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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

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2191-0251
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Volume 30, Issue 4

Issues

Vitamin D supplementation, the metabolic syndrome and oxidative stress in obese children

Tal Grunwald
  • Department of Pediatrics, Section of Endocrinology and Diabetes, St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA
  • Other articles by this author:
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/ Shruti Fadia
  • Department of Pediatrics, Section of Endocrinology and Diabetes, St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA
  • Currently affiliated with Memorial Children’s Hospital, South Bend, IN, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bruce Bernstein
  • Department of Pediatrics, Section of General Pediatrics, St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Matthew Naliborski
  • Department of Pediatrics, Section of Endocrinology and Diabetes, St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Shufang Wu
  • Department of Pediatrics, Section of Endocrinology and Diabetes, St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA
  • Center for Translational Medicine, The First affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, P. R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Francesco De Luca
  • Corresponding author
  • Department of Pediatrics, Section of Endocrinology and Diabetes, St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2016-12-15 | DOI: https://doi.org/10.1515/jpem-2016-0211

Abstract

Background:

Previous studies suggest that vitamin D may play a role in cardiovascular and metabolic health. Oxidative stress has also been implicated in the development of cardiovascular disease. Evidence suggests that vitamin D deficiency may contribute to the occurrence of oxidative stress. This study aimed to determine whether treatment and correction of vitamin D deficiency in obese children led to changes in their metabolic profile, independent of changes in adiposity. In addition, we aimed to determine whether vitamin D deficiency and oxidative stress are causally related in obese children.

Methods:

In the retrospective arm, chart review identified 32 obese children who experienced normalization of vitamin D deficiency or insufficiency with vitamin D supplementation. We then correlated laboratory and anthropometric data with vitamin D levels. In the prospective arm of the study, urinary 8-isoprostane and hydrogen peroxide were measured before and after correction of vitamin D deficiency/insufficiency and correlated to vitamin D levels in seven patients.

Results:

In our predominantly Hispanic population of obese children in an urban setting, we demonstrated a cause-effect relationship between vitamin D deficiency and oxidative stress. In contrast, we found no association between vitamin D status, adiposity, and markers of insulin sensitivity, nor any effect of vitamin D treatment on the same parameters.

Conclusions:

These discordant findings suggest a differential effect of vitamin D on cardiovascular risk factors such as oxidative stress and insulin resistance. To confirm these findings, further prospective studies with larger sample size and longer follow-up are warranted.

Keywords: metabolism; obesity; vitamin D

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About the article

Corresponding author: Francesco De Luca, MD, Department of Pediatrics, Section of Endocrinology and Diabetes, St. Christopher’s Hospital for Children, 160 East Erie Avenue, Philadelphia, PA 19134, USA, Phone: 215-427-8101, Fax: 215-427-8105


Received: 2016-05-26

Accepted: 2016-11-04

Published Online: 2016-12-15

Published in Print: 2017-04-01


Author contributions: All the authors have accepted responsibility for the entire content of this submitted article and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 30, Issue 4, Pages 383–388, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2016-0211.

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