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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

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2191-0251
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Volume 31, Issue 1

Issues

Identifying depressive symptoms among diabetes type and the impact on hemoglobin A1c

Bethany A. Glick
  • Corresponding author
  • Nationwide Children’s Hospital, Pediatric Endocrinology, 700 Children’s Drive, Columbus, OH, USA
  • Email
  • Other articles by this author:
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/ K. Ming Chan Hong
  • Nationwide Children’s Hospital, Pediatric Endocrinology, 700 Children’s Drive, Columbus, OH, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kathryn Obrynba
  • Nationwide Children’s Hospital, Pediatric Endocrinology, 700 Children’s Drive, Columbus, OH, USA
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  • De Gruyter OnlineGoogle Scholar
/ Manmohan K. Kamboj
  • Nationwide Children’s Hospital, Pediatric Endocrinology, 700 Children’s Drive, Columbus, OH, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Robert P. Hoffman
  • Nationwide Children’s Hospital, Pediatric Endocrinology, 700 Children’s Drive, Columbus, OH, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-01-05 | DOI: https://doi.org/10.1515/jpem-2017-0241

Abstract

Background:

This study was designed to determine the effects of diabetes type and gender on depression risk determined by a highly sensitive screening questionnaire in adolescents. Glycemic control and counseling affect were also studied.

Methods:

A retrospective chart review of patients seen between 2013 and 2015 was performed. Five hundred and thirty adolescents with type 1 (T1DM) or 2 (T2DM) diabetes mellitus completed the Patient Health Questionnaire-9 (PHQ-9) to identify depressive symptoms. Hemoglobin A1c (HbA1c) was measured when the PHQ-9 was given, and at 1 year. Patients with increased depression risk were referred for counseling and comparisons were made between those who did and did not attend.

Results:

Females with T2DM, but not males, had increased depression compared to T1DM. Females had increased depression compared to males in T1DM (p = 0.046) and a near significant increase in T2DM (p = 0.069). In T1DM, but not T2DM, HbA1c levels were increased in high and moderate, compared to low, risk depression risk groups (p = 0.007). Follow-up HbA1c was unchanged 1 year later and there were no differences between those involved in counseling and those who refused to attend. Sex and type of diabetes had no effect on response to counseling.

Conclusions:

These results demonstrate increased depression in adolescents with T2DM compared to T1DM and in females compared to controls. Glycemic control did not change in adolescents who reported moderate to severe symptoms of depression and received counseling intervention compared to adolescents who declined counseling.

Keywords: adolescents; depression; diabetes; hemoglobin A1c; social work

References

  • 1.

    Cameron FJ, Northam EA, Ambler GR, Daneman D. Routine psychological screening in youth with type 1 diabetes and their parents. A notion whose time has come? Diabetes Care 2007;30:2716–24.Google Scholar

  • 2.

    Helgeson VS, Siminerio L, Escobar O, Becker D. Predictors of metabolic control among adolescents with diabetes: a 4-year longitudinal study. J Pediatr Psychol 2009;34:254–70.PubMedWeb of ScienceGoogle Scholar

  • 3.

    Winkley K. The epidemiology of depression in diabetes. European Diabetes Nursing 2008;5:91–6.CrossrefGoogle Scholar

  • 4.

    Grey M, Whittemore R, Tamborlane W. Depression in type 1 diabetes in children: natural history and correlates. J Psychosom Res 2002;53:907–11.CrossrefPubMedGoogle Scholar

  • 5.

    Kanner S, Hamrin V, Grey M. Depression in adolescents with diabetes. J Child Adolesc Psychiatr Nurs 2003;16:15–24.PubMedCrossrefGoogle Scholar

  • 6.

    Stewart S, Rao U, Emslie G, Klein D, White P. Depressive symptoms predict hospitalizations for adolescents with type 1 diabetes mellitus. Pediatrics 2005;115:1315–9.PubMedCrossrefGoogle Scholar

  • 7.

    Hains AA, Berlin KS, Davies WH, Parton EA, Alemzadeh R. Attributions of adolescents with type 1 diabetes in social situations: relationship with expected adherence, diabetes stress, and metabolic control. Diabetes Care 2006;29:818–22.CrossrefPubMedGoogle Scholar

  • 8.

    Corathers SD, Kichler J, Jones N-H, Houchen A, Jolly M, et al. Improving depression screening for adolescents with type 1 diabetes. Pediatrics 2013;132:e1395–402.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 9.

    Northam EA, Lin A, Finch S, Werther GA, Cameron FJ. Psychosocial well-being and functional outcomes in youth with type 1 diabetes 12 years after disease onset. Diabetes Care 2010;33:1430–7.Web of ScienceCrossrefPubMedGoogle Scholar

  • 10.

    Smaldone A, Honig J, Arons R, Weinger K. Comorbid hospitalizations for children with single and recurrent ketoacidosis. Diabetes Care 2005;53:A425.Google Scholar

  • 11.

    McGrady ME, Laffel L, Drotar D, Repaske D, Hood KK. Depressive symptoms and glycemic control in adolescents with type 1 diabetes: mediational role of blood glucose monitoring. Diabetes Care 2009;32:804–6.Web of ScienceCrossrefPubMedGoogle Scholar

  • 12.

    Bernstein CM, Stockwell MS, Gallagher MP, Rosenthal SL, Soren K. Mental health issues in adolescents and young adults with type 1 diabetes: prevalence and impact on glycemic control. Clin Pediatr 2013;52:10–5.Web of ScienceCrossrefGoogle Scholar

  • 13.

    Markowitz SM, Gonzalez JS, Wilkinson JL, Safren SA. A review of treating depression in diabetes: emerging findings. Psychosomatics 2011;52:1–18.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 14.

    Delamater AM. Psychological care of children and adolescents with diabetes. Pediatric Diabetes 2009;10:175–84.CrossrefPubMedWeb of ScienceGoogle Scholar

  • 15.

    Silverstein JH, Klingensmith G, Copeland K, Plotnick L, Kaufman F, et al. Care for children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care 2005;28:186–212.PubMedCrossrefGoogle Scholar

  • 16.

    Lustman PJ, Clouse RE. Depression in diabetic patients: the relationship between mood and glycemic control. J Diabetes Complications 2005;19:113–22.PubMedGoogle Scholar

  • 17.

    Hood KK, Beavers DP, Yi-Frazier J, Bell R, Dabelea D, et al. Psychosocial burden and glycemic control during the first six years of diabetes: results from the SEARCH for diabetes in youth study. J Adolesc Health 1014;55:498–504.Google Scholar

  • 18.

    Korbel CD, Wiebe DJ, Berg CA, Palmer DL. Gender difference in adherence to type 1 diabetes management across adolescence: the mediating role of depression. Children’s Healthcare 2007;36:83–93.CrossrefGoogle Scholar

  • 19.

    Cullum K, Howland LC, Instone S. Depressive symptoms and social support in adolescents with type 2 diabetes. J Pediatr Health Care 2015;30:57–64.PubMedWeb of ScienceGoogle Scholar

  • 20.

    Helgeson VS, Snyder PR, Escobar O, Siminerio L, Becker D. Comparison of adolescents with and without diabetes on indices of psychosocial functioning for three years. J Pediatr Psychol 2007;32:794–806.PubMedCrossrefGoogle Scholar

  • 21.

    La Greca AM, Swales T, Klemp S, Madigan S, Skyler J. Adolescents with diabetes: gender differences in psychosocial functioning and glycemic control. Children’s Health Care 1995;24:61–78.CrossrefGoogle Scholar

  • 22.

    Inoue T, Tanaka T, Nakagawa S, Nakato Y, Kamyeyama R, et al. Utility and limitations of PHQ-9 in a clinic specializing in psychiatric care. BMC Psychiatry 2012;12:23.Web of ScienceGoogle Scholar

  • 23.

    Gilbody S, Richards D, Brealey S, Hewitt C. Screening for depression in medical settings with the patient health questionnaire (PHQ): a diagnostic meta-analysis. J Gen Intern Med 2007;22:1596–602.PubMedWeb of ScienceCrossrefGoogle Scholar

  • 24.

    Kroenke K, Spitzer RL, Williams JB. The PHQ-9. J Gen Intern Med 2001;16:606–13.CrossrefPubMedGoogle Scholar

  • 25.

    Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes. A meta-analysis. Diabetes Care 2001;24:1069–78.PubMedCrossrefGoogle Scholar

  • 26.

    Pinhas-Hamiel O, Zeitler P. “Who is the wise man? – The one who foresees consequences:” childhood obesity, new associated comorbidity and prevention. Prev Med 2000;31:702–5.PubMedCrossrefGoogle Scholar

  • 27.

    Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004;27:813–23.PubMedCrossrefGoogle Scholar

  • 28.

    Nicole Vogelzangs MS, Beekman AT, Newman AB, Satterfield S, Simonsick EM, et al. Depressive symptoms and change in abdominal obesity in older persons. Arch Gen Psychiatry 2008;65:1386–93.CrossrefWeb of SciencePubMedGoogle Scholar

  • 29.

    Bonnet F, Irving K, Terra J-L, Nony P, Berthezene F, et al. Anxiety and depression are associated with unhealthy lifestyle in patients at risk of cardiovascular disease. Atherosclerosis 2005;178:339–44.PubMedCrossrefGoogle Scholar

  • 30.

    Nabkasorn C, Miyai N, Sootmongkol A, Junprasert S, Yamamoto H, et al. Effects of physical exercise on depression, neuroendocrine stress hormones and physiological fitness in adolescent females with depressive symptoms. Eur J Public Health 2006;16:179–84.PubMedCrossrefGoogle Scholar

  • 31.

    Polonsky WH, Fisher L, Earles J, Dudl JR, Lees J, et al. Assessing psychosocial distress in diabetes: development of the diabetes distress scale. Diabetes Care 2005;28:626–31.CrossrefPubMedGoogle Scholar

  • 32.

    Weissberg-Benchell J, Antisdel-Lomaglio J. Diabetes-specific emotional distress among adolescents: feasibility, reliability, and validity of the problem areas in diabetes-teen version. Pediatr Diabetes 2011;12:341–4.PubMedCrossrefWeb of ScienceGoogle Scholar

About the article

Corresponding author: Bethany A. Glick, MSSA, LISW-S, Nationwide Children’s Hospital, Pediatric Endocrinology, 700 Children’s Drive,Columbus, OH 43205, USA, Phone: +614-722-4425, Fax: +614-722-4440


Received: 2017-06-19

Accepted: 2017-11-10

Published Online: 2018-01-05

Published in Print: 2018-01-26


Author contributions: The authors declare no relevant conflict of interest. The authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 31, Issue 1, Pages 39–44, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2017-0241.

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