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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Fei Hong / Mericq, Veronica / Toppari, Jorma


IMPACT FACTOR 2018: 1.239

CiteScore 2018: 1.22

SCImago Journal Rank (SJR) 2018: 0.507
Source Normalized Impact per Paper (SNIP) 2018: 0.562

Online
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2191-0251
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Volume 32, Issue 1

Issues

Adiponectin, leptin and high sensitivity C-reactive protein values in obese children – important markers for metabolic syndrome?

Ramona F. Stroescu
  • Corresponding author
  • Louis Țurcanu Emergency Hospital for Children, Timișoara, Romania
  • Victor Babes University of Medicine and Pharmacy, Timișoara, Romania
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Otilia Mărginean
  • Louis Țurcanu Emergency Hospital for Children, Timișoara, Romania
  • Victor Babes University of Medicine and Pharmacy, Timișoara, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Teofana Bizerea
  • Louis Țurcanu Emergency Hospital for Children, Timișoara, Romania
  • Victor Babes University of Medicine and Pharmacy, Timișoara, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mihai Gafencu
  • Louis Țurcanu Emergency Hospital for Children, Timișoara, Romania
  • Victor Babes University of Medicine and Pharmacy, Timișoara, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Adrian Voicu / Gabriela Doroș
  • Louis Țurcanu Emergency Hospital for Children, Timișoara, Romania
  • Victor Babes University of Medicine and Pharmacy, Timișoara, Romania
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2018-12-08 | DOI: https://doi.org/10.1515/jpem-2018-0378

Abstract

Background

Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C-reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity such as leptin, adiponectin and high sensitivity C-reactive protein (hs-CRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome (MetS) in pediatric population.

Methods

A cross-sectional study was conducted over a period of 1 year, between July 2013 and June 2014, on 122 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timişoara, in the departments of Diabetes and Nutritional Diseases, Endocrinology and Cardiology. The patients were divided into two groups, according to the presence of MetS.

Results

MetS was present in 27% of obese children. The groups were homogenous with respect to age, sex and body mass index (BMI). Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively).

Conclusions

hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in pediatric population.

Keywords: adiponectin; high sensitivity C-reactive protein; leptin; pediatric population

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About the article

Corresponding author: Ramona F. Stroescu, MD, PhD, Louis Țurcanu Emergency Hospital for Children, Iosif Nemoianu 300011, Timișoara, Romania; and Victor Babes University of Medicine and Pharmacy, Timișoara, Romania


Received: 2018-08-30

Accepted: 2018-11-11

Published Online: 2018-12-08

Published in Print: 2019-01-28


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: This research was supported by a grant at University of Medicine and Pharmacy “Victor Babes” Timisoara PII-C2-TC-2014 ChildObesity-2014 which was obtained by Ramona Stroescu.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Journal of Pediatric Endocrinology and Metabolism, Volume 32, Issue 1, Pages 27–31, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: https://doi.org/10.1515/jpem-2018-0378.

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