01-11

Published in Print: 2017-02-01


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. Corjan de Groot: Drs. de Groot conceptualized and designed the study, collected and analyzed the data and drafted the initial manuscript. Jeroen van der Grond: Dr. van der Grond provided extensive support in data analysis, edited the initial manuscript and critically reviewed the final manuscript. Yosine Delgado: Ms. Delgado collected the data, was involved in analyzing the data and critically reviewed the final manuscript. Edmond Rings: Prof. dr. Rings supervised the project and critically reviewed the final manuscript. Sabine Hannema: Dr. Hannema had valuable input on the design of the study and analysis of the data and critically reviewed the final version of the manuscript. Erica van den Akker: Dr. van den Akker had valuable input on the design of the study, the analysis of data, editing of the initial manuscript and critically reviewed the final version of the manuscript.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2016-0289.

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