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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Ogata, Tsutomu / Toppari, Jorma

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IMPACT FACTOR 2017: 1.086

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2191-0251
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Volume 30, Issue 4

Issues

Increase of body mass index (BMI) from 1.5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age

Osamu Arisaka
  • Corresponding author
  • Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi-ken, 321-0293 Japan, Phone: +71-282-86-1111, Fax: +71-282-86-7521
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/ Toshimi Sairenchi / Go Ichikawa / Satomi Koyama
Published Online: 2017-03-15 | DOI: https://doi.org/10.1515/jpem-2016-0227

Abstract:

To elucidate the effect of early growth patterns on the metabolic sensitivity to adiposity, we examined the relationship between the homeostatic model assessment of insulin resistance (HOMA-IR) and body mass index (BMI) levels at 12 years of age in 101 boys and 91 girls in a birth cohort. Children with an increase in BMI from the ages of 1.5 to 3 years exhibited a greater increase of HOMA-IR per BMI increase at 12 years of age compared to those with a decrease in BMI or stable BMI from 1.5 to 3 years. This suggests that children who show an increase in BMI from 1.5 to 3 years, a period normally characterized by a decreased or stable BMI, are more prone to developing insulin resistance at 12 years of age.

Keywords:: adiposity rebound; BMI; insulin resistance; metabolic sensitivity; toddler

References

  • 1.

    Sinaiko AR, Caprio S. Insulin resistance. J Pediatr 2012;161:11–5.Google Scholar

  • 2.

    Prince RL, Kuk JL, Ambler KA, Dhaliwal J, Ball GD. Predictors of metabolically healthy obesity in children. Diabetes Care 2014;37:1462–8.Google Scholar

  • 3.

    Nightingale CM, Rudnicka AR, Owen CG, Wells JC, Sattar N, et al. Influence of adiposity on insulin resistance and glycemia markers among U.K. Children of South Asian, black African-Caribbean, and white European origin: child heart and health study in England. Diabetes Care 2013;36:1712–9.Google Scholar

  • 4.

    Gao H, Salim A, Lee J, Tai ES, van Dam RM. Can body fat distribution, adiponectin levels and inflammation explain differences in insulin resistance between ethnic Chinese, Malays and Asian Indians? Int J Obes (Lond) 2012;36:1086–93.Google Scholar

  • 5.

    Fomon SJ, Haschke F, Ziegler EE, Nelson SE. Body composition of reference children from birth to age 10 years. Am J Clin Nutr 1982;35(Suppl 5):1169–75.Google Scholar

  • 6.

    Veldhuis JD, Roemmich JN, Richmond EJ, Rogol AD, Lovejoy JC, et al. Endocrine control of body composition in infancy, childhood, and puberty. Endocr Rev 2005;26:114–46.Google Scholar

  • 7.

    Toro-Ramos T, Paley C, Pi-Sunyer FX, Gallagher D. Body composition during fetal development and infancy through the age of 5 years. Eur J Clin Nutr 2015;69:1279–89.Google Scholar

  • 8.

    Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998;21:2191–2.Google Scholar

  • 9.

    Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:e500–3.Google Scholar

  • 10.

    Thorén A, Werner B, Lundholm C, Bråbäck L, Silfverdal SA. A rapid growth rate in early childhood is a risk factor for becoming overweight in late adolescence. Acta Paediatr 2015;104:1138–43.Google Scholar

  • 11.

    Koyama S, Ichikawa G, Kojima M, Shimura N, Sairenchi T, et al. Adiposity rebound and the development of metabolic syndrome. Pediatrics 2014;133:e114–9.Google Scholar

  • 12.

    Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Mol Cell Endocrinol 2015;402:113–9.Google Scholar

  • 13.

    Djiane J, Attig L. Role of leptin during perinatal metabolic programming and obesity. J Physiol Pharmacol 2008;59(Suppl 1):55–63.Google Scholar

  • 14.

    Boeke CE, Mantzoros CS, Hughes MD, Rifas-Shiman SL, Villamor E, et al. Differential associations of leptin with adiposity across early childhood. Obesity (Silver Spring) 2013;21:1430–7.Google Scholar

  • 15.

    Brito N, Fonseca M, Dinis I, Mirante A. Metabolic factors in obesity. J Pediatr Endocrinol Metab 2010;23:97–100.Google Scholar

  • 16.

    Koyama S, Sairenchi T, Shimura N, Arisaka O. Association between timing of adiposity rebound and body weight gain during infancy. J Pediatr 2015;166:309–12.Google Scholar

  • 17.

    Perng W, Haji H, Berfolt MB, Rifas-Shiman SL, Kramer MS, et al. Birth size early life weight gain, and midchildhood cardiometabolic health. J Pediatr 2016;173:122–30.Google Scholar

  • 18.

    Arisaka O, Ichikawa G, Koyama S, Sairenchi T. Increase in BMI from 1.5 to 3 years of age is a risk for cardiometabolic disease. Jacobs J Obes 2015;1:019.Google Scholar

About the article

Received: 2016-06-06

Accepted: 2017-01-09

Published Online: 2017-03-15

Published in Print: 2017-04-01


Author contributions: Dr. Arisaka designed the study, analyzed and interpreted data, generated the table and drafted the initial manuscript; Dr. Sairenchi analyzed and interpreted data, and reviewed the manuscript; and Drs. Ichikawa and Koyama collected data and reviewed the manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This study was supported by a subsidy to a Grant-in-Aid for Scientific Research from the Ministry of Education, Sports, Science and Technology (Subject number: 22591136, 2010–2013, Study on early intervention of child obesity with a focus on adiposity rebound, Subject number: 25461559, 2013–2016, Exploratory/systematic cohort study to clarify the relationship between weight increase in childhood and obesity/metabolic disorder).

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 30, Issue 4, Pages 455–457, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2016-0227.

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