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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

Online
ISSN
2191-0251
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Volume 31, Issue 5

Issues

Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents

Jong Seo Yoon
  • Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Yeongtong-gu, Suwon, Republic of Korea
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/ Cheol Hwan So
  • Department of Pediatrics, Wonkwang University School of Medicine, Wonkwang University Hospital, Iksan, Jeonbuk, Republic of Korea
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/ Hae Sang Lee
  • Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Yeongtong-gu, Suwon, Republic of Korea
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/ Jin Soon Hwang
  • Corresponding author
  • Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon 443-721, Republic of Korea, Phone: +82-31-219-5166, Fax: +82-31-219-5169
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Published Online: 2018-04-13 | DOI: https://doi.org/10.1515/jpem-2017-0463

Abstract

Background:

The diagnostic cutoff points for indicators of type 2 diabetes mellitus (T2DM) in the pediatric population have not been defined thus far.

Methods:

A retrospective, single-center study was conducted from April 2003 to May 2016. We enrolled 236 overweight or obese children and adolescents aged 4–17 years. Thirty-nine (26.9%) of 145 patients had T2DM according to the oral glucose tolerance test results.

Results:

A glycated hemoglobin (HbA1c) level of 6.5% had a sensitivity and specificity of 87.2% and 98.5%, respectively, for detecting T2DM. The optimal HbA1c cutoff level for T2DM was >6.2% (94.7% sensitivity, 95.5% specificity).

Conclusions:

We observed that the use of an HbA1c level of 6.5% had a lower sensitivity for detecting T2DM than an HbA1c level of >6.2%.

Keywords: HbA1c; obesity; pediatrics; screening; type 2 diabetes

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About the article

Received: 2017-11-06

Accepted: 2018-03-05

Published Online: 2018-04-13

Published in Print: 2018-05-24


Author contributions: J.S. Yoon conceptualized and designed the study, enrolled the subjects, carried out the initial analysis and drafted the initial manuscript; C.H. So conceptualized and designed the study, carried out the initial statistical analysis and reviewed and revised the manuscript; H.S. Lee conceptualized and designed the study, coordinated and supervised data collection and critically reviewed the manuscript; J.S. Hwang made a substantial contribution to the concept and design, acquisition of data, analysis and interpretation of data and reviewed and critically revised important intellectual content. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 31, Issue 5, Pages 503–506, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2017-0463.

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