August GP, Lippe BM, Blethen SL, Rosenfeld RG, Seelig SA, et al. Growth hormone treatment in the United States: demographic and diagnostic features of 2331 children. J Pediatr 1990;116:899–903.CrossrefPubMedGoogle Scholar
Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, et al. Diagnosis and treatment of primary adrenal insufficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2016;101:364–89.CrossrefPubMedWeb of ScienceGoogle Scholar
McDonough RJ, Alba P, Dileepan K, Cernich JT. Employing a results-based algorithm to reduce laboratory utilization in ACTH stimulation testing. J Pediatr Endocrinol Metab 2018;31:429–33.CrossrefPubMedWeb of ScienceGoogle Scholar
Weintrob N, Sprecher E, Josefsberg Z, Weininger C, Aurbach-Klipper Y, et al. Standard and low-dose short adrenocorticotropin test compared with insulin-induced hypoglycemia for assessment of the hypothalamic-pituitary-adrenal axis in children with idiopathic multiple pituitary hormone deficiencies. J Clin Endocrinol Metab 1998;83:88–92.CrossrefPubMedGoogle Scholar
Abdu TA, Elhadd TA, Neary R, Clayton RN. Comparison of the low dose short Synacthen test (1 microg), the conventional dose short Synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease. J Clin Endocrinol Metab 1999;84:838–43.PubMedGoogle Scholar
Gonzálbez J, Villabona C, Ramón J, Navarro MA, Giménez O, et al. Establishment of reference values for standard dose short Synacthen test (250 microgram), low dose short Synacthen test (1 microgram) and insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in normal subjects. Clin Endocrinol (Oxf) 2000;53:199–204.CrossrefPubMedGoogle Scholar
Feldman EC, Stabenfeldt GH, Farver TB, Addiego LA. Comparison of aqueous porcine ACTH with synthetic ACTH in adrenal stimulation tests of the female dog. Am J Vet Res 1982;43:522–4.PubMedGoogle Scholar
Maghnie M, Uga E, Temporini F, Di Iorgi N, Secco A, et al. Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests. Eur J Endocrinol 2005;152:735–41.CrossrefPubMedGoogle Scholar
Streeten DH, Anderson GH Jr, Bonaventura MM. The potential for serious consequences from misinterpreting normal responses to the rapid adrenocorticotropin test. J Clin Endocrinol Metab 1996;81:285–90.PubMedGoogle Scholar
Ng SM, Agwu JC, Dwan K. A systematic review and meta-analysis of Synacthen tests for assessing hypothalamic-pituitary-adrenal insufficiency in children. Arch Dis Child 2016;101:847–53.CrossrefPubMedWeb of ScienceGoogle Scholar
Ospina NS, Al Nofal A, Bancos I, Javed A, Benkhadra K, et al. ACTH stimulation tests for the diagnosis of adrenal insufficiency: systematic review and meta-analysis. J Clin Endocrinol Metab 2016;101:427–34.Web of ScienceCrossrefGoogle Scholar
Hurel SJ, Thompson CJ, Watson MJ, Harries PH, Baylis PH, et al. The short Synacthen and insulin stress tests in the assessment of the hypothalamic-pituitary-adrenal axis. Clin Endocrinol 1996;44:141–6.CrossrefGoogle Scholar
Jayakumari C, George GS, Nair A, Jabbar PK, Jessy SJ, et al. ACTH stimulation test with long acting ACTH preparation for the diagnosis of adrenal insufficiency. Abstract presented in the National conference of Endocrine Society of India ESICON 2017. Ind J Endocrin Met 2017;21:S62.Google Scholar
Kelestimur F, Akgün A, Günay O. A comparison between short Synacthen test and depot Synacthen test in the evaluation of cortisol reserve of adrenal gland in normal subjects. J Endocrinol Invest 1995;18:823–6.CrossrefPubMedGoogle Scholar
O’Grady MJ, Hensey C, Fallon M, Hoey H, Murphy N, et al. Requirement for age-specific peak cortisol responses to insulin-induced hypoglycaemia in children. Eur J Endocrinol 2013;169:139–45.CrossrefPubMedWeb of ScienceGoogle Scholar
Lindholm J, Kehlet H. Re-evaluation of the clinical value of the 30 min ACTH test in assessing the hypothalamic- pituitary-adrenocortical function. Clin Endocrinol (Oxf) 1987;26:53–9.PubMedCrossrefGoogle Scholar
Ach T, Yosra H, Jihen M, Abdelkarim Asma B, Maha K, et al. Cortisol cut-points for the glucagon stimulation test in the evaluation of hypothalamic pituitary adrenal axis. Endocr J 2018;65:935–42.PubMedCrossrefGoogle Scholar
About the article
Published Online: 2018-12-07
Published in Print: 2019-01-28
Author contributions: RS conceived the study, participated in the coordination of the study, carried out the statistical analysis and drafted the manuscript. SM, VM, KR and BJ participated in the study design and collected the data. VJ participated in the coordination of the study, chart review and drafting of the manuscript. All the authors read and approved the final manuscript.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.