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Journal of Pediatric Endocrinology and Metabolism

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Volume 30, Issue 4


Increase of body mass index (BMI) from 1.5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age

Osamu Arisaka
  • Corresponding author
  • Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi-ken, 321-0293 Japan, Phone: +71-282-86-1111, Fax: +71-282-86-7521
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  • Other articles by this author:
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/ Toshimi Sairenchi / Go Ichikawa / Satomi Koyama
Published Online: 2017-03-15 | DOI: https://doi.org/10.1515/jpem-2016-0227


To elucidate the effect of early growth patterns on the metabolic sensitivity to adiposity, we examined the relationship between the homeostatic model assessment of insulin resistance (HOMA-IR) and body mass index (BMI) levels at 12 years of age in 101 boys and 91 girls in a birth cohort. Children with an increase in BMI from the ages of 1.5 to 3 years exhibited a greater increase of HOMA-IR per BMI increase at 12 years of age compared to those with a decrease in BMI or stable BMI from 1.5 to 3 years. This suggests that children who show an increase in BMI from 1.5 to 3 years, a period normally characterized by a decreased or stable BMI, are more prone to developing insulin resistance at 12 years of age.

Keywords:: adiposity rebound; BMI; insulin resistance; metabolic sensitivity; toddler


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About the article

Received: 2016-06-06

Accepted: 2017-01-09

Published Online: 2017-03-15

Published in Print: 2017-04-01

Author contributions: Dr. Arisaka designed the study, analyzed and interpreted data, generated the table and drafted the initial manuscript; Dr. Sairenchi analyzed and interpreted data, and reviewed the manuscript; and Drs. Ichikawa and Koyama collected data and reviewed the manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This study was supported by a subsidy to a Grant-in-Aid for Scientific Research from the Ministry of Education, Sports, Science and Technology (Subject number: 22591136, 2010–2013, Study on early intervention of child obesity with a focus on adiposity rebound, Subject number: 25461559, 2013–2016, Exploratory/systematic cohort study to clarify the relationship between weight increase in childhood and obesity/metabolic disorder).

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 30, Issue 4, Pages 455–457, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2016-0227.

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